Medical Sciences

Faculty of the Committee on Higher Degrees in Medical Sciences

Biological and Biomedical Sciences (BBS)

Graduate Courses of Reading and Research

*BBS 380. Reading and Research in Biological and Biomedical Sciences
Catalog Number: 0349
David L. Van Vactor (Medical School) 2089

Biological Chemistry and Molecular Pharmacology

Primarily for Graduates

BCMP 201. Proteins: Structure, Function and Catalysis
Catalog Number: 5068
James J. Chou (Medical School), Stephen C. Blacklow (Medical School), Michael J. Eck (Medical School), Frederick P. Roth (Medical School), William Shih (Medical School), and Michael S. Wolfe (Medical School)
Half course (spring term). Tu., Th., 9–10:30, W., 4:30–6.
Protein biochemistry with emphasis on the interrelated roles of protein structure, catalytic activity, and macromolecular interactions in biological processes. Both fundamental principles and experimental methods will be covered.
Note: The course is intended for all Division of Medical Sciences (DMS) graduate students and is open to advanced undergraduates. Offered jointly with the Medical School as BP 714.0.

BCMP 207. Molecular Approaches to Drug Action, Discovery, and Design
Catalog Number: 0529 Enrollment: May be limited.
Donald M. Coen (Medical School), and associates.
Half course (spring term). Tu., Th., 3:30–5:30.
Application of molecular and structural biology, genetics, genomics, chemistry, and modern enzymology to drug action and development of new therapies. Analyzes molecular underpinnings of pharmacological principles. Examples drawn from diseases including cancer and AIDS.
Note: Offered jointly with the Medical School as BP 715.0. Primarily for graduate students.

[BCMP 210. Theory and Practice of Techniques in Molecular Biology ]
Catalog Number: 1230
Welcome W. Bender (Medical School) and Stanley Tabor (Medical School)
Half course (fall term). M., W., F., 2–4.
Reviews principles of common lab techniques, discusses recent innovations. Topics: synthesis, separation and detection of nucleic acids and proteins, with traditional or high-throughput methods. Lectures, lab experiments, discussions, occasional field trips to core facilities.
Note: Expected to be given in 2010–11. Offered jointly with the Medical School as BP 725.0.
Prerequisite: Prior exposure to molecular techniques and current residence in a lab equipped for molecular work.

[*BCMP 213. Behavioral Pharmacology]
Catalog Number: 4782 Enrollment: Limited to 15.
Jack Bergman (Medical School) and Carol A. Paronis (Medical School)
Half course (spring term). Tu., Th., 3–4:30.
Introduction to CNS pharmacology and behavior in seminar format. Effects of psychomotor stimulants, antischizophrenics, opioid analgesics, and antianxiety agents on behavior. Emphasis on methodology and pharmacological analysis; attention to tolerance, drug dependence/addiction.
Note: Expected to be given in 2010–11. Offered jointly with the Medical School as BP 719.0.

*BCMP 218. Molecular Medicine
Catalog Number: 2049 Enrollment: Limited to 35.
Irving M. London (Medical School), David E. Cohen (Medical School), and George Q. Daley (Medical School)
Half course (fall term). Tu., 1–3.
The course involves close reading of primary scientific papers that illustrate classical paradigms in molecular medicine. Emphasis will be placed on papers that demonstrate the connections between defined molecular and genetic abnormalities and disease pathogenesis.
Note: Faculty mentors will guide student-led discussions of the papers. Jointly offered with the Medical School as HT 140.
Prerequisite: Molecular Biology and Biochemistry.

[BCMP 228. Macromolecular NMR]
Catalog Number: 3969
Gerhard Wagner (Medical School) and James J. Chou (Medical School)
Half course (fall term). M., F., 2–3:30.
Theory and practice of modern methods of macromolecular structure determination using multi-dimensional NMR.
Note: Expected to be given in 2010–11. Given in alternate years. Offered jointly with the Medical School as BP 722.0. Classroom lectures on Mondays and Fridays. Wednesdays are reserved for either classroom lectures or practical training and hands-on problem solving. The latter includes basic aspects of spectrometer operation, computer-based assignment of protein NMR spectra and structure calculation. Wednesday slots are reserved for registered students and are open ended for completing the training tasks.

BCMP 230. Principles and Practice of Drug Development
Catalog Number: 1295
Stan Neil Finkelstein (Medical School) and Robert H. Rubin (Medical School)
Half course (fall term). Th., 3–6.
Critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules. Economic considerations of the drug development process.

BCMP 234. Cellular Metabolism and Human Disease
Catalog Number: 9644
Thomas Michel (Medical School), Robert A. Lue and members of the Departments
Half course (spring term). M., W., F., 9–10:30.
Cellular and organismal metabolism, with focus on interrelationships between key metabolic pathways and human disease states. Genetic and acquired metabolic diseases and functional consequences for specific organ systems. Lectures, conferences are integrated with clinical encounters.
Note: Also listed as MCB 234. Lectures for this class are transmitted live to and from electronic classrooms located at HMS and in Cambridge; the inter-campus video link permits real-time interactions between students and faculty at each site. Small conference sections are held on both campuses; weekly clinical encounters take place only at the HMS classroom.
Prerequisite: Knowledge of introductory biochemistry, genetics, and cell biology required (MCB 52 and 54 or equivalent); one year of organic chemistry.

BCMP 235. Principles of Human Disease: Physiology and Pharmacology
Catalog Number: 3769
David E. Golan (Medical School), Julian L. Seifter (Medical School), and Alain Viel
Half course (fall term). M., W., F., 9–10:30.
Principles of human physiology, pathophysiology, and drug action-including mechanisms of organ function in health and disease, and strategies for designing drug-based therapeutic interventions-discussed in lectures, critical readings, clinical case scenarios, and patient presentations.
Note: Students may attend lectures in either Cambridge or Boston as lectures will be transmitted live from HMS to Cambridge and vice versa; the inter-campus link permits real-time interactions among students and faculty at both sites.
Prerequisite: Knowledge of introductory biochemistry, molecular biology, and cell biology required (MCB52 and MCB54 or equivalent); one year of organic chemistry.

Graduate Courses of Reading and Research

[*BCMP 301. High Throughput Functional Proteomics]
Catalog Number: 1535
Edward E. Harlow (Medical School) 2863
Note: Expected to be given in 2010–11.

[*BCMP 308. Blood Coagulation and Vascular Biology]
Catalog Number: 3950
Bruce Furie (Medical School) 3937
Note: Expected to be given in 2010–11.

*BCMP 309. Regulation of Membrane Protein and Lipid Dynamics: Molecular Mechanisms and Biological Implications
Catalog Number: 1558
David E. Golan (Medical School) 1558

*BCMP 310. Molecular and Cellular Mechanisms of Insulin Action
Catalog Number: 4299
Morris F. White (Medical School) 3158

*BCMP 311. Structure of Viruses, Viral Proteins, Receptors, Transcription Factors
Catalog Number: 3623
Stephen C. Harrison (Medical School) 3597

*BCMP 312. Downregulating DNA Repair: Phosphatases & MicroRNAs - (New Course)
Catalog Number: 30165
Dipanjan Chowdhury 6266

*BCMP 314. Protein NMR Spectroscopy of Membrane Protein
Catalog Number: 3449
James J. Chou (Medical School) 4950

*BCMP 315. Growth Factor Structure and Biological Activity
Catalog Number: 6034
Michael Klagsbrun (Medical School) 3167

*BCMP 316. Signal Transduction and Phosphorylation in Heart Disease - (New Course)
Catalog Number: 96794
Maria Irene Kontaridis 6398

*BCMP 317. Structural and Cellular Biology of Insulin Signal Transduction, Insulin, Resistance, Diabetes and Obesity
Catalog Number: 3354
Steven E. Shoelson (Medical School) 3951

*BCMP 318. Innate Immunity Against RNA Viruses - (New Course)
Catalog Number: 45272
Sun Hur 6403

*BCMP 319. Histone Variants and Chromosome Biology
Catalog Number: 1748
Kami Ahmad (Medical School) 4592

*BCMP 320. Systems and Synthetic Biology
Catalog Number: 0265
Pamela A. Silver (Medical School) 1595

*BCMP 322. Thyroid Hormone Metabolism and Action
Catalog Number: 2050
Antonio C. Bianco (Medical School) 5387

*BCMP 324. Structure and Replication of DNA
Catalog Number: 5059
Charles C. Richardson (Medical School) 2479

*BCMP 325. Genomic Instability and Cancer Susceptibility
Catalog Number: 4110
Alan D. D’Andrea (Medical School) 3532

*BCMP 328. Computational Analysis of Sequence Variation and Divergence
Catalog Number: 2468
Shamil R. Sunyaev (Medical School) 4671

*BCMP 329. Structure Biology of Cytoplasmic Signal Transduction
Catalog Number: 5005
Michael J. Eck (Medical School) 1739

*BCMP 331. Graduate Research on the Molecular Basis of Neurodegenerative Diseases
Catalog Number: 9727
Michael S. Wolfe (Medical School) 4543

*BCMP 332. Structural Neurology
Catalog Number: 0276
Peter T. Lansbury (Medical School) 2115

*BCMP 335. Biochemical and Genetic Analysis of Eukaryotic Gene Expression
Catalog Number: 8052
Stephen Buratowski (Medical School) 1790

*BCMP 337. Drosophila Molecular Genetics
Catalog Number: 0782
Welcome W. Bender (Medical School) 7083

*BCMP 338. Eukaryotic Gene Regulation
Catalog Number: 0549
Kevin Struhl (Medical School) 7415

*BCMP 339. Regulation of the Cellular Uptake of Macromolecular Nutrients
Catalog Number: 3453
Marianne Wessling-Resnick (Public Health) 1315

*BCMP 340. Biologically Active Small Molecules
Catalog Number: 8300
Jon Clardy (Medical School) 4667

*BCMP 343. Molecular Genetics of Herpes Viruses
Catalog Number: 0868
Donald M. Coen (Medical School) 7617

*BCMP 344. Molecular Pharmacology of Excitable Membranes
Catalog Number: 0200
Gary R. Strichartz (Medical School) 7530

*BCMP 345. Transcription Factors in Hematopoiesis and Leukemogenesis
Catalog Number: 4792
Alan B. Cantor (Medical School) 5150

*BCMP 348. Chromatin and Cancer
Catalog Number: 6409
Charles M. Roberts (Medical School) 5151

*BCMP 349. Targeting Deregulated Apoptotic and Transcriptional Pathways in Cancer
Catalog Number: 1071
Loren D. Walensky (Medical School) 5665

*BCMP 350. Signaling Pathways in Pancreatic Cancer
Catalog Number: 1254
Nabeel El-Bardeesy (Medical School) 6164

*BCMP 352. Chemical Mediators in Inflammation and Resolution
Catalog Number: 4853
Charles N. Serhan (Medical School) 3163

*BCMP 353. Epigenomics and Chromatin Systems Biology
Catalog Number: 8682
Yujiang Shi (Medical School) 5509

*BCMP 354. DNA Replication, Searching Mechanisms of DNA-Binding Factors
Catalog Number: 6823
Antoine van Oijen (Medical School) 5084

*BCMP 355. Transcriptional Control of Hematopoiesis and Leukemia
Catalog Number: 4489
Hanno Reinhard Hock (Medical School) 5660

*BCMP 356. NMR Spectroscopy of Proteins and Metabolites
Catalog Number: 8093
Gerhard Wagner (Medical School) 2626

*BCMP 358. Targeting Apoptosis Regulation in Cancer
Catalog Number: 6735
Anthony G. Letai (Medical School) 5663

*BCMP 359. Molecular Mechanisms of Signal Transduction
Catalog Number: 8520
Elaine A. Elion (Medical School) 2941

*BCMP 360. Regulating Skeletal Myogenesis
Catalog Number: 6934
Andrew B. Lassar (Medical School) 2946

*BCMP 361. X-Ray Crystallographic Studies of Viruses and Proteins
Catalog Number: 4155
James M. Hogle (Medical School) 2943

*BCMP 362. Eukaryotic Survival Decisions
Catalog Number: 4972
David E. Fisher (Medical School) 1800

*BCMP 363. The Mechanics and Regulation of Mitosis
Catalog Number: 4981
David Pellman (Medical School) 3702

*BCMP 366. Stem Cells in Disease and Development
Catalog Number: 9236
George Q. Daley (Medical School) 4951

*BCMP 370. Advanced Topics in Biological Chemistry and Molecular Pharmacology
Catalog Number: 0482
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (7 weeks). Two seminars, which can be taken in different terms, are required for credit.
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*BCMP 371. Initiation of Eukaryotic DNA Replication: A Biochemical Analysis
Catalog Number: 3739
Johannes Walter (Medical School) 3846

*BCMP 372. Methods and Applications in Computational Molecular Biology
Catalog Number: 1638
Frederick P. Roth (Medical School) 3912

[*BCMP 373. Blood Coagulation and Vascular Biology]
Catalog Number: 5747
Barbara C. Furie (Medical School) 3936
Note: Expected to be given in 2010–11.

*BCMP 374. Growth Factors and Signal Transduction
Catalog Number: 1179
Michael R. Freeman (Medical School) 5169

*BCMP 375. Biomolecular Nanotechnology
Catalog Number: 3288
William Shih (Medical School) 5256

*BCMP 376. Mechanisms of Action of Antibiotics
Catalog Number: 3033
Daniel E. Kahne 5065

*BCMP 377. Quantitative Proteomics of Cancer Progression
Catalog Number: 5225
Jarrod Marto (Medical School) 5326

*BCMP 378. Mechanisms of Hepatic Cholesterol Elimination
Catalog Number: 6669
David E. Cohen (Medical School) 3478

*BCMP 379. Biochemical and Molecular Regulation of Vascular Growth
Catalog Number: 9374
Marsha Moses (Medical School) 5388

*BCMP 380. Chemical Approaches to Cell Division
Catalog Number: 0726
Ulrike Sophie Eggert (Medical School) 5729

*BCMP 381. Functional Small Molecules for Biological Discovery
Catalog Number: 8841
Nathanael Gray (Medical School) 5730

*BCMP 382. Mechanisms of RNAi in Stem Cells
Catalog Number: 9601
Richard Ian Gregory (Medical School) 5743

*BCMP 383. Integrated and Functional Genomic Studies of Human Cancer
Catalog Number: 5334
Levi Alexander Garraway (Medical School) 6203

*BCMP 384. Embryonic stem cells, Nuclear Transfer, Cancer, Reprogramming
Catalog Number: 5330
Konrad Hochedlinger 6101

Cell Biology

Primarily for Graduates

Cell Biology 207. Developmental Biology: Molecular Mechanisms of Vertebrate Development
Catalog Number: 2044 Enrollment: Limited to 25.
Andrew B. Lassar (Medical School), Patricia A. D’Amore (Medical School), Alan J. Davidson (Medical School), John G. Flanagan (Medical School), Xi He (Medical School), Jordan A. Kreidberg (Medical School), Richard L. Maas (Medical School), Clifford J. Tabin (Medical School), and Malcolm Whitman (Medical School)
Half course (spring term). W., F., 2–4.
Analyzes the developmental programs of frog, chick, zebrafish, and mouse embryos, emphasizing experimental strategies for understanding the responsible molecular mechanisms that pattern the vertebrate embryo.
Note: Offered jointly with the Medical School as CB 710.0. Includes lectures and conference sessions in which original literature is discussed in depth. Short research proposals are required in lieu of exams.

Cell Biology 211 (formerly Cell Biology 211a). Molecular and Systems Level Cancer Cell Biology
Catalog Number: 5771
Piotr Sicinski (Medical School), Jarrod Marto (Medical School), and Marc Vidal (Medical School)
Half course (spring term). M., W., 12–1:30.
Examines the molecular and systems basis of cancer including alterations in signal transduction, cell cycle, apoptosis and DNA repair.
Note: Alternate years with Cell Biology 212. Offered jointly with the Medical School as CB 704.0.
Prerequisite: General knowledge of biochemistry, molecular genetics, and cell biology.

[Cell Biology 212 (formerly Cell Biology 211b). Molecular Mechanisms of Cancer]
Catalog Number: 4169
James A. DeCaprio (Medical School) and Myles A. Brown (Medical School)
Half course (fall term). M., W., 12–1:30.
Examines the molecular basis of human cancer, including lung, breast, prostate, melanoma and leukemia. Concepts including stem cells, senescence, genomic instability, angiogenesis, oncogenes, tumor suppressors and viruses in human cancer will be examined.
Note: Expected to be given in 2010–11. Alternate years with Cell Biology 211.
Prerequisite: Advanced biochemistry, molecular genetics, and cell biology.

[Cell Biology 214. Developmental Biology and Genetics]
Catalog Number: 3458 Enrollment: Limited to 14.
David L. Van Vactor (Medical School), Spyros Artavanis-Tsakonas (Medical School), and Jarema Malicki (Medical School)
Half course (fall term). W., 4–6, Th., 4:30–6:30.
The course will explore genetic tools for the analysis of developmental phenomena in flies, worms, and mice. We cover a continuum from pattern formation, cell growth, and cell fate to cell differentiation and morphogenesis.
Note: Expected to be given in 2010–11. Offered jointly with the Medical School as CB 720.0. Contact course director at 617-432-2195 with questions.
Prerequisite: General genetics and developmental biology courses recommended.

[Cell Biology 225. Hormonally Active Pollutants] - (New Course)
Catalog Number: 94802
Joan V. Ruderman (Medical School)
Half course (spring term). Th., 4:30–6:30.
A surprising number of environmental pollutants can mimic or interfere with developmental and physiological effects of steroid hormones. This course examines landmark discoveries and covers current work in this emerging area.
Note: Expected to be given in 2010–11. The first half of this course can be taken independently as a quarter course, Cell Biology 300a. Hormonally Active Pollutants.
Prerequisite: Open to all graduate and medical students, and to advanced undergraduates.

Cell Biology 226. Concepts in Development, Self-Renewal, and Repair
Catalog Number: 8747 Enrollment: Limited to 14.
Laurel A. Raftery (Medical School), Alan J. Davidson (Medical School), Iain A. Drummond (Medical School), Niels Geijsen (Medical School), N. Nanda Nanthakumar (Medical School), Lizabeth A. Perkins (Medical School), and David T. Scadden
Half course (fall term). F., 2–5.
Explores developmental mechanisms through the life cycle, contrasting pluripotency and cell fate restriction in embryos and adult tissues. In depth analysis of in vivo approaches, with emphasis on adult stem cells, tissue repair and self-renewal.
Note: Offered jointly with the Medical School as CB 721.0. For more information visit: www.mgh.harvard.edu/bbs/index.htm
Prerequisite: Upper division cell biology or equivalent.

Graduate Courses of Reading and Research

*Cell Biology 304. Regulation of the Cell Cycle
Catalog Number: 0414
Joan V. Ruderman (Medical School) 2622

*Cell Biology 305. Bone Cells Differentiation, Function and Signaling - (New Course)
Catalog Number: 60379
Roland Elie Baron 6397

*Cell Biology 306. Sirtuins, DNA Repair and Metabolic Homeostasis - (New Course)
Catalog Number: 75486
Raul Mostoslavsky 6402

*Cell Biology 307. Cell-Cell Signaling in Neural Development
Catalog Number: 1911
John G. Flanagan (Medical School) 3149

*Cell Biology 308. Membrane Biology
Catalog Number: 6173
Dennis A. Ausiello (Medical School) 1288

*Cell Biology 309. Coupled Interactions in Gene Expression Factories
Catalog Number: 2523
Robin Reed (Medical School) 2319

*Cell Biology 310. Mechanisms of Vertebrate Hedgehog Signaling
Catalog Number: 9189
Adrian Salic (Medical School) 5351

*Cell Biology 311. Cardiovascular Signal Transduction
Catalog Number: 9196
Thomas Michel (Medical School) 4392

*Cell Biology 312. Molecular Mechanisms of Transcriptional Control
Catalog Number: 8538
Anders Michael Naar (Medical School) 4328

*Cell Biology 313. Systems Biology of Mammalian Signal Transduction - (New Course)
Catalog Number: 23964
Peter K. Sorger (Medical School) 5544

*Cell Biology 314. Molecular Biology of Extracellular Matrix
Catalog Number: 5077
Bjørn R. Olsen (Dental School) 1164

[*Cell Biology 315. Biological Information Storage and Exchange]
Catalog Number: 9463
Michael Levin (Dental School) 4560
Note: Expected to be given in 2010–11.

*Cell Biology 316. Mechanism and Function of Intracellular Protein Turnover
Catalog Number: 1017
Alfred L. Goldberg (Medical School) 2827

*Cell Biology 317. Mechanisms of Programmed Cell Death
Catalog Number: 2270
Junying Yuan (Medical School) 2105

*Cell Biology 318. Molecular Biology of Cell Growth Regulation and Transformation
Catalog Number: 3355
John Blenis (Medical School) 2612

*Cell Biology 321. Neuronal Pathfinding and Synaptogenesis
Catalog Number: 4841
David L. Van Vactor (Medical School) 2089

*Cell Biology 323. Biology of Membranes and Intercellular Junctions
Catalog Number: 2651
Daniel A. Goodenough (Medical School) 4077

*Cell Biology 326. Signal Transduction During Early Development
Catalog Number: 1872
Malcolm Whitman (Medical School) 3267

*Cell Biology 328. Receptor-Mediated Endocytosis
Catalog Number: 0438
Tomas Kirchhausen (Medical School) 1155

*Cell Biology 329. The Ubiquitin-Proteasome Pathway
Catalog Number: 6826
Daniel Finley (Medical School) 2313

*Cell Biology 330. Experimental Approaches to Developmental Biology
Catalog Number: 6590 Enrollment: Limited to 16.
David L. Van Vactor (Medical School), Amy J. Wagers (Medical School) and members of the Division.
Half course (fall term; repeated spring term). M., through Sa., 9–9 p.m. over two week period in January.
Provides a rapid survey of major topics and themes in developmental biology in parallel with hands-on exposure to a variety of experimental approaches, technologies and model systems (Drosophilia, C. elegans, Xenopus, chick & mouse).
Note: Open to all first-year BBS students; permission of the instructor required for all others.

*Cell Biology 332. Mass Spectrometry and Proteomics
Catalog Number: 1568
Steven P. Gygi (Medical School) 3939

*Cell Biology 333. Electron Crystallographic Structure Determination of Leukotriene
Catalog Number: 9254
Thomas Walz (Medical School) 3778

*Cell Biology 335. Signal Transduction
Catalog Number: 2542
Lewis C. Cantley (Medical School) 1287

*Cell Biology 336. Signal Transduction in Normal and Transformed Cells
Catalog Number: 6833
Joan S. Brugge (Medical School) 1486

*Cell Biology 339. Cell Morphogenesis and Regulation
Catalog Number: 3898
Marc W. Kirschner (Medical School) 1078

*Cell Biology 340. Dissection of Angiogenic Signaling in Zebrafish
Catalog Number: 7792
Joanne Chan (Medical School) 5391

*Cell Biology 341. Centriole, Centrosome and Cilium: Biogenesis, Function and Evolution
Catalog Number: 5693
Tomer Avidor-Reiss (Medical School) 5352

*Cell Biology 342. Cytoskeleton in Development and Cancer
Catalog Number: 4059
Sheila Thomas (Medical School) 3777

*Cell Biology 343. Mechanisms of Mammalian Cell Differentiation and Gene Expression
Catalog Number: 0202
Bruce M. Spiegelman (Medical School) 7733

*Cell Biology 344. Molecular Mechanism of Signal Transduction
Catalog Number: 6093
Xi He (Medical School) 2004

*Cell Biology 345. Protein Transport Across the Endoplasmic Reticulum Membrane
Catalog Number: 6793
Tom Rapoport (Medical School) 1815

*Cell Biology 346. Belief Options for Practicing Scientists
Catalog Number: 1591
Andrius Kazlauskas (Medical School) 2088

*Cell Biology 347. Cellular and Molecular Aspects of Insulin Action
Catalog Number: 1494
C. Ronald Kahn (Medical School) 2019

*Cell Biology 349. Gene Silencing and Chromosome Structure
Catalog Number: 8765
Danesh Moazed (Medical School) 4254

*Cell Biology 351. Cardiovascular Stem Cells in Development and Disease
Catalog Number: 7604
Kenneth R. Chien (Medical School) 5667

*Cell Biology 353. Regulation of Epithelial Morphogenesis by TGF-beta Family Signaling
Catalog Number: 8239
Laurel A. Raftery (Medical School) 8686

*Cell Biology 354. Basic and Applied Mechanisms of Intracellular Transport
Catalog Number: 7605
Victor Wee Hsu (Medical School) 2606

*Cell Biology 356. Cell Growth Regulation, Telomere Maintenance and Human Diseases
Catalog Number: 3718
Kun Ping Lu (Medical School) 2607

*Cell Biology 358. Mechanisms of Tumor Metastasis
Catalog Number: 0606
Bruce R. Zetter (Medical School) 7737

*Cell Biology 359. Intracellular Signaling Pathways in the Regulation of Cell Growth and Differentiation
Catalog Number: 0335
David A. Frank (Medical School) 3276

*Cell Biology 360. Regulation and Execution of Apoptosis during Development in Drosophila
Catalog Number: 6046
Kristin White (Medical School) 3955

*Cell Biology 361. Matrix Biology, Cell-Matrix Interactions in Health and Disease
Catalog Number: 5561
Raghu Kalluri (Medical School) 4945

*Cell Biology 362. Molecular Basis of Pulmonary Hypertension, Hypoxia, Inflammation, and Stem Cell Biology
Catalog Number: 4662
Stella Kourembanas (Medical School) 4958

*Cell Biology 364. The Structure of the Nucleus and the Dynamics of Nuclear Transport
Catalog Number: 3582
Frank D. McKeon (Medical School) 1990

*Cell Biology 369. Genetics, Epigenetics, Molecular Biology, Chromatin
Catalog Number: 1452
Andrew J. Chess (Medical School) 5662

*Cell Biology 370. Mitotic Kinases, Chromatin and Chromosome Segregation
Catalog Number: 0661
Jonathan M. G. Higgins (Medical School) 5543

*Cell Biology 371. Nutrient Sensing and Metabolic Control
Catalog Number: 5804
Pere B. Puigserver (Medical School) 5735

*Cell Biology 372. Cytoskeletal Dynamics
Catalog Number: 5032
Timothy J. Mitchison (Medical School) 3713

*Cell Biology 373. Molecular Genetics of Cell Interaction in Development
Catalog Number: 8133
Spyros Artavanis-Tsakonas (Medical School) 2609

*Cell Biology 376. Chemical Approaches to Cell Division and Cancer
Catalog Number: 7680
Randy King (Medical School) 3941

*Cell Biology 377. Stem Cells, Islet Cell Function, Growth and Development
Catalog Number: 7966
Rohit N. Kulkarni (Medical School) 5152

*Cell Biology 378. Bacterial Toxin Entry and Immunoglobulin Transport in Mucosal Epithelial Cells
Catalog Number: 7656
Wayne I. Lencer (Medical School) 5153

*Cell Biology 379. BMP Signaling in Organogenesis
Catalog Number: 2894
Vicki Rosen (Dental School) 4790

*Cell Biology 380. Cytoskeletal Mechanics of Blood Platelet Production
Catalog Number: 9706
Joseph E. Italiano (Medical School) 5392

*Cell Biology 381. Molecular Mechanism of Microtubule-based Motility
Catalog Number: 8578
Samara Louise Reck-Peterson (Medical School) 6165

*Cell Biology 383. Molecules and Pathways that Control Instinctive Behaviors
Catalog Number: 8119
Stephen Daniel Liberles (Medical School) 6159

*Cell Biology 399. Nanocourses
Catalog Number: 0087
David Lopes Cardozo (Medical School) 5995 and Spyros Artavanis-Tsakonas (Medical School) 2609

Developmental and Regenerative Biology

Graduate Course

*Developmental & Regenerative Biology 311. Cardiovascular Stem Cell Biology - (New Course)
Catalog Number: 50682
Caroline Erter Burns 6516

*Developmental & Regenerative Biology 312. Epigenetic Modifications and Cellular Identity - (New Course)
Catalog Number: 65789
Alexander Meissner 6702

*Developmental & Regenerative Biology 313. Liver Development, Regeneration and Carcinogenesis - (New Course)
Catalog Number: 14267
Wolfram Goessling 6563

*Developmental & Regenerative Biology 314. Molecular and Developmental Neurobiology - (New Course)
Catalog Number: 80896
Paola Arlotta 6703

*Developmental & Regenerative Biology 315. Molecular Genetics of Organ Development - (New Course)
Catalog Number: 29374
Susan Mango 6386

*Developmental & Regenerative Biology 317. Stem cells, Cancer, and Hematological Disorders - (New Course)
Catalog Number: 44481
Catherine T. Yan 6517

Genetics

Primarily for Graduates

Genetics 202. Principles of Genetic Analysis in Humans
Catalog Number: 8064 Enrollment: Limited to 30.
Raju Kucherlapati (Medical School) and members of the Department
Half course (spring term). Tu., Th., 10:30–12.
Comprehensive examination of the principles of human inheritance, in the context of both normal human variation and disease. Topics include human genome structure, sequence variation, population genetics, complex traits, association studies, and pharmacogenetics.
Prerequisite: Genetics 201 (or permission of the instructor) and basic knowledge of probability and statistics. Familiarity with bioinformatics and computational tools will be useful, but tutorial assistance will be provided where necessary.

Genetics 216. Advanced Topics in Gene Expression
Catalog Number: 2244
Robert E. Kingston (Medical School) and Fred Winston (Medical School)
Half course (spring term). Tu., 1–4.
Covers both biochemical and genetic studies in regulatory mechanisms. Small number of topics discussed in depth, using the primary literature. Topics range from prokaryotic transcription to eukaryotic development.
Note: Offered jointly with the Medical School as GN 703.0.
Prerequisite: BCMP 200 and Genetics 201.

Genetics 219. Inheritance - (New Course)
Catalog Number: 14189
Chao-Ting Wu (Medical School), Kamran Ahmad (Medical School), David Emil Reich (Medical School) and members of the Department
Half course (fall term). Tu., 10–1.
Lectures/discussions will focus on surprising patterns of inheritance, including those resulting from chromosome rearrangements (CNVs, translocations, etc.) and phenomena that were recently considered extraordinary but are now recognized as general paradigms spanning fungi to humans.
Prerequisite: Primarily for first-year graduate students, but is open to medical students and advanced undergraduates. A basic understanding of genetics recommended.

Genetics 220. Molecular Biology and Genetics in Modern Medicine
Catalog Number: 4660
Anne Giersch (Medical School)
Half course (fall term). F., 9:30–12:30, Tu., Th., 2–5.
Scientific, clinical, and ethical aspects of modern human genetics and molecular biology as applied to medicine. Covers genetic approaches and molecular underpinnings of inherited diseases and somatic/genetic diseases are integrated with patient presentations, discussions.
Note: Offered jointly with the Medical School as HT 160.

Genetics 228. Genetics in Medicine - From Bench to Bedside
Catalog Number: 9840 Enrollment: Limited to 15.
Susan A. Slaugenhaupt (Medical School) and Christopher Holmes Newton-Cheh
Half course (fall term). F., 2–5.
Focus on translational medicine: the application of basic genetic discoveries to human disease. Will discuss specific genetic disorders and the approaches currently used to speed the transfer of knowledge from the laboratory to the clinic.
Note: Course will include clinical presentations and lectures by investigators known for their work in a specific disease area. Course will be held at MGH (transportation provided to MGH). Offered jointly with the Medical School as GN 711.0. For more information visit: www.mgh.harvard.edu/bbs.
Prerequisite: Genetics 201 or equivalent.

Graduate Courses of Reading and Research

[*Genetics 301. Research in Molecular Genetics and Molecular Oncology]
Catalog Number: 4780
Philip Leder (Medical School) 7527
Note: Expected to be given in 2010–11.

*Genetics 303. Pathogenesis
Catalog Number: 1972
Frederick Ausubel (Medical School) 4639

*Genetics 304. Molecular Genetics Basis of Human Disease, Particularly Cardiovascular Pathogenesis
Catalog Number: 0693
Christine E. Seidman (Medical School) 3013

*Genetics 305. Genetics, Receptors and Ion Channels
Catalog Number: 9027
Jing Zhou (Medical School) 3779

*Genetics 306. Inherited Human Disorders
Catalog Number: 7324
Jonathan G. Seidman (Medical School) 7529

*Genetics 308. Molecular Biology of Signal Transduction
Catalog Number: 5616
Brian Seed (Medical School) 7619

*Genetics 309. Gene Expression in Yeast
Catalog Number: 3763
Fred Winston (Medical School) 7877

*Genetics 310. Molecular Approaches to Developmental Neurobiology
Catalog Number: 6324
Constance L. Cepko (Medical School) 1150

*Genetics 311. Molecular Mechanisms of Transcription Regulation in Mammals
Catalog Number: 7310
Robert E. Kingston (Medical School) 1153

*Genetics 312. Molecular Genetics of Development
Catalog Number: 8363
Gary B. Ruvkun (Medical School) 1366

*Genetics 313. Genomic Approaches to Human Disease Genetics
Catalog Number: 6059
David M. Altshuler (Medical School) 4307

*Genetics 314. Structure and Activities of Ribozymes
Catalog Number: 7244
Jack Szostak (Medical School) 7096

*Genetics 315. Molecular Genetics of Inherited Disorders
Catalog Number: 3362
James Gusella (Medical School) 1152

*Genetics 316. Transcriptional Regulatory Network Analyses
Catalog Number: 2247
Martha L. Bulyk (Medical School) 4259

*Genetics 317. Signaling Networks in Development and Disease
Catalog Number: 2271
Jordan A. Kreidberg (Medical School) 2080

*Genetics 318. Genome Structure
Catalog Number: 5012
George M. Church (Medical School) 1608

*Genetics 319. Mouse Models of Human Disorders
Catalog Number: 0860
David R. Beier (Medical School) 3519

*Genetics 320. Genetics of Common Human Disease - (New Course)
Catalog Number: 39071
Mark Daly 6519

*Genetics 321. Genetics of Embryonic Development in Drosophila
Catalog Number: 6501
Norbert Perrimon (Medical School) 1679

*Genetics 322. Vertebrate Pattern Formation
Catalog Number: 0436
Clifford J. Tabin (Medical School) 2430

*Genetics 323. Molecular Biology of V(D)J Recombination
Catalog Number: 6950
Marjorie A. Oettinger (Medical School) 3172

*Genetics 324. Genetic Basis of Human Complex Diseases - (New Course)
Catalog Number: 54178
Paul I Wen de Bakker 6404

*Genetics 325. Human Genetics, Genomics and Complex Traits
Catalog Number: 8275
Joel N. Hirschhorn (Medical School) 4321

*Genetics 326. Human, Molecular and Mouse Genetics
Catalog Number: 2900
David J. Kwiatkowski (Medical School) 3770

*Genetics 327. Systems Biology of Mammalian Cell Fate Decisions - (New Course)
Catalog Number: 69285
Suzanne Gaudet (Medical School) 6183

*Genetics 328. Lymphocyte Differentiation, Recombination, and Nuclear Oncogenes
Catalog Number: 2702
Frederick W. Alt (Medical School) 3146

*Genetics 329. Genetic Analysis of Synaptic Transmission
Catalog Number: 9734
Joshua M. Kaplan (Medical School) 3522

*Genetics 330. Critical Thinking and Research Proposal Writing
Catalog Number: 0210 Enrollment: Limited to 20.
Monica P. Colaiacovo (Medical School) 4949 and members of the Faculty
Half course (spring term). Hours to be arranged.
A small group tutorial systematically guiding students in the writing of original, hypothesis-driven research proposals from initial topic selection through completion of a final draft.
Note: Open to all BBS students; others need permission of the instructor.
Prerequisite: Core course in genetics, cell biology, molecular biology, or biochemistry.

*Genetics 331. Developmental Oncobiology and Cancer Stem Cells - (New Course)
Catalog Number: 17763
Zhe Li 6408

*Genetics 332. Combining Genetic and Biochemical Approaches to Dissect Tumor Suppressor Gene Function
Catalog Number: 2975
Karen M. Cichowski (Medical School) 3932

*Genetics 333. Human Genome Structural and Regulatory Variation - (New Course)
Catalog Number: 84392
Mark Daly 6519

*Genetics 334. Genomics and the Genetics of Human Disease
Catalog Number: 5144
Raju Kucherlapati (Medical School) 4324

*Genetics 335. Epigenetics, Homolgy Effects, Genetics, and Gene Regulation
Catalog Number: 4982
Chao-Ting Wu (Medical School) 3535

*Genetics 336. Developmental Biology of Hematopoiesis
Catalog Number: 7165
Leonard I. Zon (Medical School) 1137

*Genetics 337. Human Molecular Genetics
Catalog Number: 7194
Stuart H. Orkin (Medical School) 7402

[*Genetics 340. A Genetic Approach to Iron Biology]
Catalog Number: 2936
Nancy Andrews (Medical School) 1589
Note: Expected to be given in 2010–11.

*Genetics 341. Development and Homeostasis of the Skeleton
Catalog Number: 8874
Matthew L. Warman (Dental School) 5875

*Genetics 342. Genetic Analysis of Zebrafish Kidney Organogenesis
Catalog Number: 4498
Iain A. Drummond (Medical School) 5350

*Genetics 344. Computational Genomics
Catalog Number: 2125
Peter J. Park (Medical School) 5917

*Genetics 350. Genetic Regulation of Organogenesis and Organ Regeneration
Catalog Number: 4974
Richard L. Maas (Medical School) 3703

*Genetics 351. Drosophila, a Model Genetic System to Study Signal Transduction
Catalog Number: 4998
Lizabeth A. Perkins (Medical School) 1604

*Genetics 353. Genetics of Human Disease
Catalog Number: 6608
Susan A. Slaugenhaupt (Medical School) 5483

*Genetics 354. Integrative Genomics of Cancer and Development - (New Course)
Catalog Number: 53387
Isaac S. Kohane (Medical School) 4531

*Genetics 355. Molecular Genetics of Human Neuromuscular Diseases
Catalog Number: 9253
Alan H. Beggs (Medical School) 1422

*Genetics 357. Lung Stem Cell Biology and Cancer
Catalog Number: 9494
Carla Kim (Medical School) 5742

*Genetics 358. Mammalian Embryonic Patterning
Catalog Number: 8297
Susan M. Dymecki (Medical School) 1736

*Genetics 359. Cancer and Development, Thrombopoiesis, Intestinal Development
Catalog Number: 9880
Ramesh Arjun Shivdasani (Medical School) 4538

*Genetics 360. Microtubule Associated RNAs During Mitosis
Catalog Number: 5677
Michael Demian Blower (Medical School) 5733

*Genetics 361. Mechanism of X-inactivation in Mammals
Catalog Number: 9152
Jeannie T. Lee (Medical School) 2129

*Genetics 362. Molecular Biology and Genetics of Cancer
Catalog Number: 9382
David Morse Livingston (Medical School) 4872

[*Genetics 363. Cell Polarity in the Vertebrate Embryo]
Catalog Number: 8658
Instructor to be determined
Note: Expected to be given in 2010–11.

*Genetics 364. Development Application of Mammalian Vectors
Catalog Number: 7930
Richard C. Mulligan (Medical School) 2274

*Genetics 365. Organogenesis of the Kidney
Catalog Number: 9059
Alan J. Davidson (Medical School) 5668

*Genetics 366. Molecular Genetic Approaches to Human Disease Mechanisms
Catalog Number: 8153
Marcy E. MacDonald (Medical School) 2635

*Genetics 367. Mechanisms Governing Normal Cell Growth, Cancer and Aging
Catalog Number: 2500
Ronald A. DePinho (Medical School) 2637

*Genetics 369. Molecular Mechanisms of Plant Signal Transduction
Catalog Number: 3010
Jen Sheen (Medical School) 3892

*Genetics 370. Molecular Basis of Breast Cancer Initiation and Progression
Catalog Number: 4519
Kornelia Polyak (Medical School) 3898

*Genetics 371. To Generate a Comprehensive Protein-Interaction Map for C. elegans and Develop New Concepts to Integrate this Map with Other Functional Maps such as Expression Profiles and Global Phenotypic Analysis
Catalog Number: 2190
Marc Vidal (Medical School) 3914

*Genetics 373. Kidney Disease, Genetics, Cytoskeleton
Catalog Number: 3875
Martin R. Pollak (Medical School) 4329

*Genetics 374. Research On Mechanisms Underlying Meiotic Chromosome Segregation
Catalog Number: 4419
Monica P. Colaiacovo (Medical School) 4949

*Genetics 375. Genomics of Leukemia
Catalog Number: 2335
Scott A. Armstrong (Medical School) 4947

*Genetics 376. Cell Cycle Control and Genomic Integrity
Catalog Number: 3788
Stephen J. Elledge (Medical School) 4954

*Genetics 377. Molecular Genetics of Chromosome Organization and Gene Expression
Catalog Number: 0811
Mitzi I. Kuroda (Medical School) 4959

*Genetics 379. Applying Population Genetics to Find Disease Genes
Catalog Number: 1677
David Emil Reich (Medical School) 4965

*Genetics 380. Molecular Approaches to Metabolism and Energy Balance
Catalog Number: 4688
Evan David Rosen (Medical School) 4966

*Genetics 381. Genetics of Psychiatric Disorders
Catalog Number: 1377
Pamela B. Sklar (Medical School) 5154

*Genetics 382. Muscle Stem Cell Commitment and Differentiation
Catalog Number: 2626
Emanuela Gussoni (Medical School) 5155

*Genetics 383. Germ Cell Development, Pluripotency and Epigenetic Reprogramming
Catalog Number: 2862
Niels Geijsen (Medical School) 5386

*Genetics 384. Cardiogenesis and Cardiac Morphogenesis
Catalog Number: 7079
William T. Pu (Medical School) 5396

*Genetics 386. Models of Cardiac Development and Disease
Catalog Number: 1127
John David Mably (Medical School) 6160

*Genetics 387. Stem Cells and Developmental Biology
Catalog Number: 4080
Chad A. Cowan 6099

*Genetics 390. Experimental Approaches in Genetic Analysis
Catalog Number: 8039 Enrollment: Limited to 8.
Fred Winston (Medical School) 7877 and members of the Department
A survey of major themes in genetics combined with exposure to various experimental techniques, technologies, and model systems. Combines lectures and hands-on laboratory activities emphasizing experimental methods, hypothesis generation and testing, and data analysis.
Note: Limited to 8 students. Priority will be given to first year graduate students. Students must first contact Sarah Wojiski (sarah wojiski@hms.harvard.edu) or 2-7468 for enrollment approval prior to registration for the course. Meeting Dates/Times: Approximately 8:30 am-7:00 pm each day for 14 days in January.
Prerequisite: Students must also enroll in, or have taken Genetics 201.

Human Biology and Translational Medicine

Graduate Courses of Reading and Research

*Human Biology and Translational Medicine 302. Molecular Cellular Pathophysiology of Ion Transport
Catalog Number: 3462
Seth L. Alper (Medical School) 1275

*Human Biology and Translational Medicine 303. Cystic Fibrosis and Fatty Acid Metabolism
Catalog Number: 5376
Steven D. Freedman (Medical School) 5921

*Human Biology and Translational Medicine 304. Resolution of Lung Inflammation and Injury
Catalog Number: 1421
Bruce D. Levy (Medical School) 5922

*Human Biology and Translational Medicine 305. Endothelial Cell, Nitric Oxide, Proteomic Redox Regulation
Catalog Number: 9077
Joseph Loscalzo (Medical School) 5923

*Human Biology and Translational Medicine 306. Cardiovascular Disease, Diabetes, Biomarkers, Women’s Health
Catalog Number: 2876
JoAnn Manson (Medical School) 5924

*Human Biology and Translational Medicine 307. Signal Transduction in Heart Failure and Atherosclerosis
Catalog Number: 1294
Anthony Rosenzweig (Medical School) 5925

*Human Biology and Translational Medicine 308. Cancer Biology: Metabolism
Catalog Number: 5913
Vikas P. Sukhatme (Medical School) 1835

*Human Biology and Translational Medicine 309. Energy Metabolism and Metabolic Signaling
Catalog Number: 4331
Rong Tian (Medical School) 5926

*Human Biology and Translational Medicine 310. Bioimaging, Nanomaterials and Systems Biology
Catalog Number: 4536
Ralph Weissleder (Medical School) 5927

*Human Biology and Translational Medicine 311. Kidney Injury and Repair
Catalog Number: 2495
Joseph Vincent Bonventre (Medical School) 5957

*Human Biology and Translational Medicine 312. The Development, Physiology, and Pathophysiology of GnRH Neurons in Humans
Catalog Number: 7114
William Francis Crowley (Medical School) 5958

*Human Biology and Translational Medicine 313. Epidemiology of Chronic Diseases
Catalog Number: 2036
Gary Craig Curhan (Medical School) 5959

*Human Biology and Translational Medicine 314. Skin Immunology T Cell Trafficking Lymphoma
Catalog Number: 2368
Thomas Seth Kupper (Medical School) 5960

*Human Biology and Translational Medicine 315. Hypothalamic Gene Function and Regulation
Catalog Number: 1577
Joseph A. Majzoub (Medical School) 1875

*Human Biology and Translational Medicine 316. Innovative Medical Devices and Procedures
Catalog Number: 9233
John Albert Parrish (Medical School) 5961

*Human Biology and Translational Medicine 317. Adhesion, Integrins, Hematopoiesis, Kidney Genetics
Catalog Number: 5746
M. Amin Arnaout (Medical School) 1822

*Human Biology and Translational Medicine 318. Steroid Hormone Receptors and Prostate Cancer
Catalog Number: 7992
Steven Paul Balk (Medical School) 6166

*Human Biology and Translational Medicine 319. Molecular Regulation of Granulocyte Differentiation
Catalog Number: 4496
Nancy Berliner (Medical School) 6167

*Human Biology and Translational Medicine 320. Endothelial Progenitors in Health Disease
Catalog Number: 8324
Joyce E. Bischoff (Medical School) 1448

*Human Biology and Translational Medicine 321. Cardiac Regeneration and Repair
Catalog Number: 2455
Richard Theodore Lee (Medical School) 6168

*Human Biology and Translational Medicine 322. Cardiac Repair and Regeneration
Catalog Number: 4398
Ronglih Liao (Medical School) 6169

*Human Biology and Translational Medicine 323. Cardiovascular Biology in Human and Zebrafish
Catalog Number: 5160
Calum Archibald MacRae (Medical School) 6170

*Human Biology and Translational Medicine 324. Engineering of Human Antibodies
Catalog Number: 3910
Wayne A. Marasco (Medical School) 6171

*Human Biology and Translational Medicine 325. Genetics of Blood Development
Catalog Number: 7279
Barry Htin Paw (Medical School) 6172

*Human Biology and Translational Medicine 326. Human Genetics of Neuroinflammatory and Neurodegenerative Disorders
Catalog Number: 1515
Philip Lawrence De Jager (Medical School) 6233

*Human Biology and Translational Medicine 327. Translational Research on Kinase Inhibitors
Catalog Number: 0138
Pasi Antero Janne (Medical School) 6234

*Human Biology and Translational Medicine 328. Translational Immunology In Immunocompromised Hosts
Catalog Number: 8917
Ofer Levy (Medical School) 6236

*Human Biology and Translational Medicine 329. Developing Targeted Therapies for Cancer
Catalog Number: 6232
Jeffrey Adam Engelman (Medical School) 6225

*Human Biology and Translational Medicine 330. Developmental Biology/Genetics (Congenital Anomalies, Cancer)
Catalog Number: 8982
Patricia K. Donahoe (Medical School) 3252

*Human Biology and Translational Medicine 331. Tumor Microenvironment, Angiogenesis and Metastasis: From Bench-to-Bedside and Back
Catalog Number: 8347
Rakesh K. Jain (Medical School) 2079

*Human Biology and Translational Medicine 340. (LHB). Disease-Centered Tutorial Clinics
Catalog Number: 8640 Enrollment: Limited to LHB students only.
Jordan A. Kreidberg (Medical School) 2080

*Human Biology and Translational Medicine 341. Gene Regulation of Metabolism in Cardiovascular Health and Disease - (New Course)
Catalog Number: 99499
Zoltan Pierre Arany 6409

*Human Biology and Translational Medicine 342. Research in Hematology and Oncology - (New Course)
Catalog Number: 47977
Benjamin L. Ebert 6410

*Human Biology and Translational Medicine 343. Complex Trait Genetics of Blood Pressure and QT Interval Variation - (New Course)
Catalog Number: 63084
Christopher Holmes Newton-Cheh 6270

*Human Biology and Translational Medicine 344. Biology of Hematopoietic Stem Cells - (New Course)
Catalog Number: 11562
David Allen Williams 6460

Immunology

Primarily for Graduates

Immunology 202. Advanced Principles of Immunology
Catalog Number: 5674
D. Branch Moody (Medical School) and Martin E. Hemler (Medical School)
Half course (spring term). Tu., Th., 1:30–4.
Continuation of Immunology 201 as an intensive core course in fundamentals of the immune system. Emphasis on systems of immunity. Critical reading of primary literature.
Note: Offered jointly with the Medical School as IM 712.0.
Prerequisite: Immunology 201 or its equivalent.

Immunology 204. Critical Readings for Immunology
Catalog Number: 9563
Shannon Turley (Medical School) and Carl D. Novina (Medical School)
Half course (spring term). Th., 10–1.
Original research articles from fields including immunology, biochemistry, genetics, and cell and developmental biology will be critically analyzed in an intensive small group format. Grading will be based on class participation and oral presentations.
Note: Required for first-year immunology students, open to second-year immunology students. No auditors. Offered jointly with the Medical School as IM 703.0.

*Immunology 219. The Primary Immunodeficiencies
Catalog Number: 1873
Cox Terhorst (Medical School), Raif S. Geha (Medical School), and Luigi D. Notarangelo (Medical School)
Half course (spring term). M., 4–6.
This course discusses the mechanisms that underlie the pathogenesis of genetically determined primary immunodeficiencies and selected autoimmune diseases. Evaluates the use of animal models for study and therapy of human disease states.
Note: Offered jointly with the Medical School as IM 729.0.
Prerequisite: Course in basic immunology.

Graduate Courses of Reading and Research

*Immunology 301. Immunology Seminar
Catalog Number: 4971 Enrollment: Limited to 20.
Michael C. Carroll (Medical School) 2050
Gives students exposure to research topics in Immunology. Students prepare for the weekly seminar through readings and occasional discussion with the seminar speakers. These discussions are facilitated by members of the Committee on Immunology.
Note: Intended for first- and second-year Immunology graduate students.

*Immunology 302. Molecular Basis of Humoral Immunologic Inflammation
Catalog Number: 1355
K. Frank Austen (Medical School) 1571

*Immunology 303. Immunity to Tuberculosis
Catalog Number: 9490
Samuel M. Behar (Medical School) 4570

[*Immunology 306. Immunochemical Aspects of Immune Reactions]
Catalog Number: 1536
Stuart F. Schlossman (Medical School) 3593
Note: Expected to be given in 2010–11.

*Immunology 307. Immunobiology of Transplantation
Catalog Number: 1609
Charles B. Carpenter (Medical School) 2016

*Immunology 308. Gene Regulation in the Immune Response
Catalog Number: 6895
Anjana Rao (Medical School) 1854

*Immunology 309. Molecular Aspects of Lymphocyte Interactions
Catalog Number: 3778
Cox Terhorst (Medical School) 6280

*Immunology 314. Immunobiology of Antigen-Antibody Complexes
Catalog Number: 8065
Peter H. Schur (Medical School) 4551

*Immunology 315. Immunoregulation
Catalog Number: 5540
Martin E. Dorf (Medical School) 4541

*Immunology 316. Molecular Basis of Immunologic Recognition and Communication
Catalog Number: 3192
Harvey Cantor (Medical School) 4460

*Immunology 317. Molecular Biology of Receptor Transduction in the Immune System
Catalog Number: 0518
Brian Seed (Medical School) 7619

*Immunology 319. Molecular Basis of Cell Adhesion and Migration
Catalog Number: 0293
Timothy A. Springer (Medical School) 6145

*Immunology 323. Research in Molecular Immunology
Catalog Number: 3425
Laurie H. Glimcher (Public Health) 1362

*Immunology 324. T-cell Development in Animal Models of Autoimmunity Disease
Catalog Number: 1905
Christophe O. Benoist (Medical School) 3928

*Immunology 325. Immune Cell Interactions Controlling T Cell Effector Function
Catalog Number: 1078
Thorsten Roman Mempel (Medical School) 6173

*Immunology 326. Human T-cell Antigen Receptor; Human Lymphocyte Differentiation Antigens
Catalog Number: 6719
Ellis L. Reinherz (Medical School) 1408

*Immunology 327. Chemical Cell Biology
Catalog Number: 0824
Stuart L. Schreiber 2166

*Immunology 328r. Introduction to Research
Catalog Number: 5531
Michael C. Carroll (Medical School) 2050

*Immunology 329. Basic and Clinical Mechanisms of Autoimmunity
Catalog Number: 0354
Howard L. Weiner (Medical School) 1335

*Immunology 330. Molecular Aspects of Mast Cells—Mediated Immune Responses
Catalog Number: 7296
Richard L. Stevens (Medical School) 2892

*Immunology 331. Lymphoid Organs
Catalog Number: 5725
Joan E. Stein-Streilein (Medical School) 4769

*Immunology 332. The Role of Cys-Lts in Antigen-Induced Pulmonary Inflammation and the Mechanism of Cys-LT-Mediated Pulmonary Fibrosis
Catalog Number: 9530
Yoshihide Kanaoka (Medical School) 5401

*Immunology 333. Immunopathogenesis of Viral Diseases
Catalog Number: 2430
Norman Letvin (Medical School) 2317

[*Immunology 335. T-Cell Receptor Interactions in Autoimmune Diseases]
Catalog Number: 4027
David Hafler (Medical School) 2616
Note: Expected to be given in 2010–11.

*Immunology 336. T-Lymphocyte Recognition and Adhesion
Catalog Number: 7292
Michael B. Brenner (Medical School) 2864

*Immunology 337. Development of Mucosal Immunologic Factor
Catalog Number: 1320
W. Allan Walker (Medical School, Public Health) 1175

*Immunology 339. Function and Regulation of Cellular Adhesion Mechanisms
Catalog Number: 7841
Martin E. Hemler (Medical School) 2868

*Immunology 340. The Human Major Histocompatibility Complex, Immune Function, and Disease
Catalog Number: 6650
Chester Alper (Medical School) 2951

*Immunology 341. Transcriptional Regulation of Stem Cell and Myeloid Cell Genes in Order to Understand Normal Myeloid Differentiation and Leukemia
Catalog Number: 9403
Daniel G. Tenen (Medical School) 1172

*Immunology 342. Immune Cell Signaling, Gene Transcription and Tissue Injury in Lupus.
Catalog Number: 7829
George C. Tsokos (Medical School) 5911

*Immunology 343. The Regulation of Eicosanoid Generation
Catalog Number: 8593
Jonathan P. Arm (Medical School) 4946

*Immunology 344. Genetic Analysis of Lymphocyte Development and Nuclear Oncogene Function
Catalog Number: 6438
Frederick W. Alt (Medical School) 3146

*Immunology 345. Assembly and Function of pre-B Cell-fate and B Lymphocyte Antigen Receptors
Catalog Number: 0866
Shiv S. Pillai (Medical School) 3393

*Immunology 346. The Role of Complement in the Immune Response
Catalog Number: 1755
Michael C. Carroll (Medical School) 2050

*Immunology 347. Mechanisms Underlying the Unique Ability of Antigen Presenting Cells to Activate Naive T Lymphocytes
Catalog Number: 9833
Marianne Boes (Medical School) 5385

*Immunology 348. Cell Biology, Biochemistry, and Immunology of Leukocyte-endothelial Adhesion
Catalog Number: 0901
Francis W. Luscinskas (Medical School) 3772

*Immunology 349. Mechanisms of T Cell and NK Cell Tolerance
Catalog Number: 1241
Megan Sykes (Medical School) 1131

*Immunology 350. Regulation of Autoimmune T Cell Responses
Catalog Number: 1916
Vijay K. Kuchroo (Medical School) 2041

*Immunology 351. Studies on Trafficking of Lymphocytes to Skin and of Tumor Cells to Organ-Specific Sites of Metastasis
Catalog Number: 1875
Charles J. Dimitroff (Medical School) 5521

*Immunology 352. Using Biochemical, Cellular and Mouse Genetics Approaches to Dissect the Innate Immune Signaling Pathways of Toll-like Receptors and NBD-LRR (Nod) Proteins
Catalog Number: 1572
Koichi S. Kobayashi (Medical School) 5522

*Immunology 353. Innate and Adaptive Immune Responses in HIV-1 Infection
Catalog Number: 6000
Marcus Altfeld (Medical School) 5689

*Immunology 354. Topics in Transplantation Biology
Catalog Number: 1459
David H. Sachs (Medical School) 1075

*Immunology 356. Cytotoxic T Lymphocytes
Catalog Number: 8232
Judy Lieberman (Medical School) 1542

*Immunology 357. T Cell-Epithelial Cell Interactions in Mucosal Community
Catalog Number: 2111
Richard S. Blumberg (Medical School) 2351

*Immunology 358. Self-renewal and Lineage Commitment of Hematopoietic Stem Cells
Catalog Number: 1619
Koichi Akashi (Medical School) 5288

*Immunology 359. Immunoregulatory Mechanisms Affecting the Development of Pulmonary Inflammation, Asthma, and Allergy in Mice and Humans
Catalog Number: 3037
Dale T. Umetsu (Medical School) 5289

*Immunology 360. Focus on Stem Cells and the Stem Cell Niche
Catalog Number: 8952
David T. Scadden 2649

*Immunology 361. Induction and Regulation of Antigen-specific T Cell Responses
Catalog Number: 7578
Gilles A. Benichou (Medical School) 2652

*Immunology 362. Basic Biology and Pathobiology of the Chemokine Superfamily of Cytokines
Catalog Number: 3817
Andrew D. Luster (Medical School) 2654

*Immunology 363. Regulation of Mast Cell Activation by Stimulatory and Inhibitory Receptors
Catalog Number: 6813
Howard R. Katz (Medical School) 2837

*Immunology 364. T-Cell Development in Animal Models of Autoimmunity Disease
Catalog Number: 0972
Diane J. Mathis (Medical School) 3063

[*Immunology 365. Mucosal T Cell Mediated Immunity and Tolerance ]
Catalog Number: 4204
Cathryn R. Nagler (Medical School) 1022
Note: Expected to be given in 2010–11.

*Immunology 366. Molecular Regulation of T Cell Cytokine Production and T Cell Interactions with the Blood Vessel Wall
Catalog Number: 6676
Andrew H. Lichtman (Medical School) 3523

*Immunology 367. Biology and Chemistry of Complement Problems
Catalog Number: 8080
Anne Nicholson-Weller (Medical School) 1063

*Immunology 368. Cytotoxic Lymphocytes
Catalog Number: 8986
Paul J. Anderson (Medical School) 1947

*Immunology 369. Mechanisms of Autoimmune Disease
Catalog Number: 6787
Vicki R. Kelley (Medical School) 2656

*Immunology 370. Mechanisms of Autoimmunity in Inflammatory Arthritis
Catalog Number: 6285
David M. Lee (Medical School) 5915

*Immunology 371. Cellular and Molecular Mechanisms of Eosinophil and Other Leukocyte Involvement in Allergic Flammation
Catalog Number: 3716
Peter F. Weller (Medical School) 2657

*Immunology 373. Biology of Histocompatibility Systems in Man and Experimental Animals; Immunology of Aging
Catalog Number: 6317
Edmond J. Yunis (Medical School) 6036

*Immunology 374. Tumor Necrosis Factor-Alpha Gene Regulation in the Immunopathogenesis of AIDS and TB
Catalog Number: 4558
Anne E. Goldfeld (Medical School) 1008

*Immunology 375. Biology and Function of Immunoreceptors
Catalog Number: 0510
Jean-Pierre Kinet (Medical School) 2663

*Immunology 376. Regulation of IgE Reponses; Molecular Basis of Immunodeficienies
Catalog Number: 3618
Raif S. Geha (Medical School) 1795

[*Immunology 377. Regulation of T Helper Cell Differentiation ]
Catalog Number: 0458
Michael Grusby (Medical School) 1987
Note: Expected to be given in 2010–11.

*Immunology 378. Basic Mechanisms of T cell Mediated Autoimmune Diseases
Catalog Number: 2916
Kai Wucherpfennig (Medical School) 2481

*Immunology 379. Induction of Immunological Tolerance by Gene Therapy
Catalog Number: 9300
John J. Iacomini (Medical School) 2643

*Immunology 380. Control of Leukocyte Trafficking and the Immune Response By Chemokines and Other Cytokines
Catalog Number: 4872
Barrett J. Rollins (Medical School) 3775

*Immunology 381. Lymphocyte Development, Signaling, Immunoregulation
Catalog Number: 0839
Harald Von Boehmer (Medical School) 3302

*Immunology 382. AIDS Immunopathogenesis and Immune Reconstitution
Catalog Number: 0468
Robert P. Johnson (Medical School) 6125

*Immunology 383. Translational Approaches In Transplantation and Tumor Immunity
Catalog Number: 4590
Lee M. Nadler (Medical School) 3773

*Immunology 384. The Role of Cysteinyl Leukotrienes and Nucleotide Receptors in Control of Pulmonary Allergic Immunity
Catalog Number: 1056
Joshua A. Boyce (Medical School) 6230

*Immunology 385. Transcriptional Regulation of T Lymphocyte Activation and Differentiation
Catalog Number: 1243
I-Cheng Ho (Medical School) 2764

*Immunology 387. Microbial Pattern Recognition and Signaling in Innate Immunity
Catalog Number: 6065
Christine Kocks (Medical School) 5753

[*Immunology 388. Immunology and Molecular Biology of Schistosoma Mansoni]
Catalog Number: 5640
Donald A. Harn (Public Health) 2051
Note: Expected to be given in 2010–11.

*Immunology 389. Development of Cancer Vaccines
Catalog Number: 4106
Glenn Dranoff (Medical School) 1821

*Immunology 391. Transcription Factors in Lymphocyte Commitment and Differentiation
Catalog Number: 5285
Katia Georgopoulos (Medical School) 2070

*Immunology 392. Dendritic Cells and the Initiation of Immune Reponses; Genetic Analysis using Genome-Wide Mammalian RNAi Libraries
Catalog Number: 0298
Nir Hacohen (Medical School) 5157

*Immunology 393. The Role of the Transcription Factor NF-kB in Regulating Innate Inflammatory Responses
Catalog Number: 3287
Bruce H. Horwitz (Medical School) 5158

*Immunology 394. Cellular and Molecular Mechanisms by which CD1 Proteins Present Lipid Antigens to T Cells
Catalog Number: 0938
D. Branch Moody (Medical School) 5159

*Immunology 395. NKT and Other Immune Cell Subsets in Anti-Tumor & Anti-Viral Immunity
Catalog Number: 2491
Mark Adrian Exley (Medical School) 5749

*Immunology 396. The Fundamental Nature of and the Means to Produce T Cell Tolerance to Allo- and Auto-Antigens
Catalog Number: 1812
Terry B. Strom (Medical School) 5160

*Immunology 397. Antigen Processing and Presentation by Dendritic Cells in Autoimmunity and Cancer
Catalog Number: 3393
Shannon Turley (Medical School) 5255

*Immunology 398. The Role of Notch Signaling in Lymphoid Neoplasia
Catalog Number: 9151
Jon Christopher Aster (Medical School) 5750

*Immunology 399. Innate and Adaptive Immunity in Transplantation
Catalog Number: 3048
Yong-Guang Yang (Medical School) 6238

Medical Sciences

Primarily for Graduates

*Medical Sciences 250ab. Human Functional Anatomy
Catalog Number: 6946 Enrollment: Limited to 52. Minimum 25.
Lee Gehrke (Medical School)
Full course (fall term). Lectures, M., W., F., 1:30–2:30; laboratory, M., W., F., 2:30–6.
Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of embryology and bioengineering promote analytical approaches to understanding the body’s design.
Note: Open to qualified graduate students with permission of the course director. Offered jointly with the Medical School as HT 010. The first meeting of this course is September 2, 2009.

Graduate Courses of Reading and Research

*Medical Sciences 310. Advanced Topics in Medical Sciences
Catalog Number: 7449
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (seven weeks). Different topics are covered each term.
Note: Two seminars, which can be taken in different terms, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Medical Sciences 399. Topics in Medical Sciences
Catalog Number: 3197
David Lopes Cardozo (Medical School) 5995
Subject selected by students and faculty member.

Microbiology and Molecular Genetics

Primarily for Graduates

[Microbiology 201. Molecular Biology of the Bacterial Cell] - (New Course)
Catalog Number: 38739
David Z. Rudner (Medical School), Thomas G. Bernhardt (Medical School), Simon L. Dove (Medical School), and Ann Hochschild (Medical School)
Half course (spring term). Tu., Th., 10–11:30.
This course is devoted to bacterial structure, physiology, genetics, and regulatory mechanisms. The class consists of lectures and group discussions emphasizing methods, results, and interpretations of classic and contemporary literature.
Note: Expected to be given in 2010–11.

[Microbiology 202. Molecular Basis of Bacterial Pathogenesis and Host Response] - (New Course)
Catalog Number: 23632
John J. Mekalanos (Medical School), Marcia Goldberg (Medical School), Darren E. Higgins (Medical School), Jonathan C. Kagan (Medical School), and Stephen Lory (Medical School)
Half course (fall term). Tu., Th., 10–11:30.
Overview of classic paradigms in bacterial-host interactions. Discussions of pathogenic strategies and mechanisms used by representative bacterial pathogens during infection and innate and adaptive host immune defenses. Emphasis on the analysis of published work.
Note: Expected to be given in 2010–11.

*Microbiology 205. Mechanisms of Microbial Pathogenesis
Catalog Number: 2480 Enrollment: Limited to 40.
Clyde S. Crumpacker II (Medical School) and associates
Half course (fall term). Tu., Th., 8:30–1.
The mechanisms of bacterial, mycoplasmal, fungal, and viral pathogenesis are covered. Topics are selected for intrinsic interest and cover the spectrum of pathophysiologic mechanisms of the infectious process. Emphasis on pathogenesis at the molecular level.
Note: Offered jointly with the Medical School as HT 040.
Prerequisite: A background course in molecular biology is strongly encouraged.

[Microbiology 209. Molecular Biology of Bacteria]
Catalog Number: 2698 Enrollment: Limited to 12. Minimum of 8.
Roberto G. Kolter (Medical School)
Half course (spring term). Hours to be arranged. One meeting per week.
Provides in-depth coverage of bacterial development and genomics. Students research topics and prepare lectures. Lectures are followed by discussions of key publications. The specific topics covered vary every year depending on student interest.
Note: Expected to be given in 2010–11. Given in alternate years. Open to graduate and advanced undergraduate students. Contact the instructor at least two weeks before the start of spring term via email at rkolter@hms.harvard.edu. Offered jointly with the Medical School as MG 727.0.

Microbiology 210. A Microbial Planet - (New Course)
Catalog Number: 63006
Roberto G. Kolter (Medical School), Jon Clardy (Medical School), and Ann Pearson
Half course (spring term). Tu., Th., 10–11:30.
This course covers the broad spectrum of microbiology from biodiversity to the impact of microorganisms on geology, the environment, climate, and world health. Topics include the origins of life, biogeochemical cycles, microbial diversity, and ecology.

Microbiology 213. Social Issues in Biology
Catalog Number: 7905 Enrollment: Limited to 18.
Jonathan R. Beckwith (Medical School) and Roberto G. Kolter (Medical School)
Half course (spring term). Th., 1–4.
Readings, discussion of social/ethical aspects of biology: history, philosophy of science; evolution vs. creationism; genetics and race; women and science; genetic testing; stem cell research; science journalism; genetics and the law; scientists and social responsibility.
Note: Offered jointly with the Medical School as MG 722.0. Alternates yearly between the Longwood and the Cambridge Campuses.
Prerequisite: Some background in genetics.

Microbiology 230. Analysis of the Biological Literature
Catalog Number: 3791
Elaine A. Elion (Medical School), Welcome W. Bender (Medical School), Michael Demian Blower (Medical School), Alan B. Cantor (Medical School), Stephen J. Elledge (Medical School), Richard Ian Gregory (Medical School), William C. Hahn (Medical School), Kevin M. Haigis (Medical School), Marcia C. Haigis (Medical School), Edward E. Harlow (Medical School), Jonathan M. G. Higgins (Medical School), Jordan A. Kreidberg (Medical School), Cammie Lesser (Medical School), Andrea I. McClatchey (Medical School), David Pellman (Medical School), Adrian Salic (Medical School), Ramesh Arjun Shivdasani (Medical School), David A. Sinclair (Medical School), Kevin Struhl (Medical School), Sheila Thomas (Medical School), Amy J. Wagers, and Chao-Ting Wu (Medical School)
Half course (fall term). Tu., Th., 2:30–7:30 p.m.
Critical analysis of original research articles in intensive small group discussions. Analyze range of papers in biochemistry, genetics, microbiology, and cell and developmental biology in terms of context, hypotheses, methods, results and future experiments.
Note: This course is required for first year BBS students. Students who are not first year BBS should contact the course director (E.A.E.) to determine the available space and receive course materials in advance of class.

Graduate Courses of Reading and Research

*Microbiology 304. Molecular Pathogenesis of Streptococcal Infection
Catalog Number: 9527
Michael R. Wessels (Medical School) 4540

*Microbiology 305. Molecular Determinants of Intracellular Bacterial Pathogenesis
Catalog Number: 3190
Darren E. Higgins (Medical School) 2963

*Microbiology 307. Growth Factors and Signal Transduction
Catalog Number: 5726
Charles D. Stiles (Medical School) 4828

*Microbiology 308. Bacterial/ Host Interactions in Symbiosis and Pathogenesis
Catalog Number: 4217
Dennis L. Kasper (Medical School) 4815

*Microbiology 310. Bacterial Genetics of Tuberculosis and Tularemia
Catalog Number: 7652
Eric J. Rubin (Medical School) 4084

*Microbiology 311. Microbiology and Molecular Genetics
Catalog Number: 7402
Jonathan R. Beckwith (Medical School) 1173

*Microbiology 313. T-Lymphocyte Responses to Bacterial Pathogens
Catalog Number: 4959
Michael Starnbach (Medical School) 1816

*Microbiology 315. Biochemical Mechanisms Controlling Cell Growth and Differentiation
Catalog Number: 3273
Michael E. Greenberg (Medical School) 1400

*Microbiology 316. Host Pathogen Interactions
Catalog Number: 7769
Stephen Lory (Medical School) 4326

*Microbiology 317. Molecular Mechanisms in Pathogenesis
Catalog Number: 8985
John J. Mekalanos (Medical School) 7315

*Microbiology 318. RNA Structure, RNA-protein Interactions, and Translation-level Gene Regulation in RNA Viruses
Catalog Number: 1205
Lee Gehrke (Medical School) 8036

*Microbiology 320. Molecular Biology of Herpes Viruses
Catalog Number: 3967
David M. Knipe (Medical School) 7089

*Microbiology 321. Molecular Biology of Bacterial Interactions
Catalog Number: 2903
Roberto G. Kolter (Medical School) 7727

*Microbiology 322. Biochemistry of Bacterial Toxins
Catalog Number: 4970
R. John Collier (Medical School) 7972

*Microbiology 324. Bacterial Pathogenesis and Vaccine Development
Catalog Number: 3472
Gerald Pier (Medical School) 2853

*Microbiology 325. Signal Transduction, Host-Microbial Interactions and Immunology
Catalog Number: 2839
Scott Brian Snapper (Medical School) 4969

*Microbiology 326. Mobile Genetic Elements and Bacterial Pathogenicity
Catalog Number: 4703
Matthew K. Waldor (Medical School) 5919

*Microbiology 327. Molecular Biology and Evolution of Retroviruses
Catalog Number: 7939
Welkin E. Johnson (Medical School) 5354

*Microbiology 328. Molecular Biology of Epstein Barr Virus Infection and Transformation of B Lymphocytes
Catalog Number: 3188
Elliott D. Kieff (Medical School) 1858

*Microbiology 329. The Regulation of Gene Expression in Pathogenic Bacteria
Catalog Number: 5892
Simon L. Dove (Medical School) 4953

*Microbiology 330. Molecular Mechanisms in Bacterial Differentiation
Catalog Number: 5102
David Z. Rudner (Medical School) 4968

*Microbiology 331. Modeling Mechanisms of Bacterial Pathogenesis
Catalog Number: 1929
Cammie Lesser (Medical School) 4962

*Microbiology 332. Gene Regulation of Prokaryotes
Catalog Number: 0915
Ann Hochschild (Medical School) 2314

*Microbiology 334. Primate Lentiviral Immunology and Pathogenesis
Catalog Number: 8398
David T. Evans (Medical School) 5353

*Microbiology 335. Molecular Biology of Parasites
Catalog Number: 0528
Dyann F. Wirth (Public Health) 2492

*Microbiology 336. Pathogen-host Interactions
Catalog Number: 3981
Marcia Goldberg (Medical School) 3783

*Microbiology 337. Mycobacterial Signal Transduction and Transcription Regulation
Catalog Number: 5826
Robert Husson (Medical School) 5914

*Microbiology 339. Bacterial Cell Division and Cell Biology
Catalog Number: 7237
Thomas G. Bernhardt (Medical School) 5752

*Microbiology 340. Herpes Virus Transformation and Gene Transfer Vector
Catalog Number: 8544
Jae Ung Jung (Medical School) 2048

*Microbiology 343. Chemical Biology, Enzymology, Antibiotics, Glycosyltransferases, Inhibitors
Catalog Number: 2963
Suzanne Walker (Medical School) 5087

*Microbiology 344. Chemistry and Biology of Host-Virus Interactions
Catalog Number: 8853
Priscilla Yang (Medical School) 5156

*Microbiology 345. Pathogenesis of HIV-1 Transmission
Catalog Number: 0534
Manish Sagar (Medical School) 5664

*Microbiology 346. Genetics of Bacterial Adhesion and Pathogenesis
Catalog Number: 5690
Paula I. Watnick (Medical School) 5666

*Microbiology 347. Chemical Genetics Approach to Bacterial Pathogenesis
Catalog Number: 2308
Deborah Tan Hung (Medical School) 5701

*Microbiology 348. Toll-like Receptors and Innate Immunity
Catalog Number: 9708
Jonathan C. Kagan (Medical School) 6235

Neurobiology

Primarily for Graduates

Neurobiology 204. Neurophysiology of Central Circuits
Catalog Number: 5603
Rachel I. Wilson (Medical School), John A. Assad (Medical School), Richard T. Born (Medical School), Gabriel Kreiman (Medical School), Margaret S. Livingstone (Medical School), and John Maunsell (Medical School)
Half course (spring term). M., W., 10–12.
This course introduces major themes and fundamental concepts underlying current research in systems neuroscience. Each week covers a different theme, and draws on research from different sensorimotor modalities and model organisms.
Note: Offered jointly with the Medical School as NB 721.0.
Prerequisite: Neurobiology 200 or with permission of instructor.

Neurobiology 207. Developmental Neurobiology
Catalog Number: 4977 Enrollment: Limited to 20.
Lisa V. Goodrich (Medical School), Michela Fagiolini ((Medical School)), Chenghua Gu (Medical School), and Beth Stevens (Medical School)
Half course (spring term). F., 10–12, W., 2–4.
Advanced topics in nervous system development, including cell fate determination, axon guidance, synapse development and critical periods. Focus on current areas of investigation, unresolved questions, and common experimental approaches.
Note: Offered jointly with the Medical School as NB 720.0. Students will read and discuss primary literature in the discussion sessions. Emphasis will be given to learning how to identify an important question and develop a feasible research plan, including a lecture on how to write a grant proposal and a mock study section. The final exam consists of a grant proposal; grades will also be determined by successful completion of homework assignments and class participation.
Prerequisite: Neurobiology 200 or with permission of instructor.

Neurobiology 209. Neurobiology of Disease
Catalog Number: 5562
Edward A. Kravitz (Medical School) and Jang-Ho J. Cha
Half course (spring term). M., 6–8:30 p.m., W., 7–9:30 p.m.
Monday sessions involve patient presentations and “core” lectures describing clinical progression, pathology, and basic science underlying a major disease or disorder. Wednesdays, students present material from original literature sources, and there is general discussion.
Note: Given in alternate years. Offered jointly with the Medical School as NB 713.0. For advanced undergraduate, graduate students, MD and MD/PhD students.
Prerequisite: Introductory neurobiology, biochemistry, and genetics/molecular biology recommended.

*Neurobiology 220. Cellular Neurophysiology
Catalog Number: 2141
Bruce P. Bean (Medical School), Wade G. Regehr (Medical School), and Gary I. Yellen (Medical School)
Half course (fall term). Tu., Th., 9–12 and a weekly discussion section.
Introduction to the physiology of neurons. Topics include structure and function of ion channels, generation and propagation of action potentials, and physiology of synaptic transmission. Includes problem sets and reading of original papers.
Note: Offered jointly with the Medical School as NB 714.0.
Prerequisite: Introductory neurobiology.

Neurobiology 221. Molecular Neurobiology
Catalog Number: 0443
Charles J. Weitz (Medical School), Jonathan B. Cohen (Medical School), Bernardo L. Sabatini (Medical School), and Thomas L. Schwarz (Medical School)
Half course (spring term). Tu., Th., 10–12.
Molecular biology and genetics of the nervous system. Emphasis on importance of ligand-receptor interactions and receptor regulation for the function of the nervous system and on the mechanisms of storage and release of neurotransmitters.
Note: Offered jointly with the Medical School as NB 715.0.
Prerequisite: Introductory neurobiology and molecular biology. Permission of the instructor required for undergraduates.

Graduate Courses of Reading and Research

*Neurobiology 301. Visual Object Recognition: Molecules, Neurophysiology and Computation
Catalog Number: 8402
Gabriel Kreiman (Medical School) 6174

*Neurobiology 302. How Attention Influences Representation of Sensory Information in Cerebral Cortex, and How These Changes Improve Behavior Performance.
Catalog Number: 9850
John Maunsell (Medical School) 5670

*Neurobiology 303. Identification of Genes and Functional Pathways that Govern the Development, Function, and Disease State of the Inner Ear.
Catalog Number: 0660
Zheng-Yi Chen (Medical School) 5478

*Neurobiology 304. Chemistry of Synapses
Catalog Number: 5467
Edward A. Kravitz (Medical School) 2063

*Neurobiology 305. Cellular and Molecular Mechanisms of Epilepsy and Autism
Catalog Number: 1349
Matthew Peter Anderson (Medical School ) 6691

*Neurobiology 306. The Molecular Mechanisms of How Neural and Vascular Networks are Coordinately Developed, Communicate, and Evolve to Work in Concert During Normal and Disease States.
Catalog Number: 0992
Chenghua Gu (Medical School) 5479

*Neurobiology 308. Molecular Mechanisms of Catecholaminergic-specific Gene Regulation
Catalog Number: 6125
Kwang-Soo Kim (Medical School) 3046

*Neurobiology 309. Quantitative Microscopic Approaches are used to Study Neural Circuitry in Schizophrenia and to Determine how Postnatal Ontogenesis may Contribute to the Onset of this Disorder
Catalog Number: 3823
Francine M. Benes (Medical School) 1869

*Neurobiology 310. Neural Coding of Chemosensory Stimuli
Catalog Number: 2408
Rachel I. Wilson (Medical School) 5257

*Neurobiology 311. Cellular and Molecular Studies of Synapse Formation in the Vertebrate Nervous System
Catalog Number: 0081
Joshua R. Sanes 5094

*Neurobiology 312. The Study of Synaptic Competition by Visualizing Synaptic Rearrangements Directly in Living Animals Using Modern Optical Techniques
Catalog Number: 0082
Jeff W. Lichtman 5163

*Neurobiology 313. Molecular Neurobiology of the Biological Clock
Catalog Number: 1758
Charles J. Weitz (Medical School) 1139

*Neurobiology 314. Cellular Mechanism(s) of Axon Guidance
Catalog Number: 1742
Mustafa Sahin (Medical School) 6175

*Neurobiology 315. Neurotrophins and Cerebellar Development
Catalog Number: 0128
Rosalind A. Segal (Medical School) 1564

*Neurobiology 317. Auditory System
Catalog Number: 4979
Lisa V. Goodrich (Medical School) 4771

*Neurobiology 318. Molecular Genetics of Cerebral Cortical Development
Catalog Number: 0825
Christopher A. Walsh (Medical School) 1560

*Neurobiology 319. Neurological Control of Cell Growth and Differentiation
Catalog Number: 2991
Michael E. Greenberg (Medical School) 1400

*Neurobiology 320. Neuroprotection and Neuronal Repair in Neurodegenerative Disease
Catalog Number: 4825
Ole S. Isacson (Medical School) 2077

*Neurobiology 321. Higher Functions in the CNS
Catalog Number: 5387
Margaret S. Livingstone (Medical School) 1064

*Neurobiology 322. Cellular and Molecular Mechanisms in Axon Guidance and Regeneration
Catalog Number: 2873
Zhigang He (Medical School) 3910

*Neurobiology 323. Synaptic Plasticity
Catalog Number: 3209
Florian Engert 4290

*Neurobiology 324. Research in Neuropeptide Gene Regulation
Catalog Number: 4057
Joseph A. Majzoub (Medical School) 1875

*Neurobiology 325. Synaptic Transmissions and Dendritic Processing
Catalog Number: 2065
Wade G. Regehr (Medical School) 1606

*Neurobiology 326. Age-Dependent Mechanisms of Perinatal Brain Injury
Catalog Number: 2469
Frances E. Jensen (Medical School) 3940

*Neurobiology 327. Rotations in Neurosciences
Catalog Number: 5694
Richard T. Born (Medical School) 1787

*Neurobiology 328. Mechanisms of Cell Death in Stroke and Trauma
Catalog Number: 8967
Eng H. Lo (Medical School) 3049

*Neurobiology 329. Molecular and Cell Biology of Alzheimer’s Disease
Catalog Number: 8816
Dennis J. Selkoe (Medical School) 2857

*Neurobiology 330. To Establish Causal Relationships between Gene Expression in the Brain and Motivated Behavior
Catalog Number: 6269
William A. Carlezon (Medical School) 3929

*Neurobiology 331. Molecular Mechanisms that Control Neuronal Differentiation Nerve Growth and Regeneration in the Mammalian Brain and Retina
Catalog Number: 9045
Dong Feng Chen (Medical School) 3930

*Neurobiology 332. Ligand-Gated Ion Channels: Structure and Function
Catalog Number: 1623
Jonathan B. Cohen (Medical School) 1120

*Neurobiology 333. Intercellular Communication
Catalog Number: 2484
David L. Paul (Medical School) 2318

*Neurobiology 334. Sensory Transduction, Tuning and Transmission by Hair Cells and Afferent Neurons of the Inner Ear.
Catalog Number: 1134
Ruth Anne Eatock (Medical School) 5739

*Neurobiology 336. Developmental Cognitive Neuroscience, Focusing Primarily on Memory and Face Processing.
Catalog Number: 2242
Charles A. Nelson (Medical School) 5480

*Neurobiology 337. Neurobiology of the Human Circadian Pacemaker
Catalog Number: 5322
Charles A. Czeisler (Medical School) 7763

*Neurobiology 338. Neural Circuitry of Primate Visual Cortex
Catalog Number: 5634
Richard T. Born (Medical School) 1787

*Neurobiology 339. Mechanisms of Central Synaptic Transmission
Catalog Number: 9322
Vadim Bolshakov (Medical School) 4948

*Neurobiology 340. Neuronal Interactions within the Retina; Processing of Visual Information; Development of the Retina
Catalog Number: 5261
John E. Dowling 3545

*Neurobiology 341. Molecular and Cellular Mechanisms of Cognition and Cognitive Disorders, Particularly the Role of Translational Regulation.
Catalog Number: 8790
Raymond J. Kelleher (Medical School) 5740

*Neurobiology 342. Neurophysiology of Visual Cortex and LGN
Catalog Number: 2778
R. Clay Reid (Medical School) 2957

*Neurobiology 343. Molecular Physiology of Ion Channels
Catalog Number: 1887
Gary I. Yellen (Medical School) 3268

*Neurobiology 345. Molecular Basis of Neuron Glia Interactions
Catalog Number: 4918
Gabriel Corfas (Medical School) 2907

*Neurobiology 346. Visual Processing in Primates
Catalog Number: 0184
John A. Assad (Medical School) 2985

*Neurobiology 347. Alzheimer’s Disease Research
Catalog Number: 6606
Bradley T. Hyman (Medical School) 2952

*Neurobiology 349. Olfactory and Vomeronasal Systems Molecular and Developmental Neurobiology
Catalog Number: 1416
Catherine Dulac 2801

*Neurobiology 350. Molecular Genetics of Neuronal Development
Catalog Number: 2038
Constance L. Cepko (Medical School) 1150

*Neurobiology 351. Neurogenetics of Disease
Catalog Number: 3008
Louis M. Kunkel (Medical School) 1330

*Neurobiology 352. Neural-glial Interaction for the Development and Maintenance of Chronic Pain
Catalog Number: 1264
Ru-Rong Ji (Medical School) 5747

*Neurobiology 353. New Biology Through Physics: Molecular Discoveries with Light
Catalog Number: 3689
David E. Clapham (Medical School) 2987

*Neurobiology 354. Structural Biology of Signaling and Transport Through Biological Membranes
Catalog Number: 9454
Rachelle Gaudet 4413

*Neurobiology 356. Ion Channels in Neural Cell Membranes
Catalog Number: 8368
David P. Corey (Medical School) 1345

*Neurobiology 357. Epigenetic Control of Experience-Dependent Neuronal Circuit Maturation and Plasticity.
Catalog Number: 6674
Michela Fagiolini (Medical School) 5751

*Neurobiology 358. Neurogenetics of Human Disease
Catalog Number: 7616
Xandra O. Breakefield (Medical School) 1428

*Neurobiology 359. Functional Characterization of Neural Circuits - (New Course)
Catalog Number: 23173
Sandeep Robert Datta 6518

*Neurobiology 360. Statistical Modeling and Stochastic Dynamical Systems Analysis of Neurophysiologic Systems
Catalog Number: 8525
Emery N. Brown (Medical School) 1399

*Neurobiology 361. Immunobiology of the Nervous System and its Tumors
Catalog Number: 7282
Lois A. Lampson (Medical School) 2491

*Neurobiology 362. Optical imaging in Alzheimer’s disease
Catalog Number: 5030
Brian Bacskai (Medical School) 6693

*Neurobiology 363. Neural Development and Plasticity
Catalog Number: 7089
Larry I. Benowitz (Medical School) 3150

*Neurobiology 364. Chemical Neuroanatomy of Autonomic Systems
Catalog Number: 1523
Clifford B. Saper (Medical School) 3394

*Neurobiology 365. Behavioral Pharmacology of Stimulant Drugs and Brain Dopamine Systems as they relate to Psychiatric Disorders.
Catalog Number: 8902
S. Barak Caine (Medical School) 5477

*Neurobiology 366. Functional Organization of the Retina
Catalog Number: 7391
Richard H. Masland (Medical School) 4923

*Neurobiology 367. Neo-Cortical Development and Cellular Transplantation
Catalog Number: 4252
Jeffrey D. Macklis (Medical School) 3396

*Neurobiology 368. The Neurobiology of Alzheimer’s Disease and Related Neurodegenerative Disorders
Catalog Number: 5054
Bruce Yankner (Medical School) 1557

*Neurobiology 369. Visual Processing
Catalog Number: 1828
Markus Meister 3007

*Neurobiology 370. Characterization of Genes in Neurodegeneration
Catalog Number: 8336
Rudolph E. Tanzi (Medical School) 2683

*Neurobiology 371. Sensory Neuron Development and Sleep Using Genetics and Live Imaging in Zebrafish.
Catalog Number: 7081
Alexander F. Schier 5238

*Neurobiology 372. Neurotransmitter Control of Ion Channels
Catalog Number: 7104
Bruce P. Bean (Medical School) 1148

*Neurobiology 373. Developmental Studies of the Murine Trigeminal Sensory System
Catalog Number: 7485
Qiufu Ma (Medical School) 3034

*Neurobiology 374. Investigation of the Molecular Basis of Alzheimer’s Disease & Parkinson’s Disease Using Genetic Approaches in Mice
Catalog Number: 9022
Jie Shen (Medical School) 3059

*Neurobiology 375. Mechanisms of Synaptic Transmission & Plasticity
Catalog Number: 0790
Venkatesh N. Murthy 2424

*Neurobiology 376. Genetics of Neuronal Cell Biology
Catalog Number: 2911
Thomas L. Schwarz (Medical School) 3923

*Neurobiology 377. Physiological Studies of Phototransduction and Light Adaptation
Catalog Number: 6897
Clint L. Makino (Medical School) 3946

*Neurobiology 378. Neuronal Mechanisms by which Sensory Information and Memory Guise the Behavior of the Animal.
Catalog Number: 9659
Naoshige Uchida 5745

*Neurobiology 379. Growth Factor Regulation of Neural Development and Oncogenesis
Catalog Number: 7751
Scott L. Pomeroy (Medical School) 3947

*Neurobiology 380. Functional Wiring of the Rabbit Retina, Control of Postnatal Development
Catalog Number: 4965
Elio Raviola (Medical School) 3582

*Neurobiology 381. Mechanisms of Action of Neurotransmitters and Neuromodulators, Specifically Glutamate and Norepinephrine
Catalog Number: 6912
Paul Allen Rosenberg (Medical School) 3949

*Neurobiology 382. The Role of the Hypothalamus and Particularly Melanin Concentrating Hormone in the Regulation of Energy Homeostasis
Catalog Number: 1457
Eleftheria Maratos-Flier (Medical School) 4327

*Neurobiology 383. Role of the Basal Ganglia in Learning and Motivation
Catalog Number: 0492
Emad Eskandar (Medical School) 6176

*Neurobiology 385. The Study of Mammalian Gap Junctions, Inhibitory Neuronal Networks, and Corticothalamic Processing.
Catalog Number: 1296
Carole Landisman (Medical School) 5787

*Neurobiology 386. Changes in the Function, Chemistry and Structure of Sensory Neurons that Contribute to Pain
Catalog Number: 7609
Clifford Woolf (Medical School) 3956

*Neurobiology 389. Molecular Regulation of Neural Tube Development
Catalog Number: 3914
Mary R. Loeken (Medical School) 3151

*Neurobiology 390. Mechanisms of Synapse Regulation
Catalog Number: 9202
Bernardo L. Sabatini (Medical School) 4300

*Neurobiology 392. Synaptic Plasticity in the CNS using Electrophysiological and Calcium Imaging Techniques, as well as Genetically Altered Mouse Strains
Catalog Number: 6750
Chinfei Chen (Medical School) 4437

*Neurobiology 393. Genetic Disorders of Axon Growth and Guidance
Catalog Number: 3085
Elizabeth C. Engle (Medical School) 4312

*Neurobiology 395. Neuron-Glia Interactions During Development and Disease
Catalog Number: 7993
Beth Stevens (Medical School) 6678

*Neurobiology 396. Critical Period Mechanisms of Experience-Dependent Brain Development
Catalog Number: 0142
Takao K. Hensch 5813

*Neurobiology 397. Nervous System Construction and Function
Catalog Number: 0158
Samuel M. Kunes 3486

*Neurobiology 398. CNS and Cancer Gene Therapy
Catalog Number: 4438
Samuel D. Rabkin (Medical School) 4772

*Neurobiology 399. Genetic Engineering in Mice is used to Investigate Neurocircuits Thought to Regulate Metabloism and Behavior.
Catalog Number: 5626
Bradford Barr Lowell (Medical School) 5741

Pathology

Primarily for Graduates

Pathology 209. Tumor Pathophysiology and Transport Phenomena - A Systems Biology Approach
Catalog Number: 5934
Rakesh K. Jain (Medical School)
Half course (fall term). M., 5–7 p.m.
Tumor pathophysiology plays a central role in the growth, metastasis, detection, and treatment of solid tumors. Principles of transport phenomena are applied to develop a quantitative understanding of tumor biology and treatment.
Note: Given in alternate years. Offered jointly with the Medical School as PA 712.0.

Graduate Courses of Reading and Research

*Pathology 302. Molecular Mechanisms of Leukocyte Trafficking
Catalog Number: 2273
Ulrich H. Von Andrian-Werburg (Medical School) 2090

*Pathology 303. Viral Pathogenic and Transformation Mechanisms
Catalog Number: 1644
Peter M. Howley (Medical School) 1076

*Pathology 304. Viral Carcinogenesis
Catalog Number: 1283
Thomas L. Benjamin (Medical School) 4115

*Pathology 307. Endo- and Exocytosis of Membrane Proteins in Kidney Epithelial Cells
Catalog Number: 7151
Dennis Brown (Medical School) 1582

*Pathology 308. Genetic Models of Human Disease
Catalog Number: 1918
Michael C. Carroll (Medical School) 2050

*Pathology 310. Regulation of Vascular Development and Pathology
Catalog Number: 2653
Patricia A. D’Amore (Medical School) 1168

*Pathology 312. Research in Molecular Cytogenetics
Catalog Number: 7347
Cynthia C. Morton (Medical School) 2194

*Pathology 313. Research in Integrin Signaling, Cytoskeleton, and Control of Angiogenesis
Catalog Number: 4139
Donald E. Ingber 2832

*Pathology 314. Molecular Biology of Immune Cell Interactions
Catalog Number: 1156
Timothy A. Springer (Medical School) 6145

*Pathology 315. Epigenomics of Allele-Specific Expression - (New Course)
Catalog Number: 26669
Alexander Gimelbrant 6521

*Pathology 316. Control of Gene Expression in Tumorgenesis and Differentiation
Catalog Number: 3892
Thomas M. Roberts (Medical School) 7729

*Pathology 317. Epithelial:stromal Interactions in the Formation and Progression of Carcinomas - (New Course)
Catalog Number: 93298
Antoine Karnoub 6458

*Pathology 318. Cancer Stem Cell Self-renewal - (New Course)
Catalog Number: 41776
David M. Langenau 6459

*Pathology 321. Intracellular Signaling Mechanisms in Brain Development and Disease
Catalog Number: 8032
Azad Bonni (Medical School) 2923

*Pathology 324. Regulation of T-cell Mediated Immune Response
Catalog Number: 1501
Arlene H. Sharpe (Medical School) 1588

*Pathology 325. Transcriptional Control in Differentiation/Development and Tumorigenesis
Catalog Number: 1509
Yang Shi (Medical School) 3169

*Pathology 327. Genetic Models of Leukemogenesis
Catalog Number: 5534
A. Thomas Look (Medical School) 3771

*Pathology 329. Tissue-Specific Lymphocyte Homing and Diversity
Catalog Number: 7366
James J. Campbell (Medical School) 4438

*Pathology 330. Transcriptional Regulations and Cellular Differentiation
Catalog Number: 5521
T. Keith Blackwell (Medical School) 1826

*Pathology 332. Mechanisms Used by Small DNA Tumor Viruses to Disrupt Controls of Cellular Proliferation
Catalog Number: 0445
Nicholas J. Dyson (Medical School) 1829

*Pathology 333. Models of Human Neurodegenerative Diseases in the Fruit Fly Drosophila
Catalog Number: 4845
Mel B. Feany (Medical School) 4439

*Pathology 334. Characterization of Molecular Targets of Cancer Therapy
Catalog Number: 5744
Daniel A. Haber (Medical School) 1832

*Pathology 335. Molecular Approaches to Cell Immortalization and Transformation
Catalog Number: 2283
William C. Hahn (Medical School) 4317

*Pathology 338. Genetic and Biochemical Analysis of Signal Transduction Pathways
Catalog Number: 2647
Jeffrey E. Settleman (Medical School) 1820

*Pathology 343. Cell Adhesion in Vascular Biology
Catalog Number: 4822
Denisa D. Wagner (Medical School) 2092

*Pathology 350. Topics in Vascular Biology
Catalog Number: 0289
Michael A. Gimbrone (Medical School) 1896

*Pathology 351. Cytoskeleton in Cancer Development and Progression
Catalog Number: 5656
Andrea I. McClatchey (Medical School) 2204

*Pathology 352. Recombination Functions of the BRCA Genes
Catalog Number: 5001
Ralph Scully (Medical School) 4536

*Pathology 353. Cell Cycle Proteins in Development and Cancer
Catalog Number: 1475
Piotr Sicinski (Medical School) 2245

*Pathology 354. Biochemistry of Transmembrane Receptors Interactions
Catalog Number: 9969
Stephen C. Blacklow (Medical School) 1462

*Pathology 359. Signal Transduction Pathways Involved in Cellular Proliferation and Apoptosis
Catalog Number: 2841
Roya Khosravi-Far (Medical School) 2704

*Pathology 360. Biology and Genetics of Human Cancers
Catalog Number: 0188
Matthew L. Meyerson (Medical School) 2421

*Pathology 361. Molecular Mechanisms of Aging and Age Related Diseases
Catalog Number: 6096
David A. Sinclair (Medical School) 2610

*Pathology 362. Gene Targeting, Immunology and Disease
Catalog Number: 5290
Klaus Rajewsky (Medical School) 4330

*Pathology 364. Molecular Genetics of Erythroid Iron Metabolism
Catalog Number: 5354
Mark Daniel Fleming (Medical School) 4955

*Pathology 365. Control of Endothelial Cell Fate and Vascular Development by Fluid Mechanical Forces
Catalog Number: 4860
Guillermo Garcia-Cardena (Medical School) 4956

*Pathology 366. Phagocyte-endothelial Cell Responses in Inflammation
Catalog Number: 4122
Tanya Mayadas (Medical School) 4963

*Pathology 367. Developing Mouse Models for Human Cancers
Catalog Number: 2162
Sandra Orsulic (Medical School) 4964

*Pathology 368. Signaling Pathways in Cancer Cell Biology
Catalog Number: 1919
Alex Toker (Medical School) 4971

*Pathology 369. Molecular Recognition and Protein Engineering
Catalog Number: 8852
J. Keith Joung (Medical School) 5149

*Pathology 370. Cell Cycle Control and Ubiquitin-Mediated Proteolysis
Catalog Number: 1354
J. Wade Harper (Medical School) 4957

*Pathology 371. Biology and Function of Tissue-Specific Stem Cells
Catalog Number: 9993
Amy J. Wagers 5212

*Pathology 372. DNA Damage Responses and Genomic Stability
Catalog Number: 5604
Lee Zou (Medical School) 5258

*Pathology 373. Integration of Cellular Metabolism and Apoptosis
Catalog Number: 8788
Nika Danial (Medical School) 5393

*Pathology 374. Cell Signaling in Innate Immunity
Catalog Number: 9911
Hongbo Luo (Medical School) 5395

*Pathology 375. Mechanisms and Applications of Mammalian RNA Interference
Catalog Number: 2870
Carl D. Novina (Medical School) 5356

*Pathology 376. Mechanism and Regulation of Ribosome Biogenesis
Catalog Number: 3329
Guo-Fu Hu (Medical School) 5402

*Pathology 377. Epigenetic Mechanisms in Mammalian Development
Catalog Number: 5739
Bradley E. Bernstein (Medical School) 5669

*Pathology 378. Epigenetic Regulation in Development and Disease
Catalog Number: 8317
Laurie Jackson-Grusby (Medical School) 5671

*Pathology 379. Mitochondria in Aging and Metabolism
Catalog Number: 7386
Marcia C. Haigis (Medical School) 5734

*Pathology 380. Modeling Ovarian Cancer Pathogenesis and Early Detection
Catalog Number: 8863
Ronny I. Drapkin (Medical School) 5912

*Pathology 381. Ras Signaling and Colon Cancer
Catalog Number: 7281
Kevin M. Haigis (Medical School) 5913

*Pathology 382. Mechanisms of Acute and Chronic Allograft Rejection
Catalog Number: 1744
Richard N. Mitchell (Medical School) 5916

*Pathology 383. Cell Cycle, Ubiquitination and Protein Degradation, Cancer Research
Catalog Number: 9068
Wenyi Wei (Medical School) 5918

*Pathology 384. The Molecular Genetics of Human Cancer
Catalog Number: 3734
Pier Paolo Pandolfi (Medical School) 6177

*Pathology 385. Epigenetic Regulation by Large Non-coding RNA
Catalog Number: 4220
John L. Rinn (Medical School) 6229

*Pathology 386. Hematopoietic Stem Cell Biology and Aging
Catalog Number: 3429
Derrick J. Rossi (Medical School) 6330

*Pathology 387. Kinase Signaling in Cancer
Catalog Number: 8048
Jean J. Zhao (Medical School) 6237

*Pathology 388. Impact of Epigenetics On Cellular Homeostasis
Catalog Number: 5410
Johnathan Whetstine (Medical School) 6244

Pharmacology

Virology

Primarily for Graduates

Virology 201. Virology
Catalog Number: 1190
Sean P.J. Whelan (Medical School), James M. Cunningham (Medical School), David T. Evans (Medical School), and Welkin E. Johnson (Medical School)
Half course (spring term). Tu., Th., 2:30–4.
Literature based reading. Proposal writing. Course covers a broad range of topics: viral genetics, structure/replication, pathogenesis, evolution ("emerging viruses"), chronic infection, latency, innate and adaptive immunity, anti-viral drugs and vaccine strategies.
Note: Offered jointly with the Medical School as MG 723.0.
Prerequisite: Graduate standing and permission required.

Virology 202. Animal Virology: Seminar
Catalog Number: 6025
Michael R. Farzan (Medical School), David T. Evans (Medical School), Frederick C. Wang (Medical School), Priscilla Yang (Medical School), and Xinzhen Yang (Medical School)
Half course (fall term). W., 1:30–4:30.
Students will write, present, and evaluate research proposals in the areas of virus replication, viral pathogenesis and treatment and prevention of viral infections.
Note: Offered jointly with the Medical School as MG 724.0.
Prerequisite: General background in biochemistry and virology.

Graduate Courses of Reading and Research

*Virology 301. Herpes Virus Interaction with the Host Cell
Catalog Number: 7344
David M. Knipe (Medical School) 7089

*Virology 303. Pathogenesis of AIDS and AIDS-related opportunistic infections in nonhuman primate models of simian immunodeficiency virus (SIV) infection
Catalog Number: 6772
Amitinder Kaur (Medical School) 6692

*Virology 304. Molecular Biology of Kaposi’s Sarcoma-Associated Herpes Virus
Catalog Number: 8182
Kenneth M. Kaye (Medical School) 3064

*Virology 305. Transcriptional Regulation of Viral and Mammalian Genes
Catalog Number: 5437
Sean P.J. Whelan (Medical School) 4591

*Virology 306. Structure and Function of Herpes virus DNA Polymerase and the HIV Reverse Transcriptase; Resistance to Antiviral Drugs in Clinical Viral Isolates and Mechanisms of Resistance and Pathogenesis
Catalog Number: 6968
Clyde S. Crumpacker II (Medical School) 1092

*Virology 307. Genetics and Biochemistry of Prokaryotic Transposable Elements and Yeast Meiotic Chromosome Metabolism
Catalog Number: 6097
Nancy Kleckner 4697

*Virology 308. Molecular Genetics of Herpes Virus
Catalog Number: 3000
Donald M. Coen (Medical School) 7617

*Virology 309. Human Oncogenic Viruses
Catalog Number: 4011
Jack L. Strominger 1193

*Virology 310. Cellular Transformation by SV40
Catalog Number: 0221
James A. DeCaprio (Medical School) 1296

*Virology 311. Molecular Biology of Epstein-Barr Infection
Catalog Number: 0513
Frederick C. Wang (Medical School) 1297

*Virology 312. Molecular Biology of Epstein-Barr Virus Infection and Transformation of B-Lymphocytes
Catalog Number: 3483
Elliott D. Kieff (Medical School) 1858

*Virology 313. Molecular Basis for Simian Virus Pathogenesis
Catalog Number: 2528
Ronald C. Desrosiers (Medical School) 1874

*Virology 314 (formerly *Pathology 323). Viral Oncoproteins as Probes to Study the Regulation of Cell Growth and Differentiation
Catalog Number: 6286
Karl Münger (Medical School) 1586

*Virology 315. Mechanisms of Transcriptional Repression in Eukaryotic Cells
Catalog Number: 0462
Yang Shi (Medical School) 3169

*Virology 317. Virology and Immunology of Human Retroviruses
Catalog Number: 0954
Myron Essex (Public Health) 2499

*Virology 318. Persistence and Pathogenesis of Hepatitis C Virus Infection
Catalog Number: 9144
Raymond Taeyong Chung (Medical School) 6178

*Virology 319. Functional Analysis of Tumor Suppression Genes
Catalog Number: 5817
David Morse Livingston (Medical School) 4872

*Virology 320. Pathogenesis of Human Retroviruses
Catalog Number: 1532
Joseph G. Sodroski (Public Health) 1712

*Virology 321. Retroviral DNA Integration
Catalog Number: 6857
Alan N. Engelman (Medical School) 2196

*Virology 322. HIV Molecular Biology and Pathogenesis
Catalog Number: 9023
Dana Gabuzda (Medical School) 1581

*Virology 323. Immunobiology of the Epstein-Barr Virus Receptor; Pathogenesis of EBV and B-cell Tumors
Catalog Number: 0778
Joyce D. Fingeroth (Medical School) 2707

*Virology 324. Leukemogenic Retroviruses
Catalog Number: 5263
James M. Cunningham (Medical School) 2346

*Virology 325. Retroviral Pathogenesis; Host-Virus Interactions Including Virus-Induced Perturbation of the Developing Immune System; the Nature of Protective Anti-Retroviral Immune Responses in Primates
Catalog Number: 8029
Ruth M. Ruprecht (Medical School) 2716

*Virology 326. Pathogenesis and Treatment of Human Retrovirus and Herpesvirus Infection
Catalog Number: 6440
Martin S. Hirsch (Medical School) 2876

*Virology 327. Epstein-Barr virus nuclear proteins in lymphomagensis and the viral lifecycle
Catalog Number: 8083
Eric Christian Johannsen 6264

*Virology 328. Humoral Response to Retroviral Infections in Humans; Identification of Coding Sequence of Human Retroviruses and their Gene Products
Catalog Number: 2513
Tun-Hou Lee (Public Health) 2769

*Virology 329. Cellular Immunology of Persistent Human Virus Infections
Catalog Number: 5417
Bruce Walker (Medical School) 2847

*Virology 330. Critical Readings in Virology
Catalog Number: 5966
David Lopes Cardozo (Medical School) 5995
A series of reading and discussion seminars, each running for a half term (seven weeks). Different topics are covered each term.
Note: Two seminars, which can be taken in different terms, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 617-432-0162 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Virology 331. Polyomavirus JC, the Etiologic Agent of Progressive Multifocal Eukoencephalopathy (PML)
Catalog Number: 9476
Igor J. Koralnik (Medical School) 6179

*Virology 332. Protein Phosphorylation and Gene Expression in Normal and Transformed Cells
Catalog Number: 9093
Raymond L. Erikson 7506

*Virology 333. Antiretroviral Drug Resistance, and Drug Resistant Human Immunodeficiency Virus
Catalog Number: 5526
Daniel R. Kuritzkes (Medical School) 4773

*Virology 334. HIV-1 and Other Viruses
Catalog Number: 3803
Michael R. Farzan (Medical School) 4775

*Virology 336. Genetic Changes in HIV and Hepatitis C Virus
Catalog Number: 8685
Todd Allen (Medical School) 6180

*Virology 337. Humoral and Innate Immune Responses During Viral Infections Focusing on HIV-1 Infection
Catalog Number: 0111
Xinzhen Yang (Medical School) 6182

*Virology 338. Metabolism and Survival Pathways of Epstein-Barr Virus
Catalog Number: 7495
Ellen D. Cahir-McFarland 6268

*Virology 339. Mechanisms of HIV protein degradation, epitope processing and presentation to virus-specific CD8 T cells
Catalog Number: 3999
Sylvie Le Gall 6269

*Virology 347 (formerly *Microbiology 342). Reovirus Structure, Assembly, and Particle Functions in Entry and RNA Synthesis
Catalog Number: 4181
Max L. Nibert (Medical School) 3896

*Virology 348. Immunopathogenesis of HIV-1 and the Development of HIV-1 Vaccine Strategies
Catalog Number: 8409
Dan Hung Barouch (Medical School) 5744

*Virology 349. Imaging Techniques to Study the Behavior of Individual Biological Molecules and Complexes in Vitro and in Live Cells - (New Course)
Catalog Number: 33202
Xiaowei Zhuang 3991 (on leave 2009-10)