Biological Sciences in Public Health

Faculty of the Committee on Higher Degrees in Public Health Sciences

James H. Ware, Frederick Mosteller Professor of Biostatistics (Public Health) (Chair)
Lisa Faye Berkman, Florence Sprague Norman and Laura Smart Norman Professor of Health and Social Behavior and of Epidemiology (Public Health)
Bruce F. Demple, Professor of Toxicology (Public Health)
Thomas O. Fox, Associate Professor of Neuroscience (Medical School)
Laurie H. Glimcher, Professor of Medicine (Medical School) and Irene Heinz Given Professor of Immunology (Public Health)
J. Woodland Hastings, Paul C. Mangelsdorf Professor of Natural Sciences
Nan Laird, Professor of Biostatistics (Public Health)
Carl N. Morris, Professor of Statistics (on leave 2001-02)
Robert D. Putnam, Peter and Isabel Malkin Professor of Public Policy
Dyann F. Wirth, Professor of Tropical Public Health (Public Health)

Faculty of the Subcommittee on the Doctor of Philosopy in Biological Sciences in Public Health

Dyann F. Wirth, Professor of Tropical Public Health (Public Health) (Chair)
Joseph D. Brain, Cecil K. and Phillip Drinker Professor of Environmental Physiology (Public Health)
Raymond L. Erikson, American Cancer Society Professor of Cellular and Developmental Biology
Myron E. Essex, Mary Woodard Lasker Professor of Health Sciences (Public Health)
Thomas O. Fox, Associate Professor of Neuroscience (Medical School)
J. Woodland Hastings, Paul C. Mangelsdorf Professor of Natural Sciences
John B. Little, James Stevens Simmons Professor of Radiobiology (Public Health)
Bjørn R. Olsen, Harvard-Forsyth Professor of Oral Biology and Hersey Professor of Cell Biology (Dental School, Medical School)
Armen H. Tashjian, Jr., Professor of Toxicology, emeritus (Public Health) and Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Walter C. Willett, Professor of Medicine (Medical School) and Frederick John Stare Professor of Epidemiology and Nutrition (Public Health)

Other Faculty Offering Instruction in Biological Sciences in Public Health

Robert B. Banzett, Associate Professor of Medicine and Associate Professor in the Department of Environmental Health (Medical School, Public Health)
Barry R. Bloom, Dean of the Faculty and Professor of Immunology & Infectious Diseases (Public Health)
Harriet A. Burge, Associate Professor of Environmental Microbiology (Public Health)
Barbara Burleigh, Assistant Professor of Immunology & Infectious Diseases (Public Health)
James N. Butler, Gordon McKay Professor of Applied Chemistry, Emeritus
Hannia Campos, Assistant Professor of Nutrition (Public Health)
David Christiani, Professor of Medicine (Medical School)
John R. David, Professor of Medicine (Medical School) and Richard Pearson Strong Professor of Immunology and Infectious Diseases (Public Health)
Timothy E. Ford, Assistant Professor of Environmental Microbiology (Public Health)
Jeffrey J. Fredberg, Professor of Bioengineering and Physiology (Public Health)
Marcia Goldberg, Associate Professor of Medicine (Microbiology and Molecular Genetics) (Medical School)
Beatriz Susana Gonzalez-Flecha, The Mark and Catherine Winkler Assistant Professor of Molecular Biology and Environmental Health (Public Health)
Michael Grusby, Associate Professor of Molecular Immunology (Public Health) and Associate Professor of Medicine (Public Health)
Donald A. Harn, Professor of Tropical Public Health (Public Health)
I-Cheng Ho, Assistant Professor of Medicine (Medical School)
David J. Hunter, Professor of Epidemiology (Public Health)
Phyllis J. Kanki, Professor of Pathobiology (Public Health)
Karl Kelsey, Professor of Occupational Medicine (Public Health) and Professor of Medicine (Medical School)
Lester Kobzik, Associate Professor of Pathology Medical School and Associate Professor in the Department of Environmental Health (Public Health)
Roberto G. Kolter, Professor of Microbiology and Molecular Genetics (Medical School)
Igor Kramnik, Assistant Professor of Immunology (Public Health)
Catherine A. Lee, Silas Arnold Houghton Associate Professor of Microbiology and Molecular Genetics (Medical School)
Tun-Hou Lee, Professor of Virology (Public Health)
Marc Lipsitch, Assistant Professor of Epidemiology (Public Health)
Carl G. Maki, Assistant Professor of Radiobiology (Public Health)
Joseph P. Mizgerd, Assistant Professor of Physiology and Cell Biology (Public Health)
Karl Münger, Associate Professor of Pathology (Medical School)
Mark Perrella, Assistant Professor of Medicine (Medical School) and Assistant Professor in the Division of Biological Sciences (Public Health)
Guy L. Reed III, Associate Professor of Medicine (Medical School) and Associate Professor of Immunology(Public Health)
Eric J. Rubin, Assistant Professor of Immunology and Infectious Diseases (Public Health)
Frank M. Sacks, Professor of Medicine (Medical School) and Professor in the Department of Nutrition (Public Health)
John C. Samuelson, Associate Professor of Tropical Public Health (Public Health) and Clinical Fellow in Pathology (Medical School)
Steven A. Shea, Assistant Professor in the Department of Environmental Health (Public Health) and Assistant Professor of Medicine (Medical School)
Stephanie A. Shore, Associate Professor of Physiology (Public Health)
Joseph G. Sodroski, Professor of Pathology (Medical School) and Professor of Cancer Biology (Public Health)
Ali A. Sultan, Assistant Professor of Immunology and Infectious Diseases (Public Health)
Ning Wang, Assistant Professor of Physiology and Cell Biology (Public Health)
Marianne Wessling-Resnick, Professor of Nutrition (Public Health, Medical School)
Dieter Wolf, Assistant Professor of Toxicology (Public Health)
Xiping Xu, Associate Professor of Occupational Epidemiology (Public Health) and Associate Professor of Medicine (Medical School)
Zhi-Min Yuan, Assistant Professor of Radiobiology (Public Health)

See other courses in the School of Public Health catalog.

Primarily for Graduates

*BPH 205. Introduction to Cancer Biology
Catalog Number: 6234 Enrollment: Limited to 30.
Carl G. Maki (Public Health)
Half course (fall term). Hours to be arranged.
Emphasizes current experimental approaches to studying cancer biology and the process of carcinogenesis.Topics include the biology of cell modification and differentiation, the phenotype of the cancer cell, properties of human and animal cancers, the process of cell transformation, mutagenesis, carcinogen metabolism, and cancer epidemiology.
Prerequisite: College-level course in biology required.

BPH 206. Advanced Respiratory Physiology
Catalog Number: 1049
Stephanie A. Shore (Public Health)
Half course (fall term). M., W., 9–10:20.
Covers a broad range of topics in respiratory physiology including: lung structure, volume and flow mechanics, surfactant function, gas exchange, lung and chest wall interaction. Special topics may include pulmonary circulation, lung endocrine functions, airway physiology and pharmacology. Reviews classic concepts and presents some recent advances.
Note: Offered jointly with the School of Public Health as EH 223ab. Offered jointly with the Medical School as BPH 735.0.
Prerequisite: College-level physiology and EH 205ab or equivalent or signature of instructor indicating suitable background required.

BPH 207. Advanced Topics in Physiology
Catalog Number: 2146
Jeffrey J. Fredberg (Public Health)
Half course (spring term). M., 10:30–12:20, W., 3:30–5:20. EXAM GROUP: 3, 4, 5, 8, 9
Focus on special topics in lung biology. Emphasis is on the fundamental physical basis and quantitative description of chemical, electrical, and mechanical signaling within the cell. Specific topics include passive diffusion, facilitated diffusion, solvent and solvent transport, channels, action potentials, membrane transport, and receptor ligand binding.
Note: Offered jointly with the Medical School as BPH 727.0, and with the School of Public Health as EH 225cd.

BPH 208. Human Physiology
Catalog Number: 3627
Nancy Long Sieber and Stephanie A. Shore (Public Health)
Half course (fall term). M., F., 10:30–12:20.
Introduction to the principles governing function in the human body—course designed to provide a framework in physiology for future public health researchers and professionals who have not taken college level physiology. Emphasis placed on concept of homeostasis and integrative aspects of physiology.
Note: Lectures, laboratories. Two 2-hour sessions each, including 2 laboratory meetings. Offered jointly with the Medical School as BPH 728.0 and with the School of Public Health as EH 205ab.
Prerequisite: College level introductory biology or permission of the instructor is required.

BPH 210. Pathophysiology of Human Disease
Catalog Number: 3078
Lester Kobzik (Public Health)
Half course (spring term). M., F., 1:30–3:20. EXAM GROUP: 6, 7, 8
Surveys common and important human disease problems in the major organ systems. Emphasis on understanding the pathophysiologic basis of typical disease manifestations and the pathogenesis of the disease process at a molecular and cellular level. Relevant public health perspectives on the epidemiology or control of disease are also integrated.
Note: Offered jointly with the Medical School as BPH 729.0, and with the School of Public Health as DBE 208cd.
Prerequisite: College-level physiology, EH 205ab, or equivalent.

*BPH 212. Cellular and Molecular Biology of Parasites
Catalog Number: 0703 Enrollment: Limited to 35.
Barbara Burleigh (Public Health), Ali A. Sultan (Public Health), Members of the department, and Guest Lecturers
Half course (spring term). Hours to be arranged.
Covers aspects of biochemistry, cell and molecular biology of protozoan parasites of man (e.g. malaria, toxoplasma, leishmania, trypanosomes, amebae, giardia, and trichodomonads). Includes discussions on mechanisms of pathogenesis, unique parasite biochemistry and organelles, molecular basis of antigenic variation, and population genetics.
Note: Offered in alternate years. Offered jointly with the Medical School as BPH 721.0 and with the School of Public Health as IMI 216cd (formerly TPH 216cd).
Prerequisite: Suitable course in biochemistry, genetics, or microbiology required.

[BPH 213. Cell Response to Mutagens and Carcinogens]
Catalog Number: 0932
Bruce F. Demple (Public Health)
Half course (spring term). Hours to be arranged.
A seminar course based on emerging research on the molecular effects of mutagenic, carcinogenic, and cytotoxic agents. Particular focus on the cellular mechanisms that preserve biological integrity (e.g., cell cycle checkpoints; DNA repair) or mediate cellular responses to stress (e.g., redox signal transduction; apoptosis pathways). Emphasis on critical analysis of research papers and active class participation. Written assignments in developing relevant research projects (mini-grant proposals).
Note: Expected to be given in 2002–03. Given in alternate years. Offered jointly with the Medical School as BPH 723.0 and the School of Public Health as CCB 250cd. Contact instructor at 432-3462.
Prerequisite: Advanced/graduate courses in biochemistry, cell biology, or genetics.

BPH 215. Principles of Toxicology
Catalog Number: 5366
Dieter Wolf (Public Health) and Donald K. Milton (Public Health)
Half course (fall term). Tu., Th., 1:30–3:20.
Emphasizes mechanisms of injury and clinical consequences following exposures to environmental and occupational chemicals. Examines actions at the molecular, cellular, organ system, and organismal levels. Discusses methods for detecting, evaluating, analyzing, and combating toxic effects.
Note: Offered jointly with the Medical School as BPH 713.0 and with the School of Public Health as CCE 204ab.
Prerequisite: Organic chemistry and mammalian physiology or equivalents required. Required lab.

[*BPH 216. Immunology of Infectious Diseases]
Catalog Number: 6938 Enrollment: Limited to 35.
Donald A. Harn (Public Health)
Half course (spring term). Hours to be arranged.
Covers in detail the interactions of pathogens with the host immune system, from pathogen invasion to pathogenesis. Lecture topics include: the role of secretory immune system; innate immunity mediated through the “collectins”; how pathogens regulate the host immune response; pathogen evasion of immune effect or mechanisms; polarization of CD4+ T helper cell subsets and relationship to disease outcome; co-infection with HIV and other pathogens; mechanims of immunopathogenesis; and development of vaccines.Viral, bacterial and parasitic pathogens are covered in the course.
Note: Expected to be given in 2002–03. Offered in alternate years. Offered jointly with the HMS as BPH724.0 and the School of Public Health as IMI208cd. Each lecture requires reading severalrelevant papers and completion of a problem set.
Prerequisite: Course in immunology required.

*BPH 219. Biological Sciences Seminars
Catalog Number: 1152
Michael Grusby (Public Health) and I-Cheng Ho (Medical School)
Half course (fall term). Tu., Th., 8:30–10:20 a.m. EXAM GROUP: 10, 11, 12
Faculty participating in the Biology and Public Health degree program present seminars on their current research in the biological sciences and direct a student discussion of the logic and experimental design of this research. Topics include chemical and viral carcinogenesis, DNA damage and repair, immunology, molecular biology, metabolism, cardiovascular disease, parisitology, and how these areas apply to public health issues.
Note: Required for first-year students in the BPH program. Offered jointly with the School of Public Health as DBS 205ab.

BPH 222. The Science of Human Nutrition
Catalog Number: 0216
Frank M. Sacks, Clifford Lo (Medical School) and members of the Faculty
Half course (spring term). Tu., Th., 1:30–3:20.
Reviews the biochemistry of carbohydrates, fats, proteins, vitamins, and minerals in the context of human disease. Particular emphasis given to current knowledge of the mechanisms that may explain the role of diet in the causation and/or prevention of ischemic heart disease, diabetes, obesity, hypertension, and cancer. Recommended dietary intakes of selected nutrients are discussed in order to understand their limitations.
Note: NUT 201ab is strongly recommended; prior familiarity with nutrition and the health sciences is expected, as is a basic knowledge of biochemistry and human physiology. Offered jointly with the Medical School as BPH 733.0, and with the School of Public Health as NUT 202cd.

Graduate Courses of Reading and Research

*BPH 300r. Laboratory Rotations
Catalog Number: 8441
Dyann F. Wirth (Public Health) 2492 and Marianne Wessling-Resnick (Public Health, Medical School) 1315 (spring term only)
Half course (fall term; repeated spring term). Hours to be arranged.
Members of the Division of Biological Sciences offer hands-on experimental methods of research in the biological sciences.
Note: Offered jointly with the School of Public Health as DBS 300ab, DBS 300cd.

*BPH 302. Molecular Regulation of Thrombosis
Catalog Number: 2731
Guy L. Reed III 1615

*BPH 304. Study of Workplace Mutagen and Carcinogen Exposure
Catalog Number: 2734
Karl Kelsey (Public Health, Medical School) 2316

*BPH 306. Circadian and Sleep Physiology and Disorders
Catalog Number: 2730
Steven A. Shea (Public Health, Medical School) 1309

*BPH 307. Cellular Defenses Against Oxygen Radical Damage
Catalog Number: 2758
Bruce F. Demple (Public Health) 7853

*BPH 311. Molecular Mechanisms of Control of the Biosynthesis, Secretion, and Action of Polypeptide Hormones
Catalog Number: 2757
Armen H. Tashjian, Jr. (Public Health, Medical School) 2071

*BPH 312. Regulation of the Cellular Uptake of Macromolecular Nutrients
Catalog Number: 2736
Marianne Wessling-Resnick (Public Health, Medical School) 1315

*BPH 313. Mechanisms of Drug Resistance in Entamoeba histolytica
Catalog Number: 2681
John C. Samuelson (Public Health, Medical School) 1618

*BPH 315. Molecular Genetic Analysis of Gene Expression and Drug Resistance in Parasitic Protozoan, Including Leishmania and Malaria
Catalog Number: 2756
Dyann F. Wirth (Public Health) 2492

*BPH 316. Immunology and Molecular Biology of Schistosoma mansoni
Catalog Number: 2737
Donald A. Harn (Public Health) 2051

*BPH 317. Gene-Environment Interactions in Human Lipoprotein Metabolism
Catalog Number: 2541
Hannia Campos (Public Health) 2710

*BPH 319. Signaling Mechanisms of Peptide Hormones, Genetic and Molecular Basis of Obesity and Diabetes
Catalog Number: 8425
Gokhan S. Hotamisligil (Public Health) 2725

*BPH 321. Mechanical Mechanisms of Cytoskeleton and its Regulatory Role in Cell Growth and Migration
Catalog Number: 5552
Ning Wang (Public Health) 2737

*BPH 322. Study of Epidemiologic and Biological Characteristics of HIV Viruses in Africa
Catalog Number: 4523
Phyllis J. Kanki (Public Health) 2270

*BPH 323. Human Lipoprotein Metabolism: Biochemistry and Metabolic Modeling
Catalog Number: 5530
Frank M. Sacks 2276

*BPH 324. Protein Phosphorylation and Gene Expression in Normal and Transformed Cells
Catalog Number: 5915
Raymond L. Erikson 7506

*BPH 325. Assessment of the Impact of Workplace Pollutants on Health
Catalog Number: 7448
David Christiani (Public Health, Medical School) 1514

*BPH 330. Advanced Topics in Biological Sciences in Public Health
Catalog Number: 3976
Marianne Wessling-Resnick (Public Health, Medical School) 1315
A series of discussion and seminars each running for a half semester (7-8 weeks). Two seminars, which can be taken in different semesters, are required for half course credit.

*BPH 331. Perception of Afferent Information from the Respiratory System
Catalog Number: 3655
Robert B. Banzett (Medical School, Public Health) 1310

*BPH 332. Function and Structure of Pulmonary and Hepatic Macrophages
Catalog Number: 7331
Joseph D. Brain (Public Health) 2520

*BPH 333. Nature, Prevalence, Health Effects, and Control of Airborne Biological Agents
Catalog Number: 1556
Harriet A. Burge (Public Health) 2761

*BPH 334. Molecular Basis of Host Cell Invasion, Signaling and Differentiation by the Human Pathogen, Trypanosoma cruzi
Catalog Number: 2409
Barbara Burleigh (Public Health) 2763

*BPH 335. The Biology of Cytokines and the Control of Parasitic Infections
Catalog Number: 9204
John R. David (Public Health, Medical School) 3592

*BPH 336. Study of Human and Primate T-lymphotrophic Retroviruses Including Agents that Cause AIDS
Catalog Number: 3248
Myron E. Essex (Public Health) 2499

*BPH 337. Environmental Pollution, Waterborne Disease, Pathogen Survival
Catalog Number: 5110
Timothy E. Ford (Public Health) 1525

*BPH 338. Sexual Differentiation of the Brain: Hormonal and Genetic Determinants
Catalog Number: 4954
Thomas O. Fox (Medical School) 4542

*BPH 339. Mechanical Basis of Airway and Lung Parenchymal Function
Catalog Number: 6572
Jeffrey J. Fredberg (Public Health) 1303

*BPH 340. Genetic Regulation of Immune Response
Catalog Number: 3323
Laurie H. Glimcher (Public Health, Medical School) 1362

*BPH 341. Pathways of Oxidant-dependent Promotion of Cell Growth in Lung Epithelial Cells
Catalog Number: 9308
Beatriz Susana Gonzalez-Flecha (Public Health) 2715

*BPH 342. In Vivo Models of Immune Deficiency by Homologous Recombination in ES Cells
Catalog Number: 2309
Michael Grusby (Public Health, Medical School) 1987

*BPH 343. Molecular Mechanism of Cellular Circadian Regulation
Catalog Number: 7740
J. Woodland Hastings 1311

*BPH 344. Differentiation and Activation of Helper T Cells
Catalog Number: 2319
I-Cheng Ho (Medical School) 2764

*BPH 345. Lung Macrophage Differentiation and Function
Catalog Number: 1495
Lester Kobzik (Medical School, Public Health) 1313

*BPH 346. Genetic Dissection of Mechanisms of Host Susceptibility to Tuberculosis
Catalog Number: 1041
Igor Kramnik (Public Health) 2768

*BPH 347. Bacterial Pathogenesis, Virulence Gene Regulation, Salmonella Invasion
Catalog Number: 0567
Catherine A. Lee (Medical School) 3259

*BPH 348. Human and Related Primate Retroviruses
Catalog Number: 3024
Tun-Hou Lee (Public Health) 2769

*BPH 350. Radiation Mutagenesis and Cardinogenesis; Genetic Instability
Catalog Number: 9227
John B. Little (Public Health) 1427

*BPH 351. Stability and Ubiquitination of Cell Cycle Regulatory Proteins
Catalog Number: 4657
Carl G. Maki (Public Health) 2773

*BPH 352. Regulation of Acute Inflammatory Responses by Signaling Molecules
Catalog Number: 5578
Joseph P. Mizgerd (Public Health) 2787

*BPH 353. Human Papillomaviruses (HPV’s): the Cause of Hyperplastic Skin-leisions
Catalog Number: 6469
Karl Münger (Medical School) 1586

*BPH 354. Molecular Studies of Skeletal and Vascular Morphogenesis
Catalog Number: 8067
Bjørn R. Olsen (Dental School, Medical School) 1164

*BPH 355. Cytokine Regulation of Vasoactive Mediators in the Pathogenesis of Septic Shock
Catalog Number: 9398
Mark Perrella (Public Health, Medical School) 2774

*BPH 357. Physiological and Pharmacological Aspects of Bronchoconstriction.
Catalog Number: 5047
Stephanie A. Shore (Public Health) 1304

*BPH 358. Human Immunodeficiency Virus Envelope Glycoproteins and Vaccine Development
Catalog Number: 0241
Joseph G. Sodroski (Medical School, Public Health) 1712

*BPH 359. Relations of Dietary Factors to the Occurrence of Human Disease
Catalog Number: 8215
Walter C. Willett (Public Health, Medical School) 1805

*BPH 360. DNA Replication and Control of Normal and Abnormal Cell Growth
Catalog Number: 1395
Dieter Wolf (Public Health) 2781

*BPH 361. Genetic Dissection of Complex Diseases
Catalog Number: 1537
Xiping Xu (Public Health, Medical School) 2785

*BPH 362. Delineation of Biochemical and Molecular Basis of Stress Induced Responses
Catalog Number: 4140
Zhi-Min Yuan (Public Health) 9265

*BPH 363. Inherited Susceptibility to Cancer and other Diseases
Catalog Number: 9066
David J. Hunter (Public Health) 3844

*BPH 364. Molecular Biology of Bacterial Interactions; Peptide Production and Release; Growth Phase Regulation of Gene Expression
Catalog Number: 6936
Roberto G. Kolter (Medical School) 7727

*BPH 365. Virulence Factors of Mycrobacteria; Acquisition of Virulence Determinants of Vibrio Cholerae; Generalized Mutagenesis Systems for Bacteria
Catalog Number: 5044
Eric J. Rubin (Public Health) 4084

*BPH 366. Theoretical, Statistical, and Experimental Approaches to Population Biology and the Epidemiology of Infectious Deseases
Catalog Number: 7822
Marc Lipsitch (Public Health) 4097

*BPH 367. Biochemistry and Molecular Pathogenesis of Parasites
Catalog Number: 8906
Ali A. Sultan (Public Health) 3845

*BPH 368. Host-pathogen Interactions of Shigella
Catalog Number: 6995
Marcia Goldberg (Medical School) 3783