Medical Sciences

Faculty of the Committee on Higher Degrees in Medical Sciences

Thomas M. Roberts, Professor of Pathology (Medical School) (Chair)
Nancy Andrews, Associate Professor of Pediatrics (Medical School)
Constance L. Cepko, Professor of Genetics (Medical School)
Jonathan B. Cohen, Professor of Neurobiology (Medical School)
R. John Collier, Maude and Lillian Presley Professor of Microbiology and Molecular Genetics (Medical School)
Raymond L. Erikson, American Cancer Society Professor of Cellular and Developmental Biology
Thomas O. Fox, Associate Professor of Neuroscience (Medical School) (ex officio)
Edward E. Harlow, Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Stephen C. Harrison, Higgins Professor of Biochemistry and Molecular Biology
Peter M. Howley, George Fabyan Professor of Comparative Pathology (Medical School) (ex officio)
Dennis L. Kasper, William Ellery Channing Professor of Medicine (Medical School) (ex officio)
Elliott D. Kieff, Harriet Ryan Albee Professor of Medicine and Professor of Microbiology and Molecular Genetics (Medical School)
Philip Leder, John Emory Andrus Professor of Genetics (Medical School)
Hidde Ploegh, Mallinckrodt Professor of Immunopathology and Professor of Pathology (Medical School)
Joan V. Ruderman, Marion V. Nelson Professor of Cell Biology (Medical School)

Other Faculty Offering Instruction in the Division of Medical Sciences

Chester Alper, Professor of Pediatrics (Medical School)
Frederick W. Alt, Charles A. Janeway Professor of Genetics (Medical School)
Paul J. Anderson, Associate Professor of Medicine (Medical School)
John A. Assad, Assistant Professor of Neurobiology (Medical School)
Hugh Auchincloss, Professor of Surgery (Medical School)
Dennis A. Ausiello, Jackson Professor of Clinical Medicine (Medical School)
K. Frank Austen, Theodore Bevier Bayles Professor of Medicine (Medical School)
Frederick Ausubel, Professor of Genetics (Medical School)
Hamid Band, Associate Professor of Medicine (Medical School)
Robert B. Banzett, Associate Professor of Medicine and Associate Professor in the Department of Environmental Health (Medical School, Public Health)
Bruce P. Bean, Professor of Neurobiology (Medical School)
Jonathan R. Beckwith, American Cancer Society Professor of Microbiology and Molecular Genetics (Medical School)
Alan H. Beggs, Associate Professor of Pediatrics (Medical School)
David R. Beier, Associate Professor of Medicine (Medical School)
Welcome W. Bender, Harold T. White Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Gilles A. Benichou, Assistant Professor of Opthalmology (Medical School)
Thomas L. Benjamin, Professor of Pathology (Medical School)
Larry I. Benowitz, Associate Professor of Neurosurgery (Medical School)
Jack Bergman, Associate Professor of Psychobiology (Medical School)
Andre Bernards, Associate Professor of Medicine (Medical School)
Merton Bernfield, Clement A. Smith Professor of Pediatrics and Professor of Anatomy and Biology (Medical School)
Marla J. Berry, Associate Professor of Medicine (Medical School)
Joyce E. Bischoff, Assistant Professor of Cellular and Molecular Physiology (Surgery) (Medical School)
Stephen C. Blacklow, Assistant Professor of Pathology (Medical School)
T. Keith Blackwell, Assistant Professor of Pathology (Medical School)
John Blenis, Professor of Cell Biology (Medical School)
Kurt J. Bloch, Professor of Medicine (Medical School)
Richard S. Blumberg, Associate Professor of Medicine (Medical School)
Azad Bonni, Assistant Professor of Pathology (Medical School)
Richard T. Born, Assistant Professor of Neurobiology (Medical School)
Joseph D. Brain, Cecil K. and Phillip Drinker Professor of Environmental Physiology (Public Health)
Xandra O. Breakefield, Professor of Neurology (Medical School)
Michael B. Brenner, K. Frank Austen Professor of Medicine (Medical School)
Dennis Brown, Associate Professor of Pathology (Medical School)
Robert H. Brown, Professor of Neurology (Medical School)
Joan S. Brugge, Professor of Cell Biology (Medical School)
Linda D. Buck, Associate Professor of Neurobiology (Medical School)
Kathleen M. Buckley, Associate Professor of Neurobiology (Medical School)
Steven J. Burakoff, Professor of Pediatrics (Medical School)
Stephen Buratowski, Associate Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Rami Burstein, Associate Professor of Anaethesia (Medical School)
Stephen Calderwood, Associate Professor of Medicine (Medical School)
Hannia Campos, Assistant Professor of Nutrition (Public Health)
Stephen C. Cannon, Associate Professor of Neurology (Medical School)
Lewis C. Cantley, Professor of Cell Biology (Medical School)
Harvey Cantor, Professor of Pathology (Medical School)
Charles B. Carpenter, Professor of Medicine (Medical School)
Michael C. Carroll, Professor of Pediatrics (Medical School)
Lan Bo Chen, Professor of Pathology (Medical School)
George M. Church, Professor of Genetics (Medical School)
David E. Clapham, Professor of Neurobiology (Medical School)
Donald M. Coen, Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Tucker Collins, Professor of Pathology (Medical School)
David P. Corey, Professor of Neurobiology (Medical School)
Gabriel Corfas, Assistant Professor of Neurology (Medical School)
Clyde S. Crumpacker II, Professor of Medicine (Medical School)
James M. Cunningham, Associate Professor of Medicine (Medical School)
Patricia A. D’Amore, Professor of Opthalmology and Pathology (Medical School)
Alan D. D’Andrea, Associate Professor of Pediatrics (Medical School)
John R. David, Professor of Medicine (Medical School) and Richard Pearson Strong Professor of Immunology and Infectious Diseases (Public Health)
Charles R. Dearolf, Associate Professor of Pediatrics (Genetics) (Medical School)
James A. DeCaprio, Associate Professor of Medicine (Medical School)
Ronald A. DePinho, Professor of Medicine (Medical School)
Ronald C. Desrosiers, Professor of Microbiology and Molecular Genetics (Medical School)
William F. Dietrich, Assistant Professor of Genetics (Medical School)
Patricia K. Donahoe, Marshall K. Bartlett Professor of Surgery (Medical School)
Martin E. Dorf, Professor of Pathology (Medical School)
John E. Dowling, Harvard College Professor and Llura Gund Professor of Neurosciences
Ursula C. Dräger, Associate Professor of Psychiatry (Medical School)
Glenn Dranoff, Assistant Professor of Medicine (Medical School)
Thaddeus P. Dryja, Jr., David Glendenning Cogan Professor of Ophthalmology (Medical School)
Anindya Dutta, Associate Professor of Pathology (Medical School)
Ann M. Dvorak, Professor of Pathology (Medical School)
Susan M. Dymecki, Assistant Professor of Genetics (Medical School)
Nicholas J. Dyson, Associate Professor of Medicine (Medical School)
Michael J. Eck, Assistant Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Elaine A. Elion, Associate Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Thomas E. Ellenberger, Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Joel K. Elmquist, Assistant Professor of Neurology (Medical School)
Alan M. Engelman, Assistant Professor of Pathology (Medical School)
Tamar L. Enoch, Associate Professor of Genetics (Medical School)
Raymond L. Erikson, American Cancer Society Professor of Cellular and Developmental Biology
Myron E. Essex, Mary Woodard Lasker Professor of Health Sciences (Public Health)
R. Alan Ezekowitz, Charles Wilder Professor of Pediatrics (Medical School)
Daniel D. Federman, Carl W. Walter Professor of Medicine and Medical Education (Medical School)
Joyce D. Fingeroth, Assistant Professor of Medicine (Medical School)
Daniel Finley, Associate Professor of Cell Biology (Medical School)
David E. Fisher, Associate Professor of Pediatrics (Medical School)
Mark C. Fishman, Professor of Medicine (Medical School)
John G. Flanagan, Associate Professor of Cell Biology (Medical School)
William C. Forrester, Assistant Professor of Pathology (Medical School)
Dan G. Fraenkel, Professor of Microbiology and Molecular Genetics (Medical School)
Christin A. Frederick, Assistant Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Edwin J. Furshpan, Robert Henry Pfeiffer Professor of Neurobiology (Medical School)
Dana Gabuzda, Associate Professor of Neurology (Medical School)
Raif S. Geha, Prince Turki Bin Abdul Aziz Al-Saud Professor of Pediatrics (Medical School)
Lee Gehrke, Professor of Health Sciences and Technology and MMG (Medical School)
Katia Georgopoulos, Associate Professor of Dermatology (Medical School)
John Gergely, Associate Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Grace Gill, Assistant Professor of Pathology (Medical School)
D. Gary Gilliland, Associate Professor of Medicine (Medical School)
Michael A. Gimbrone, Elsie T. Friendman Professor of Pathology (Medical School)
Ilene K. Gipson, Professor of Ophthalmology (Medical School)
Laurie H. Glimcher, Professor of Medicine (Medical School) and Irene Heinz Given Professor of Immunology (Public Health)
David E. Golan, Associate Professor of Medicine and Associate Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Alfred L. Goldberg, Professor of Cell Biology (Medical School)
Irving H. Goldberg, Otto Krayer Professor of Pharmacology (Medical School)
Anne E. Goldfeld, Assistant Professor of Medicine (Medical School)
Peter Goldman, Maxwell Finland Professor of Biological Chemistry and Molecular Pharmacology (Medical School) and Professor of Health Sciences in Nutrition (Public Health)
Beatriz Susana Gonzalez-Flecha, The Mark and Catherine Winkler Assistant Professor of Molecular Biology and Environmental Health (Public Health)
Daniel A. Goodenough, Takeda Professor of Cell Biology (Medical School)
Howard M. Goodman, Professor of Genetics (Medical School)
Heinrich G.J. Gottlinger, Associate Professor of Pathology (Medical School)
Howard Green, George Higginson Professor of Cellular and Molecular Physiology (Medical School)
Jeremy Green, Assistant Professor of Genetics (Medical School)
Michael E. Greenberg, Professor of Neurology (Medical School)
Michael Grusby, Associate Professor of Molecular Immunology (Public Health)and Associate Professor of Medicine (Medical School)
James Gusella, Bullard Professor of Neurogenetics (Medical School)
Daniel A. Haber, Associate Professor of Medicine (Medical School)
David Hafler, Jack, Sadie, and David Breakstone Professor of Neurology (NSCI) (Medical School)
Iswar K. Hariharan, Associate Professor of Medicine (Medical School)
Edward E. Harlow, Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Donald A. Harn, Professor of Medicine (Public Health)
Anne C. Hart, Assistant Professor of Pathology (Medical School)
Elizabeth D. Hay, Louise Foote Pfeiffer Professor of Embryology (Medical School)
Wilson C. Hayes, Maurice Edmond Mueller Professor of Biomechanics (Medical School)
Xi He, Assistant Professor of Neurology (Medical School)
Martin E. Hemler, Professor of Pathology (Medical School)
Darren E. Higgins, Assistant Professor of Microbiology & Molecular Genetics (Medical School)
Philip W. Hinds, Assistant Professor of Pathology (Medical School)
Martin S. Hirsch, Professor of Medicine (Medical School) and Professor in the Department of Cancer Biology (Public Health)
Ann Hochschild, Professor of Microbiology and Molecular Genetics (Medical School)
James M. Hogle, Edward S. Harkness Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Victor Wee Hsu, Assistant Professor of Medicine (Medical School)
David H. Hubel, Research Professor of Neurobiology (Medical School)
Bradley T. Hyman, Professor of Neurology (Medical School)
John J. Iacomini, Assistant Professor of Surgery (Medical School)
Donald E. Ingber, Professor of Pathology (Medical School)
Luisa Iruela-Arispe, Assistant Professor of Pathology (Medical School)
Ole S. Isacson, Associate Professor of Neurology (Medical School)
Kurt I. Isselbacher, Mallinckrodt Professor of Medicine (Medical School)
Rakesh K. Jain, A. Werk Cook Professor of Radiation Oncology (Medical School)
Farish A. Jenkins, Jr., Alexander Agassiz Professor of Zoology in the Museum of Comparative Zoology and Professor of Biology, and Professor of Anatomy in the Harvard-MIT Division of Health Sciences and Technology (Medical School)
Robert P. Johnson, Associate Professor of Medicine (Medical School)
Jae Ung Jung, Associate Professor of Microbiology and Molecular Genetics (Medical School)
C. Ronald Kahn, Mary K. Iacocca Professor of Medicine (Medical School)
Lee M. Kaplan, Assistant Professor of Medicine (Medical School)
Morris J. Karnovsky, Shattuck Professor of Pathological Anatomy (Medical School)
Howard R. Katz, Associate Professor of Medicine (Medical School)
Kenneth M. Kaye, Assistant Professor of Medicine (Medical School)
Andrius Kazlauskas, Associate Professor of Opthalmology (Medical School)
Vicki R. Kelley, Associate Professor of Medicine (Medical School)
Samuel Kennedy, Lecturer on Cell Biology (Medical School)
Roya Khosravi-Far, Assistant Professor of Pathology (Medical School)
Kwang-Soo Kim, Associate Professor of Psychiatry (Medical School)
Jean-Pierre Kinet, Professor of Pathology (Medical School)
Robert E. Kingston, Professor of Genetics (Medical School)
Tomas Kirchhausen, Professor of Cell Biology (Medical School)
Marc W. Kirschner, Carl Walter Professor of Medicine and Cell Biology (Medical School)
Michael Klagsbrun, Professor of Surgery (Medical School)
Nancy Kleckner, Herchel Smith Professor of Molecular Biology
David M. Knipe, Higgins Professor of Microbiology and Molecular Genetics (Medical School)
Roberto G. Kolter, Professor of Microbiology and Molecular Genetics (Medical School)
Bruce R. Korf, Associate Professor of Neurology (Medical School)
Walter J. Koroshetz, Associate Professor of Medicine and Assistant Professor of Neurology (Medical School)
Stanley J. Korsmeyer, Sidney Farber Professor of Pathology (Medical School)
Kenneth S. Kosik, Professor of Neurology (Medical School)
Edward A. Kravitz, George Packer Berry Professor of Neurobiology (Medical School)
Jordan A. Kreidberg, Assistant Professor of Pediatrics (Medical School)
Vijay K. Kuchroo, Associate Professor of Neurology (Medical School)
Louis M. Kunkel, Professor of Genetics and Professor of Pediatrics (Medical School)
David J. Kwiatkowski, Associate Professor of Medicine (Medical School)
Lois A. Lampson, Associate Professor of Neuroscience (Medical School)
Peter T. Lansbury, Associate Professor of Neurology (Medical School)
Andrew B. Lassar, Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Claude P. Lechene, Visiting Professor of Medicine (Medical School)
Catherine A. Lee, Silas Arnold Houghton Associate Professor of Microbiology and Molecular Genetics (Medical School)
Jeannie T. Lee, Assistant Professor of Genetics (Medical School)
Tun-Hou Lee, Associate Professor of Virology (Medical School)
Marjorie B. Lees, Professor of Biochemistry, Emerita (Medical School)
Norman Letvin, Professor of Medicine (Medical School)
Harvey Louis Levy, Associate Professor of Pediatrics (Medical School)
Rong Li, Assistant Professor of Cell Biology (Medical School)
Towia A. Libermann, Professor of Medicine (Medical School)
Andrew H. Lichtman, Associate Professor of Pathology (Medical School)
Judy Lieberman, Associate Professor of Pediatrics (Medical School)
Edmund C. C. Lin, Professor of Microbiology and Molecular Genetics (Medical School)
Stuart A. Lipton, Associate Professor of Surgery (Neuroscience) (Medical School)
John B. Little, James Stevens Simmons Professor of Radiobiology (Public Health)
David M. Livingston, Emil Frei Professor of Medicine (Medical School)
Margaret S. Livingstone, Professor of Neurobiology (Medical School)
Clifford Lo, Assistant Professor of Pediatrics (Medical School)
Eng H. Lo, Associate Professor of Radiology (Medical School)
Mary R. Loeken, Assistant Professor of Medicine (Medical School)
A. Thomas Look, Professor of Pediatrics (Medical School)
David N. Louis, Associate Professor of Pathology (Medical School)
Kun Ping Lu, Assistant Professor of Medicine (Medical School)
Francis W. Luscinskas, Associate Professor of Pathology (Medical School)
Andrew D. Luster, Associate Professor of Medicine (Medical School)
Samuel E. Lux IV, Robert A. Stranahan Professor of Pediatrics (Medical School)
Qiufu Ma, Assistant Professor of Neurobiology (Medical School) (Medical School)
Richard L. Maas, Associate Professor of Medicine (Medical School)
Jeffrey D. Macklis, Associate Professor of Neurology (Medical School)
Joseph A. Majzoub, Associate Professor of Pediatrics and Medicine (Medical School)
Jarema Malicki, Assistant Professor of Ophthalmology (Medical School)
Richard H. Masland, Charles Anthony Pappas Professor of Neuroscience (Medical School)
Bruce J. Mayer, Assistant Professor of Microbiology and Molecular Genetics (Medical School)
Peter McCaffery, Assistant Professor of Psychiatry (Medical School)
Andrea I. McClatchey, Assistant Professor of Pathology (Medical School)
Frank D. McKeon, Professor of Cell Biology (Medical School)
Markus Meister, Jeff C. Tarr Professor of Molecular and Cellular Biology
John J. Mekalanos, Higgins Professor of Microbiology and Molecular Genetics (Medical School)
Mark Mercola, Associate Professor of Cell Biology (Medical School)
Matthew L. Meyerson, Assistant Professor of Pathology (Medical School)
Alan M. Michelson, Associate Professor of Medicine (Medical School)
Keith W. Miller, Mallinckrodt Professor of Pharmacology (Medical School)
Timothy J. Mitchison, Hasib Sabbagh Professor of Cell Biology (Medical School)
Joseph P. Mizgerd, Assistant Professor of Physiology and Cell Biology (Public Health)
Danesh Moazed, Assistant Professor of Cell Biology (Medical School)
Donald K. Morisato, Assistant Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
James Morris, Junior Fellow of the Society of Fellows (Medical School)
William H. Morse, Professor of Psychobiology (Medical School)
Cynthia C. Morton, Professor of Pathology and William Lambert Richards Professor of Obstetrics, Gynecology, and Reproductive Biology (Medical School)
Edmund A. Mroz, Jr., Associate Professor of Physiology (Medical School)
Richard C. Mulligan, Mallinckrodt Professor of Genetics (Medical School)
Karl Münger, Associate Professor of Pathology (Medical School)
Lee M. Nadler, Professor of Medicine (Medical School)
Cathryn R. Nagler-Anderson, Assistant Professor of Pediatrics (Medical School)
Benjamin Neel, Professor of Medicine (Medical School)
Ellis J. Neufeld, Associate Professor of Pediatrics (Medical School)
Rachael L. Neve, Associate Professor of Genetics (Medical School)
Anne Nicholson-Weller, Associate Professor of Medicine (Medical School)
Marjorie A. Oettinger, Associate Professor of Genetics (Medical School)
Bjørn R. Olsen, Harvard-Forsyth Professor of Oral Biology and Hersey Professor of Cell Biology (Dental School, Medical School)
Santa Jeremy Ono, Associate Professor of Ophthamology (Medical School)
Stuart H. Orkin, Leland Fikes Professor of Pediatric Medicine (Medical School)
Christina M. Parker, Assistant Professor of Medicine (Medical School)
Jeffrey D. Parvin, Assistant Professor of Pathology (Medical School)
David L. Paul, Professor of Neurobiology (Medical School)
Joseph D. Paulauskis, Associate Professor of Molecular Biology (Public Health)
Henry P. Paulus, Associate Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Michael Pazin, Assistant Professor of Dermatology (Medical School)
David Pellman, Assistant Professor of Pediatrics (Medical School)
Lizabeth A. Perkins, Assistant Professor of Surgery (Genetics) (Medical School)
Norbert Perrimon, Professor of Genetics (Medical School)
Shiv S. Pillai, Associate Professor of Medicine (Medical School)
David D. Potter, Robert Winthrop Professor of Neurobiology (Medical School)
Robert R. Rando, Gustavus Adolphus Pfeiffer Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Anjana Rao, Professor of Pathology (Medical School)
Tom Rapoport, Professor of Cell Biology (Medical School)
Gary A. Rathbun, Assistant Professor of Pediatrics (Medical School)
Elio Raviola, Bullard Professor of Neurobiology and Professor of Ophthalmology (Medical School)
Guy L. Reed III, Associate Professor of Medicine (Medical School) and Associate Professor of Immunology(Public Health)
Robin Reed, Professor of Cell Biology (Medical School)
Wade G. Regehr, Associate Professor of Neurobiology (Medical School)
R. Clay Reid, Associate Professor of Neurobiology (Medical School)
Ellis L. Reinherz, Professor of Medicine (Medical School)
Steven M. Reppert, Professor of Pediatrics (Medical School)
Charles C. Richardson, Edward S. Wood Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Barrett J. Rollins, Associate Professor of Medicine (Medical School)
Fred S. Rosen, James L. Gamble Professor of Pediatrics (Medical School)
Michael Rosenblatt, Ebert Professor of Molecular Medicine (Medical School)
Nadia Rosenthal, Associate Professor of Medicine (Medical School)
Andre Rosowsky, Associate Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Robert H. Rubin, Gordon and Marjorie Osborn Professor of Health Sciences and Technology, Professor of Medicine (Medical School)
Joan V. Ruderman, Marion V. Nelson Professor of Cell Biology (Medical School)
Christopher E. Rudd, Associate Professor of Pathology (Medical School)
Ruth M. Ruprecht, Professor of Medicine (Medical School)
Mary E. Russell, Assistant Professor of Medicine (Medical School) and Assistant Professor of Cardiovascular Biology (Public Health)
Gary B. Ruvkun, Professor of Genetics (Medical School)
David H. Sachs, Paul S. Russell/Warner Lambert Professor of Surgery (Medical School)
Frank M. Sacks, Professor of Medicine (Medical School) and Professor in the Department of Nutrition (Public Health)
Haruo Saito, Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Leona D. Samson, Professor of Toxicology (Public Health)
John C. Samuelson, Associate Professor of Tropical Public Health (Public Health) and Clinical Fellow in Pathology (Medical School)
Clifford B. Saper, James Jackson Putnam Professor of Neurology (Medical School)
David T. Scadden, Associate Professor of Medicine (Medical School)
Robert H. Schiestl, Associate Professor of Toxicology (Public Health)
Stuart F. Schlossman, Baruj Benacerraf Professor of Medicine (Medical School)
Bruce J. Schnapp, Associate Professor of Cell Biology (Medical School)
Stuart L. Schreiber, Morris Loeb Professor of Chemistry and Chemical Biology
Thomas M. Schultheiss, Assistant Professor of Medicine (Medical School)
Peter H. Schur, Professor of Medicine (Medical School)
Brian Seed, Professor of Genetics (Medical School)
Rosalind A. Segal, Assistant Professor of Neurology (Medical School)
Christine E. Seidman, Professor of Medicine, Professor of Genetics (Medical School)
Jonathan G. Seidman, Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics (Medical School)
Dennis J. Selkoe, Professor of Neurology (Medical School)
Charles N. Serhan, Professor of Anaesthesia (Medical School)
Jeffrey E. Settleman, Associate Professor of Medicine (Medical School)
William F. Sewell, Associate Professor of Otology and Laryngology (Medical School)
Arlene H. Sharpe, Associate Professor of Pathology (Medical School)
Steven A. Shea, Assistant Professor in the Department of Environmental Health (Public Health) and Assistant Professor of Medicine (Medical School)
Jie Shen, Assistant Professor of Neurology (Medical School)
Morgan H. Sheng, Associate Professor of Neurobiology (Medical School)
Gordon Sherman, Assistant Professor of Neurology (Neuroscience) (Medical School)
Yang Shi, Associate Professor of Pathology (Medical School)
Charles B. Shoemaker, Assistant Professor of Tropical Public Health (Public Health)
Stephanie A. Shore, Associate Professor of Physiology (Public Health)
Piotr Sicinski, Assistant Professor of Pathology (Medical School)
Pamela A. Silver, Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Gary A. Silverman, Associate Professor of Pediatrics (Medical School)
Harvey B. Simon, Associate Professor of Medicine (Medical School)
David A. Sinclair, Assistant Professor of Pathology (Medical School)
Jeffrey L. Sklar, Professor of Pathology (Medical School)
Richard Owen Snyder, Assistant Professor of Pediatrics (Medical School)
Joseph G. Sodroski, Professor of Pathology Medical School and Professor of Cancer Biology (Public Health)
Sergei Y. Sokol, Associate Professor of Microbiology and Molecular Genetics (Medical School)
Bruce M. Spiegelman, Professor of Cell Biology (Medical School)
Robert G. Spiro, Professor of Biological Chemistry (Medical School)
Timothy A. Springer, Latham Family Professor of Pathology (Medical School)
Ivan Stamenkovic, Associate Professor of Pathology (Medical School)
Michael Starnbach, Assistant Professor of Microbiology and Molecular Genetics (Medical School)
Richard L. Stevens, Associate Professor of Medicine (Medical School)
Charles D. Stiles, Professor of Microbiology and Molecular Genetics (Medical School)
Thomas P. Stossel, Professor of Medicine (Medical School)
Gary R. Strichartz, Professor of Anaesthesia (Medical School)
Jack L. Strominger, Higgins Professor of Biochemistry
Kevin Struhl, David Wesley Gaiser Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Megan Sykes, Professor of Surgery (Medical School)
Jack Szostak, Professor of Genetics (Medical School)
Clifford J. Tabin, Professor of Genetics (Medical School)
Stanley Tabor, Lecturer on Biological Chemistry and Molecular Pharmacology (Medical School)
Armen H. Tashjian, Jr., Professor of Toxicology, emeritus (Public Health) and Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Daniel G. Tenen, Professor of Medicine (Medical School)
Cox Terhorst, Professor of Medicine (Medical School)
Sheila Thomas, Assistant Professor of Medicine (Medical School)
Stefan Thor, Assistant Profesor of Neurobiology (Medical School)
Li-Huei Tsai, Associate Professor of Pathology (Medical School)
Sander Van Den Heuvel, Assistant Professor of Medicine (Medical School)
Richard A. Van Etten, Associate Professor of Genetics (Medical School)
David L. Van Vactor, Assistant Professor of Cell Biology (Medical School)
Ulrich H. Von Andrian-Werburg, Associate Professor of Pathology (Medical School)
Harald Von Boehmer, Professor of Pathology (Medical School)
Denisa D. Wagner, Professor of Pathology (Medical School)
Gerhard Wagner, Elkan Blout Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Joseph Wagstaff, Assistant Professor of Pediatrics (Medical School)
W. Allan Walker, Conrad Taff Professor of Nutrition and Pediatrics (Medical School) and Professor in the Department of Nutrition (Public Health) (Medical School)
Christopher A. Walsh, Bullard Professor of Neurology (Medical School)
Christopher T. Walsh, Hamilton Kuhn Professor of Biological Chemistry and Molecular Pharmacology (Medical School)
Thomas Walz, Assistant Professor of Cell Biology (Medical School)
Gerald L. Waneck, Assistant Professor of Surgery (Medical School)
Frederick C. Wang, Associate Professor of Medicine (Medical School)
Ning Wang, Assistant Professor of Physiology and Cell Biology (Public Health)
David T. Weaver, Associate Professor of Microbiology and Molecular Genetics (Medical School)
Howard L. Weiner, Robert L. Kroc Professor of Neurology (Medical School)
Charles J. Weitz, Associate Professor of Neurobiology (Medical School)
Peter F. Weller, Professor of Medicine (Medical School)
Morris F. White, Associate Professor of Biochemistry (Medical School)
Malcolm Whitman, Associate Professor of Cell Biology (Medical School)
Louise E. Wilkins-Haug, Assistant Professor of Obstetrics, Gynecology, and Reproductive Biology (Medical School)
Walter C. Willett, Professor of Medicine (Medical School) and Frederick John Stare Professor of Epidemiology and Nutrition (Public Health)
Thomas H. Wilson, Professor of Cell Biology (Medical School)
Fred Winston, Professor of Genetics (Medical School)
Dyann F. Wirth, Professor of Tropical Public Health (Medical School, Public Health)
Chao-Ting Wu, Assistant Professor of Genetics (Medical School)
Kai Wucherpfennig, Assistant Professor of Neurology (Medical School)
Bruce Yankner, Associate Professor of Neurology (Medical School)
Gary I. Yellen, Professor of Neurobiology (Medical School)
Anne B. Young, Julieanne Dorn Professor of Neurology (Medical School)
Hagop Youssoufian, Assistant Professor of Medicine (Medical School)
Junying Yuan, Associate Professor of Cell Biology (Medical School)
Edmund J. Yunis, Professor of Pathology (Medical School)
Bruce R. Zetter, Professor of Surgery (Medical School)
Jing Zhou, Associate Professor of Medicine (Medical School)
Leonard I. Zon, Associate Professor of Pediatrics (Medical School)

The Division of Medical Sciences makes available to graduate students the facilities of the preclinical departments and research laboratories of the Harvard Medical School and its affiliated hospitals and institutions. The Division offers advanced courses and research in cell biology, biological chemistry and molecular pharmacology, physiology, genetics, immunology, microbiology and molecular genetics, neurosciences, pathology, and virology. Qualified undergraduates may be admitted with the permission of the instructor and the student’s department of concentration, as far as the facilities of the special laboratories permit. Inquiries should be addressed to the Division of Medical Sciences, Harvard Medical School, 260 Longwood Avenue, Boston, MA 02115, or telephone (617) 432-0162.

For other courses in biological sciences, see listings of the Program in Biological Sciences in Public Health, Biophysics and Molecular and Cellular Biology.

Biological and Biomedical Sciences (BBS)


BBS is an interdepartmental program within the Division of Medical Sciences at Harvard Medical School. BBS faculty are primarily drawn from five preclinical departments of the Medical School: Biological Chemistry and Molecular Pharmacology (BCMP); Cell Biology; Genetics; Microbiology and Molecular Genetics; and Pathology. In addition, selected faculty located within area hospitals and institutions are members of BBS.

Graduate Courses of Reading and Research

*BBS 300. BBS Seminar
Catalog Number: 8771
Clifford J. Tabin (Medical School) 2430, Patricia A. D’Amore (Medical School) 1168, and Robert E. Kingston (Medical School) 1153
This seminar is designed to help students learn presentation skills. Each student in their fourth year will be required to give a 20 minute talk to other fourth year students and selected faculty. The talk will be based upon the research in the student’s thesis lab (ie. a "lab" talk, not necessarily the student’s own research.) The course faculty will help in the preparation of the talk and will give feedback following the talk. Students must register for this course by their fifth year.

*BBS 333r (formerly Medical Sciences 333r). Introduction to Research in Biological and Biomedical Sciences
Catalog Number: 1206
Constance L. Cepko (Medical School) 1150

*BBS 380 (formerly Medical Sciences 380). Reading and Research in Biological and Biomedical Sciences
Catalog Number: 0349
Constance L. Cepko (Medical School) 1150

Biological Chemistry and Molecular Pharmacology


All courses in Biological Chemistry and Molecular Pharmacology are subject to limitation in enrollment and will not be offered unless there is sufficient demand. For courses in Neuropharmacology, see listings under Neurobiology. For more courses in biochemistry, see other listings in the FAS Biological Sciences section.

Primarily for Graduates

BCMP 200. Molecular Biology
Catalog Number: 5591
Stephen Buratowski (Medical School), David E. Fisher (Medical School) and associates
Half course (fall term). M., W., F., 10:30–12.
An advanced treatment of the Central Dogma of molecular biology. The course will consider the molecular basis of genetic information transfer from DNA to RNA to protein, using current examples from eukaryotic and prokaryotic systems. Topics include DNA and chromatin structure, replication, DNA repair, genome stability and plasticity, transcription, post-transcriptional RNA processing, translation, and post-translational regulation. Lectures and discussion sessions will emphasize experimental techniques and primary literature readings.
Note: Offered jointly with the Medical School as BP 723.0.
Prerequisite: Intended primarily for graduate students familiar with basic molecular biology or with strong biology/chemistry background.

BCMP 201. Proteins: Structure, Function and Catalysis
Catalog Number: 5068
Thomas E. Ellenberger (Medical School), Stephen C. Blacklow (Medical School), Stephen C. Harrison, and Christopher T. Walsh (Medical School)
Half course (spring term). Tu., Th., 9:30–11, W., 4:30–6; First class meets 1/30/01.
Advanced coverage of contemporary topics in protein biochemistry with emphasis on the interrealted roles of protein structure, catalytic activity, and macromolecular interactions in biological processes. Topics include the analysis of protein sequence information and three dimensional structures of proteins, protein folding and conformational changes that control biological activity, intracellular targeting of proteins, the regulated assembly and disassembly of macromolecular complexes, the structural basis for enzymatic catalysis, fidelity and proofreading mechanisms, energy transduction, and the generation of force by proteins.
Note: Offered jointly with the Medical School as BP714.0
Prerequisite: Knowledge of introductory general biochemistry , elementary physical chemistry, and molecular genetics required.

*BCMP 205. Principles of Pharmacology
Catalog Number: 1737
David E. Golan (Medical School) and members of the Department
Half course (spring term). M., through F., 8:30–12. First class meets 2/08/01, class ends 3/9/01.
Intensive introduction to pharmacology, emphasizing basic mechanisms of drug action and principles of drug-receptor interactions, pharmacokinetics, and drug metabolism. Drug classes illustrated using prototypic drugs. Examples drawn from autonomic nervous system, cardiovascular, and central nervous system pharmacology; autacoids and chemotherapeutic agents also considered.
Note: Offered jointly with the Medical School as IN 705.0. Ten hours of lecture, four hours of conference, and four hours of tutorial per week. Permission of both the course director and the Medical School Registrar is required.
Prerequisite: Introductory biochemistry and physiology preferred but not required.

BCMP 207. Molecular Approaches to Drug Action, Discovery, and Design
Catalog Number: 0529 Enrollment: May be limited.
Donald M. Coen (Medical School), David E. Golan (Medical School), James M. Hogle (Medical School), Christopher T. Walsh (Medical School), Morris F. White (Medical School) and Associates
Half course (spring term). Tu., Th., 3:30–5:30.
Explores how molecular biology, structural biology, and modern enzymology have revolutionized understanding of selective drug action and development of new therapies. Analyzes molecular underpinnings of basic pharmacological principles. Examples drawn primarily from pathways central to molecular biology such as signal transduction, DNA replication, and gene expression with application to diseases including cancer, diabetes, and AIDS.
Note: Offered jointly with the Medical School as BP 715.0. Intended primarily for graduate students.

BCMP 210. Theory and Practice of Techniques in Molecular Biology
Catalog Number: 1230
Welcome W. Bender (Medical School), Donald K. Morisato (Medical School), and Stanley Tabor (Medical School)
Half course (spring term). M., 2–4, W., 2–5, F., 2–4.
Reviews the principles of common lab techniques, and discusses recent innovations. A variety of procedures will be tested experimentally. Topics include separation techniques for nucleic acids and proteins, polymerase reactions, nucleic acid reassociations, and biological database searching and analysis. Course format includes lecture, lab experiments, and discussions.
Note: Offered jointly with the Medical School as BP 725.0.
Prerequisite: Exposure to molecular techniques will be assumed.

*BCMP 213. Behavioral Pharmacology
Catalog Number: 4782 Enrollment: Limited to 15.
Jack Bergman (Medical School), William H. Morse (Medical School) and associates
Half course (spring term). Tu., 2–5.
Introduction to CNS pharmacology and behavior. Effects of psychomotor stimulants, antischizophrenics, opioid analgesics, and antianxiety agents on behavior. Emphasis on methodology, pharmacological analysis, and drug dependence; attention to tolerance, withdrawal, and self-administration of drugs.
Note: Offered jointly with the Medical School as BP 719.0.

[BCMP 225. Biochemistry of Muscle]
Catalog Number: 3442 Enrollment: Limited to 10. Maximum 10.
John Gergely (Medical School)
Half course (spring term). Tu., Th., 3–5.
Topics: properties and interactions of myofibrillar proteins; molecular architecture of contractile apparatus; regulatory proteins; role of calcium ions in excitation-contraction coupling; regulation of intracellular calcium ion concentration; models of muscle contraction and their relation to molecular properties of myofibrillar proteins. Applications to diseases of skeletal and cardiac muscles.
Note: Expected to be given in 2001–02. Given in alternate years. Offered jointly with the Medical School as BP 703.0.
Prerequisite: Introductory biochemistry.

BCMP 228. Macromolecular Crystallography and NMR
Catalog Number: 3969
Gerhard Wagner (Medical School) and James M. Hogle (Medical School)
Half course (fall term). Hours to be arranged.
Theory and practice of modern methods of structural analysis: model building of proteins and DNA, growing protein crystals, making a heavy atom derivative, taking X-ray precession photographs, solving a protein structure; setup of 2D NMR experiments, spectral assignment distance geometry, and other modeling programs on graphics workstations. The two parts of this course, Macromolecular Crystallography and Macromolecular NMR, can be taken together as a half course, or individually as a quarter course under BCMP 370.
Note: Contact instructor at 432-3213. Offered in alternate years. Offered jointly with the Medical School as BP 722.0.

BCMP 230. Principles and Practice of Drug Development
Catalog Number: 1295
Robert H. Rubin (Medical School)
Half course (fall term). Th., 3–6.
Critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules. Economic considerations of the drug development process. Multidiciplinary perspective from faculty from clinical, life, and management sciences and industry guests.
Note: Offered jointly with the Medical School as HT920.

Graduate Courses of Reading and Research

*BCMP 300. Enzyme Mechanisms
Catalog Number: 1867
Christopher T. Walsh (Medical School) 2036

*BCMP 304. Selenoproteins and Translational Control of Gene Expression
Catalog Number: 2268
Marla J. Berry (Medical School) 2061

*BCMP 305. Mechanisms of Visual Transduction and Adaptation and Biochemical Mechanisms of Drug Action
Catalog Number: 0834
Robert R. Rando (Medical School) 4125

*BCMP 307. Hormone Receptor Interaction in Bone Biology
Catalog Number: 3484
Michael Rosenblatt (Medical School) 1138

*BCMP 309. Regulation of Membrane Protein and Lipid Dynamics: Molecular Mechanisms and Biological Implications
Catalog Number: 1558
David E. Golan (Medical School) 1558

*BCMP 310. Molecular and Cellular Mechanisms of Insulin Action
Catalog Number: 4299
Morris F. White (Medical School) 3158

*BCMP 311 (formerly Microbiology 337). Structure of Viruses, Viral Proteins, Receptors, Transcription Factors
Catalog Number: 3623
Stephen C. Harrison 3597

*BCMP 312. Molecular Mechanisms of DNA Damage and Repair and Mutagenesis
Catalog Number: 0828
Irving H. Goldberg (Medical School) 3677

*BCMP 315. Growth Factor Structure and Biological Activity
Catalog Number: 6034
Michael Klagsbrun (Medical School) 3167

*BCMP 316. Design and Synthesis of Novel Folic Acid Antagonists and Nucleotide Analogs as Anticancer and Antiviral Agents
Catalog Number: 0857
Andre Rosowsky (Medical School) 3527

*BCMP 320. Cell Biology of Eukaryotes
Catalog Number: 0265
Pamela A. Silver (Medical School) 1595

*BCMP 321. Structure and Function of DNA Replication and Repair Proteins
Catalog Number: 7298
Thomas E. Ellenberger (Medical School) 1643

*BCMP 323. Biochemistry of Muscle Contraction
Catalog Number: 2794
John Gergely (Medical School) 2477

*BCMP 324. Structure and Replication of DNA
Catalog Number: 5059
Charles C. Richardson (Medical School) 2479

*BCMP 325. Genomic Instability and Cancer Susceptibility
Catalog Number: 4110
Alan D. D’Andrea (Medical School) 3532

*BCMP 326. Molecular Mechanisms of Drosophila Development
Catalog Number: 1248
Donald K. Morisato (Medical School) 1803

*BCMP 329. Structure Biology of Cytoplasmic Signal Transduction
Catalog Number: 5005
Michael J. Eck (Medical School) 1739

*BCMP 332. Structural Neurology
Catalog Number: 0276
Peter T. Lansbury (Medical School) 2115

*BCMP 333. Regulation of Biosynthetic Processes
Catalog Number: 4876
Henry P. Paulus (Medical School) 1205

*BCMP 334. Signal Transduction Across the Plasma Membrane
Catalog Number: 6616
Eva J. Neer (Medical School) 2214

*BCMP 335. Biochemical and Genetic Analysis of Eukaryotic Gene Expression
Catalog Number: 8052
Stephen Buratowski (Medical School) 1790

*BCMP 336. Structure, Function, and Assembly of Glycoprotein Components of Biomembranes
Catalog Number: 1726
Robert G. Spiro (Medical School) 2493

*BCMP 337. Drosophila Molecular Genetics
Catalog Number: 0782
Welcome W. Bender (Medical School) 7083

*BCMP 338. Eukaryotic Gene Regulation
Catalog Number: 0549
Kevin Struhl (Medical School) 7415

*BCMP 341. Electron Paramagnetic Resonance Spectroscopy
Catalog Number: 0837
Keith W. Miller (Medical School) 4124

*BCMP 342. Signal Transduction in Eukaryotic Cells
Catalog Number: 4557
Haruo Saito (Medical School) 2028

*BCMP 343. Molecular Genetics of Herpes Viruses
Catalog Number: 0868
Donald M. Coen (Medical School) 7617

*BCMP 344. Molecular Pharmacology of Excitable Membranes
Catalog Number: 0200
Gary R. Strichartz (Medical School) 7530

*BCMP 346. Lipid Mediators in Cell Signalling
Catalog Number: 8258
Charles N. Serhan (Medical School) 3163

*BCMP 347. Structural Analysis of Viruses and Receptors
Catalog Number: 5105
Thilo Stehle (Medical School) 4990 (Medical School)

*BCMP 351. Molecular and Cellular Endocrinology
Catalog Number: 0208
Armen H. Tashjian, Jr. (Medical School) 2071

*BCMP 356. Solution Structures of Proteins by NMR Spectroscopy
Catalog Number: 8093
Gerhard Wagner (Medical School) 2626

*BCMP 357. Problems in Nucleic Acid and Nucleic Acid/Protein Crystallography
Catalog Number: 6132
Christin A. Frederick (Medical School) 2614

*BCMP 359. Molecular Mechanisms of Signal Transduction
Catalog Number: 8520
Elaine A. Elion (Medical School) 2941

*BCMP 360. Regulating Skeletal Myogenesis
Catalog Number: 6934
Andrew B. Lassar (Medical School) 2946

*BCMP 361. X-Ray Crystallographic Studies of Viruses and Proteins
Catalog Number: 4155
James M. Hogle (Medical School) 2943

*BCMP 362. Eukaryotic Survival Decisions
Catalog Number: 4972
David E. Fisher (Medical School) 1800

*BCMP 363. The Mechanics and Regulation of Mitosis
Catalog Number: 4981
David Pellman (Medical School) 3702

*BCMP 370. Advanced Topics in Biological Chemistry and Molecular Pharmacology
Catalog Number: 0482
Donald K. Morisato (Medical School) 1803 and James M. Hogle (Medical School) 2943
A series of reading and discussion seminars, each running for a half semester (7 weeks). Two seminars, which can be taken in different semesters, are required for credit.
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0605 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.
Prerequisite: Dependent on seminar.

*BCMP 371. Characterization of Eukaryotic Replication Initiation Factors. Initiation of Eukaryotic DNA Replication: A Biochemical Analysis
Catalog Number: 3739
Johannes Walter (Medical School) 3846

*BCMP 372. Methods and Applications in Computational Molecular Biology
Catalog Number: 1638
Frederick P. Roth (Medical School) 3912

Cross-Listed Courses

Biophysics 101. Genomics and Computational Biology

Cell Biology

Primarily for Graduates

Cell Biology 201. Molecular Biology of the Cell
Catalog Number: 1044
Rong Li (Medical School), Tom Rapaport (Medical School), Marc W. Kirschner (Medical School), Timothy J. Mitchison (Medical School), and Frank D. McKeon (Medical School)
Half course (spring term). M., W., at 10:30-12; plus sections F. at 10:30-12.
Current concepts in Cell Biology and Biochemistry, with emphasis on experimental approaches. Topics include cellular architecture, the molecular basis of cellular compartmentalization, protein trafficking, protein degradation, cytoskeleton, molecular motors, cell division cycle, signal transduction, and the cellular/biochemical basis of diseases. The course will also cover various methods, such as protein purification, sequencing, analysis of protein-protein interactions, and others.
Note: Offered jointly with the Medical School as CB 7130.
Prerequisite: Basic knowledge in biochemistry and genetics.

Cell Biology 206. Physiology of Normal and Transformed Cells
Catalog Number: 4804 Enrollment: Minimum of 4.
Claude P. Lechene (Medical School)
Half course (spring term). Hours to be arranged.
Cellular homeostasis, (Na+2,K+2)-pump, intracellular pH signal transduction through integrins, membrane events and cellular growth and division. Discussion of altered regulation of membrane events by specific oncoproteins.
Note: Given in alternate years. Offered jointly with the Medical School as CB 703.0.

Cell Biology 207. Developmental Biology: Molecular Mechanisms of Vertebrate Development
Catalog Number: 2044 Enrollment: Limited to 25.
Mark Mercola (Medical School), John G. Flanagan (Medical School), Andrew B. Lassar (Medical School), Thomas M. Schultheiss (Medical School), Sergei Y. Sokol (Medical School), Clifford J. Tabin (Medical School), and Malcolm Whitman (Medical School)
Half course (spring term). Tu., Th., 2–4.
Analysis of the developmental programs of frog, chick, and mouse embryos with emphasis on experimental strategies for understanding the responsible molecular mechanisms. The course discusses the formation of the basic body plan and the formation of selected organs. General mechanisms of patterning and morphogenesis will be emphasized. Topics include developmental anatomy of early embryos, primary axis formation and regional specification, formation of the nervous system and eye development, establishment of cell fate, homeotic genes and the control of pattern, cell migration and cell-cell signalling, muscle, heart, kidney and limb development. Course includes lectures and conferences. Two short research proposals will be required in lieu of exams.
Note: Offered jointly with the Medical School as CB 710.0.
Prerequisite: Microbiology 201 or equivalent.

[Cell Biology 211a. Biology of the Cancer Cell]
Catalog Number: 5771
James A. DeCaprio (Medical School) and Myles A. Brown (Medical School)
Half course (fall term). Hours to be arranged.
Examines the basic mechanisms of cell growth and the processes that lead to tumorgenesis. Emphasizes the molecular basis of growth control and includes studies of growth factors, membrane receptors, intracellular signal transduction, cell cycle control, apoptosis, transcription, and DNA repair. Focuses on oncogenes, tumor suppressors, and how oncogenic viruses regulate cell growth.
Note: Expected to be given in 2001–02. Given in alternate years. Offered jointly with the Medical School as CB 704.0.
Prerequisite: General knowledge of biochemistry, molecular genetics, and cell biology.

Cell Biology 211b. Growth Factors and Signal Transduction
Catalog Number: 4169 Enrollment: Limited to 30.
Charles D. Stiles (Medical School), Alan D. D’Andrea (Medical School), and Thomas M. Roberts (Medical School)
Half course (fall term). Hours to be arranged. EXAM GROUP: 6, 7
The course is divided into three instruction blocks. The first block covers history, chemistry and biology of the major growth factor families and their receptors including the hematopoietic growth factors. The second block teaches basic principles in growth factor receptor activation and signal transduction. The Ras/Raf/MAP kinase cascade and the JAK/STAT signaling pathways are used as teaching vehicles. The third instruction block is entitled “Variations on the Themes and a Look Ahead.” The content of this block will change as the field unfolds. Most recently (Fall of ’98), this block featured one lecture “snapshots” of TGF-beta receptor signaling, Eph family receptors and their ligands, tyrosine phosphatases, Notch/Delta, Wnt and Patched signaling pathways.
Note: Given in alternate years. Offered jointly with the medical school as CB 705.0.
Prerequisite: BCMP/CB 201 or equivalent.

[Cell Biology 213. Biological Machines]
Catalog Number: 8427
Robin Reed (Medical School), Thomas E. Ellenberger (Medical School), Daniel Finley (Medical School), Tomas Kirchhausen (Medical School), Danesh Moazed (Medical School), Tom Rapoport (Medical School), Bruce J. Schnapp (Medical School), and Gary I. Yellen (Medical School)
Half course (fall term). M., W., F., 2–4.
Most major cellular processes are carried out by complex macromolecular machines. The course will investigate the basic principles of these machines by exploring specific examples, including the proteasome, chaperones, nucleocytoplasmic transport machinery, the spliceosome, protein translocation machinery, ion channels, DNA polymerases and topoisomerases, molecular motors and chromatin remodeling machinery. We will examine the structure and assembly of these machines, the mechanisms they use to achieve fidelity, how and why energy is used, the role of conformational changes, and reasons for the extreme complexity of many of the machines. The format will be essentially a workshop, with frequent presentations by students. The material will be focused on the current literature, with an emphasis on experimental design and proposing new experiments.
Note: Expected to be given in 2001–02. Given in alternate years. Course web site is http://cbweb.med.harvard.edu/biomachine/. The BioInformation Systems Manager will be Scott Storms, PhD. Offered jointly with the Medical School as CB 719.0
Prerequisite: Undergraduate level biochemistry, molecular biology, cell biology.

Graduate Courses of Reading and Research

*Cell Biology 300. Advanced Topics in Cell, Molecular, and Developmental Biology
Catalog Number: 5825
Alfred L. Goldberg (Medical School) 2827 and members of the Faculty
Half course (fall term; repeated spring term). Hours to be arranged.
Topics cover areas of interest in cell, molecular, and developmental biology such as spatial organization of cytoplasm, apoptosis, membrane trafficking, and tumor progression and metastasis. Different topics are covered each term.
Note: A series of reading and discussion seminars, each running for a half semester (seven weeks). Two seminars, which can be taken in different semesters, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0605 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.
Prerequisite: Dependent on seminar.

*Cell Biology 304. Regulation of the Cell Cycle
Catalog Number: 0414
Joan V. Ruderman (Medical School) 2622

*Cell Biology 305. Developmental Biology
Catalog Number: 3314
Elizabeth D. Hay (Medical School) 1011

*Cell Biology 306. Permeability and Biological Transport
Catalog Number: 0416
Thomas H. Wilson (Medical School) 2137

*Cell Biology 307. Cell–Cell Signaling in Neural Development
Catalog Number: 1911
John G. Flanagan (Medical School) 3149

*Cell Biology 308. Membrane Biology
Catalog Number: 6173
Dennis A. Ausiello (Medical School) 1288

*Cell Biology 309. RNA Splicing and Nuclear Export of mRNA
Catalog Number: 2523
Robin Reed (Medical School) 2319

*Cell Biology 313. The Structure of the Nucleus and the Dynamics of Nuclear Transport
Catalog Number: 3151
Frank D. McKeon (Medical School) 1990

*Cell Biology 314. Molecular Biology of Extracellular Matrix
Catalog Number: 5077
Bjørn R. Olsen (Dental School, Medical School) 1164

*Cell Biology 316. Mechanism and Regulation of Intracellular Protein Turnover
Catalog Number: 1017
Alfred L. Goldberg (Medical School) 2827

*Cell Biology 317. Mechanisms of Programmed Cell Death
Catalog Number: 2270
Junying Yuan (Medical School) 2105

*Cell Biology 318. Molecular Biology of Cell Growth Regulation and Transformation
Catalog Number: 3355
John Blenis (Medical School) 2612

*Cell Biology 319. Cell Polarity and Morphogenesis
Catalog Number: 2986
Rong Li (Medical School) 2106

*Cell Biology 320. Mechanisms of Intracellular Transport
Catalog Number: 4285
Bruce J. Schnapp (Medical School) 2948

*Cell Biology 321. Neuronal Pathfinding and Guidance
Catalog Number: 4841
David L. Van Vactor (Medical School) 2089

*Cell Biology 322. Endothelial Cell Proliferation in Angiogenic Diseases
Catalog Number: 5980
Joyce E. Bischoff (Medical School) 1448

*Cell Biology 323. Biology of Membranes and Intercellular Junctions
Catalog Number: 2651
Daniel A. Goodenough (Medical School) 4077

*Cell Biology 325. RNA Localization in Neurons and Determination of Neuronal Fates
Catalog Number: 4485
Kenneth S. Kosik (Medical School) 1814

*Cell Biology 326. Signal Transduction During Early Development
Catalog Number: 1872
Malcolm Whitman (Medical School) 3267

*Cell Biology 328. Receptor-Mediated Endocytosis
Catalog Number: 0438
Tomas Kirchhausen (Medical School) 1155

*Cell Biology 329. The Ubiquitin–Proteasome Pathway
Catalog Number: 6826
Daniel Finley (Medical School) 2313

*Cell Biology 331. Growth Factors in Vertebrate Development
Catalog Number: 5258
Mark Mercola (Medical School) 2947

*Cell Biology 333. High-resolution Electron Microscopy
Catalog Number: 9254
Thomas Walz (Medical School) 3778

*Cell Biology 334 (formerly Microbiology 334). Molecular Analysis of Tyrosine Phosphatases
Catalog Number: 2447
Benjamin Neel (Medical School) 2486

*Cell Biology 335. Signal Transduction
Catalog Number: 2542
Lewis C. Cantley (Medical School) 1287

*Cell Biology 336. Signal Transduction in Normal and Transformed Cells
Catalog Number: 6833
Joan S. Brugge (Medical School) 1486

*Cell Biology 337. Keratinocyte Growth and Differentiation
Catalog Number: 2197
Howard Green (Medical School) 7318

*Cell Biology 338. Developmental Biology of Human Congenital Anomalies
Catalog Number: 7867
Patricia K. Donahoe (Medical School) 3252

*Cell Biology 339. Cell Morphogenesis and Regulation
Catalog Number: 3898
Marc W. Kirschner (Medical School) 1078

*Cell Biology 342. Cytoskeleton in Development and Cancer
Catalog Number: 4059
Sheila Thomas (Medical School) 3777

*Cell Biology 343. Mechanisms of Mammalian Cell Differentiation and Gene Expression
Catalog Number: 0202
Bruce M. Spiegelman (Medical School) 7733

*Cell Biology 344. Molecular Mechanism of Signal Transduction
Catalog Number: 6093
Xi He (Medical School) 2004

*Cell Biology 345. Protein Transport Across the Endoplasmic Reticulum Membrane
Catalog Number: 6793
Tom Rapoport (Medical School) 1815

*Cell Biology 346. Signal Transduction by Receptor Throsine Kinases
Catalog Number: 1591
Andrius Kazlauskas (Medical School) 2088

*Cell Biology 347. Cellular and Molecular Aspects of Insulin Action
Catalog Number: 1494
C. Ronald Kahn (Medical School) 2019

*Cell Biology 348. Structure, Function, and Development of Membrane Skeletons
Catalog Number: 6638
Samuel E. Lux IV (Medical School) 7403

*Cell Biology 349. Chromosome Structure and Gene Silencing in Yeast
Catalog Number: 8765
Danesh Moazed (Medical School) 4254

*Cell Biology 352. Vertebrate Embryology, Organogenesis, and Cell Differentiation
Catalog Number: 9231
Thomas M. Schultheiss (Medical School) 2236

*Cell Biology 353. Regulation of Epithelial Morphogenesis by TGF-beta Family Signaling
Catalog Number: 8239
Laurel A. Raftery (Medical School) 8686

*Cell Biology 354. Molecular Mechanisms of Intracellular Transport
Catalog Number: 7605
Victor Wee Hsu (Medical School) 2606

*Cell Biology 355. Cell Interactions in Organ Morphogenesis
Catalog Number: 1662
Merton Bernfield (Medical School) 1156

*Cell Biology 356. Cell Growth Regulation, Telomere Maintenance and Human Diseases
Catalog Number: 3718
Kun Ping Lu (Medical School) 2607

*Cell Biology 357. Signal Transduction and Animal Cell Movement
Catalog Number: 5835
Thomas P. Stossel (Medical School) 7734

*Cell Biology 358. Mechanisms of Tumor Metastasis
Catalog Number: 0606
Bruce R. Zetter (Medical School) 7737

*Cell Biology 359. Intracellular Signaling Pathways in the Regulation of Cell Growth and Differentiation
Catalog Number: 0335
David A. Frank (Medical School) 3276

*Cell Biology 372. Cytoskeletal Dynamics
Catalog Number: 5032
Timothy J. Mitchison (Medical School) 3713

*Cell Biology 373. Molecular Genetics of Cell Interaction in Development
Catalog Number: 8133
Spyros Artavanis-Tsakonas (Medical School) 2609

*Cell Biology 375. Molecular and Cellualr Mechanisms of Regeneration. Molecular Genetics of Cardiovascular Diseases
Catalog Number: 0435
Mark T Keating

Genetics

Primarily for Graduates

*Genetics 200. Genetics Development and Reproductive Biology
Catalog Number: 4265 Enrollment: Limited to 4. Limited to 4 Division of Medical Sciences students.
Philip Leder (Medical School), Daniel D. Federman (Medical School), Bruce R. Korf (Medical School), and Clifford J. Tabin (Medical School)
Half course (spring term). M. through F., 8:30–12:30 First class meets 3/19/01 at 10:15 am. Call 432-0904.
Focuses on fundamental aspects of human genetics, reproduction, early development, and morphogenesis. Both classical and molecular genetics are addressed, with particular application to human biology and medicine. Laws that govern inheritance and variation among individuals and populations considered with special attention to the molecular aspects of inheritance, mutation, and gene control.
Note: Call 432-1315 to register. Permission of both the course director and the Medical School Registrar is required. Offered jointly with the Medical School as IN 703.0.
Prerequisite: Biochemistry or equivalent.

Genetics 201. Principles of Genetics
Catalog Number: 4225
William F. Dietrich (Medical School), Iswar K. Hariharan (Medical School), Anne C. Hart (Medical School), Ann Hochschild (Medical School), and Fred Winston (Medical School)
Half course (fall term). M., W., F., 9–10:30.
An in-depth survey of genetics, beginning with basic principles and extending to modern approaches and special topics. To illustrate the principles of genetics, we will draw on examples from various systems, such as Drosophila, C. Elegans, Saccharomyces, mouse, human and bacteria. In addition, considerable time will be spent discussing important practical aspects and constraints of genetic analysis in various organisms. Section meetings will focus on critical discussion of papers from the literature and on discussion of problem sets.
Note: Intended for first-year graduate students. Offered jointly with the Medical School as GN 701.0.

Genetics 212. Biology of Yeasts: Cell Proliferation and Differentiation
Catalog Number: 3476
Elaine A. Elion (Medical School)
Half course (spring term). W., 1:30–4:30.
This course will consider topics such as cell cycle control, determination of cell identity and cell morphology from the perspective of studies using yeasts as the experimental organism. We will concentrate on examining how scientific problems can be studied in these simple eukaryotes using genetic methods. Primary research papers will be discussed and critically evaluated. The two parts of this course can be taken together as a half course, or individually as quarter courses under BCMP 370/CB 300. The first quarter will consider determination of cell identity and control of cell differentiation; the second quarter will consider cell cycle control and morphogenesis.
Note: Offered jointly with the Medical School as GN 722.0.
Prerequisite: Genetics 201 or equivalent. May be taken concurrently.

Genetics 214. Biology of the Visual System
Catalog Number: 5537 Enrollment: Limited to 20. Minimum 5; maximum 20.
Constance L. Cepko (Medical School), Richard T. Born (Medical School), John E. Dowling, Thaddeus P. Dryja, Jr. (Medical School), John G. Flanagan (Medical School), Ilene K. Gipson (Medical School), Francesca Pignoni (Medical School), Robert R. Rando (Medical School), and Elio Raviola (Medical School)
Half course (fall term). M., W., 3–5.
An introduction to the visual system focusing on the vertebrate visual system, primarily on the retina, but with some coverage of other visual centers. Covers aspects of anatomy, physiology, biochemistry, development, and molecular genetics.
Note: Given in alternate years. An introductory course in neurobiology is suggested, but not required. Offered jointly with the Medical School as GN 714.0.

Genetics 216. Advanced Topics in Gene Expression
Catalog Number: 2244
Robert E. Kingston (Medical School) and Fred Winston (Medical School)
Half course (spring term). Tu., 1–4.
This course will cover both biochemical and genetic studies in regulatory mechanisms. We will discuss a small number of topics in depth, using the primary literature as the main source of information. Each area of research covered will be analyzed in terms of the conceptual basis for its study, its advancement and evolution, and the experimental approaches that were used. Topics will range from prokaryotic transcription to eukaryotic development.
Note: Offered jointly with the Medical School as GN 703.0.
Prerequisite: BCMP 200 and Genetics 201.

Genetics 218. Genotype to Phenotype: Epigenetic and Other Forms of Gene Regulation
Catalog Number: 2252 Enrollment: Limited to 15.
Chao-Ting Wu (Medical School), William C. Forrester (Medical School), and Jeannie T. Lee (Medical School)
Half course (spring term). Th., 1–4.
There is increasing interest in apparently unusual forms of gene regulation, many of which have been described as epigenetic. We will explore a selection of these phenomena, including X-inactivation, transvection, methylation, parental imprinting, RIP, MIP, quelling, co-suppression, and paramutation. Examples will be taken from prokarytokes, ciliates, fungi, plants, insects, and mammals. While the underlying bases for these processes may seem diverse, we will aim to identify unifying themes. The course format will entail paper discussions, lectures, and student presentations.
Note: Offered jointly with the Medical School as GN 724.0.
Prerequisite: Introductory course in genetics and molecular biology, or permission of the instructors.

Genetics 220. Molecular Biology and Genetics in Modern Medicine
Catalog Number: 4660
Nadia Rosenthal (Medical School) and David Hausman (Medical School) and associates
Half course (fall term). M., F., 9:30–12.
The focus of this course is on the scientific, clinical, and ethical aspects of modern human genetics. Basic science lectures covering genetic approaches and molecular underpinnings of inherited diseases are integrated with patient presentations and discussion. An outside project puts each student in direct contact with clinicians, researchers, and patients dealing in a particular disorder. During the first portion of the semester fundamental principles of human genetics are presented to the class. During these early sessions, students with stronger backgrounds meet in alternative sections with leading researchers to discuss related advanced topics based on reading of primary literature.
Note: Offered jointly with the Medical School as HT 160.

Graduate Courses of Reading and Research

*Genetics 300. Advanced Topics in Cell, Molecular, and Developmental Biology
Catalog Number: 1037
Susan M. Dymecki (Medical School) 1736
Topics cover areas of interest in cell, molecular, and developmental biology such as molecular genetics of learning and memory, conservation of embryological mechanisms, molecular organogenesis, and biology of yeasts. Different topics are covered each term.
Note: A series of reading and discussion seminars, each running for a half semester (seven weeks). Two seminars, which can be taken in different semesters, are required for credit. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0605 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.
Prerequisite: Dependent on seminar.

*Genetics 301. Research in Molecular Genetics and Molecular Oncology
Catalog Number: 4780
Philip Leder (Medical School) 7527

*Genetics 302. Molecular Biology of Plants: Control of Eukaryotic Gene Expression
Catalog Number: 3650
Howard M. Goodman (Medical School) 7526

*Genetics 303. Pathogenesis
Catalog Number: 1972
Frederick Ausubel (Medical School) 4639

*Genetics 304. Molecular Genetics Basis of Human Disease, Particularly Cardiovascular Pathogenesis
Catalog Number: 0693
Christine E. Seidman (Medical School) 3013

*Genetics 305. Genetics, Receptors and Ion Channels
Catalog Number: 9027
Jing Zhou (Medical School) 3779
Half course (spring term). .

*Genetics 306. Inherited Human Disorders
Catalog Number: 7324
Jonathan G. Seidman (Medical School) 7529

*Genetics 307. Hormonal Control of Gene Expression in Higher Organisms
Catalog Number: 2938
David D. Moore (Medical School) 7876

*Genetics 308. Molecular Biology of Signal Transduction
Catalog Number: 5616
Brian Seed (Medical School) 7619

*Genetics 309. Gene Expression in Yeast
Catalog Number: 3763
Fred Winston (Medical School) 7877

*Genetics 310. Molecular Approaches to Developmental Neurobiology
Catalog Number: 6324
Constance L. Cepko (Medical School) 1150

*Genetics 311. Molecular Mechanisms of Transcription Regulation in Mammals
Catalog Number: 7310
Robert E. Kingston (Medical School) 1153

*Genetics 312. Molecular Genetics of Development
Catalog Number: 8363
Gary B. Ruvkun (Medical School) 1366

*Genetics 314. Structure and Activities of Ribozymes
Catalog Number: 7244
Jack Szostak (Medical School) 7096

*Genetics 315. Molecular Genetics of Inherited Disorders
Catalog Number: 3362
James Gusella (Medical School) 1152

*Genetics 317. Targeted Mutagenesis in Mice to Study Molecular Control of Development
Catalog Number: 2271
Jordan A. Kreidberg (Medical School) 2080

*Genetics 318. Genome Structure
Catalog Number: 5012
George M. Church (Medical School) 1608

*Genetics 319. Mouse Models of Human Disorders
Catalog Number: 0860
David R. Beier (Medical School) 3519

*Genetics 320. Contribution of Placental Karyotype Abnormalities to Adverse Pregnancy Outcomes
Catalog Number: 2989
Louise E. Wilkins-Haug (Medical School) 2097

*Genetics 321. Genetics of Embryonic Development in Drosophila
Catalog Number: 6501
Norbert Perrimon (Medical School) 1679

*Genetics 322. Vertebrate Pattern Formation
Catalog Number: 0436
Clifford J. Tabin (Medical School) 2430

*Genetics 323. Molecular Biology of V(D)J Recombination
Catalog Number: 6950
Marjorie A. Oettinger (Medical School) 3172

*Genetics 324. Transformation and Leukemogenesis by abl Oncogenes; Hematopoiesis
Catalog Number: 7286
Richard A. Van Etten (Medical School) 3266

*Genetics 326. Genetics of TSC and Motility
Catalog Number: 2900
David J. Kwiatkowski (Medical School) 3770

*Genetics 327. Mammalian Cell Cycle Control
Catalog Number: 1535
Edward E. Harlow (Medical School) 2863

*Genetics 328. Lymphocyte Differentiation, Recombination, and Nuclear Oncogenes
Catalog Number: 2702
Frederick W. Alt (Medical School) 3146

*Genetics 330. Critical Thinking and Research Proposal Writing
Catalog Number: 0210 Enrollment: Open to all BBS students; others need approval of the instructor.
Alan M. Michelson (Medical School) 2029 and members of the Faculty
Half course (fall term). Tutorials to be scheduled individually by each group.
This course provides thorough coverage of the essential elements of hypothesis-driven research proposal writing. Through a series of written exercises and class discussions, students will learn how to choose an appropriate research subject, define specific scientific hypotheses to advance the understanding of the chosen topic, design a series of properly controlled experiments to investigate these questions, anticipate potential outcomes and technical pitfalls of the proposed experiments, and consider alternative interpretation of the predicted results. Emphasis will be placed on the organization of these concepts in a coherent, appropriately structured written format. Groups of approximately four students and two faculty instructors will meet for six tutorials during the course of the fall semester. Discussions will focus on the critical assessment of model research proposals and on the development of original proposals by individual students within the group.
Prerequisite: Core course in genetics, cell biology, molecular biology, and biochemistry.

*Genetics 331. Cell Cycle Checkpoints
Catalog Number: 2348
Tamar L. Enoch (Medical School) 3521

*Genetics 333. Molecular Biology of Neuronal Plasticity and Alzheimer’s Disease
Catalog Number: 6418
Rachael L. Neve (Medical School) 3525

*Genetics 335. Epigenetics, Chromatin, Gene Structure, and Evolution
Catalog Number: 4982
Chao-Ting Wu (Medical School) 3535

*Genetics 336. Developmental Biology of Hematopoiesis
Catalog Number: 7165
Leonard I. Zon (Medical School) 1137

*Genetics 337. Human Molecular Genetics
Catalog Number: 7194
Stuart H. Orkin (Medical School) 7402

*Genetics 339. Molecular Organ Development
Catalog Number: 3779
Mark C. Fishman (Medical School) 1170

*Genetics 340. Iron Metabolism in Red Blood Cells
Catalog Number: 2936
Nancy Andrews (Medical School) 1589

*Genetics 341. Anti-Tumor Immunity and Gene Transfer
Catalog Number: 3599
Glenn Dranoff (Medical School) 1821

*Genetics 343. Axis Establishment in Early Vertebrate Embryogenesis
Catalog Number: 5304
Jeremy Green (Medical School) 1950

*Genetics 344. Control of Gene Expression in Phagocytes and Injured Tissue
Catalog Number: 5739
Ellis J. Neufeld (Medical School) 1951

*Genetics 345. Chromosomal Stability and Inherited Disorders
Catalog Number: 4847
Hagop Youssoufian (Medical School) 2104

*Genetics 346. Molecular and Cell Biology of Serpins
Catalog Number: 5323
Gary A. Silverman (Medical School) 2086

*Genetics 347. Genetics of Host Resistance to Infectious Disease
Catalog Number: 5635
William F. Dietrich (Medical School) 2067

*Genetics 348. Molecular Genetics of Human Leukemias
Catalog Number: 5908
D. Gary Gilliland (Medical School) 2068

*Genetics 349. Signal Transduction in Disease and Development
Catalog Number: 0177
Andre Bernards (Medical School) 1824

*Genetics 350. Molecular Genetic Control of Mammalian Organogenesis
Catalog Number: 4974
Richard L. Maas (Medical School) 3703

*Genetics 351. Using Drosophila as a Genetic System to Study Signal Transduction Pathways
Catalog Number: 4998
Lizabeth A. Perkins (Medical School) 1604

*Genetics 352. Genetic and Molecular Approaches to Study Photoreceptor Cell Differentiation in the Drosophila Eye
Catalog Number: 5055
Iswar K. Hariharan (Medical School) 1796

*Genetics 355. Molecular Genetics of Human Neuromuscular Diseases
Catalog Number: 9253
Alan H. Beggs (Medical School) 1422

*Genetics 356. Hematopoiesis and Signal Transduction in Drosophila
Catalog Number: 4608
Charles R. Dearolf (Medical School) 3251

*Genetics 357. Search for Genes Causing Hereditary Diseases of the Retina
Catalog Number: 9953
Thaddeus P. Dryja, Jr. (Medical School) 2780

*Genetics 358. Mammalian Embryonic Patterning
Catalog Number: 8297
Susan M. Dymecki (Medical School) 1736

*Genetics 360. Genomic Imprinting and Gene Expression
Catalog Number: 6684
Marc E. Lalande (Medical School) 2503

*Genetics 361. Mechanism of X-inactivation in Mammals
Catalog Number: 9152
Jeannie T. Lee (Medical School) 2129

*Genetics 362. Molecular Biology and Genetics of Cancer
Catalog Number: 9382
David M. Livingston (Medical School) 4872

*Genetics 363. Neurogenesis in the Vertebrate Eye
Catalog Number: 8658
Jarema Malicki (Medical School) 2202

*Genetics 364. Development Application of Mammalian Vectors
Catalog Number: 7930
Richard C. Mulligan (Medical School) 2274

*Genetics 365. Genetic Imprinting and Human Disease
Catalog Number: 0451
Joseph Wagstaff (Medical School) 2634

*Genetics 366. Molecular Genetic Approaches to Human Disease Mechanisms
Catalog Number: 8153
Marcy E. MacDonald (Medical School) 2635

*Genetics 367. Mechanisms Governing Normal Cell Growth, Cancer and Aging
Catalog Number: 2500
Ronald A. DePinho (Medical School) 2637

*Genetics 368. Molecular & Genetic Mechanisms Responsible for Muscle Differentiation During Embryonic Development
Catalog Number: 7490
Alan M. Michelson (Medical School) 2029

*Genetics 369. Elucidating the Molecular Mechanisms Underlying Signal Transduction Pathways that Mediate Plant Responses to Central Growth Regulators, such as Sugars, Stress, and Phytohormones
Catalog Number: 3010
Jen Sheen

*Genetics 370. Molecular Genetics of the Ductal Carcinoma of Insitu of the Breast
Catalog Number: 4519
Kornelia Polyak (Medical School)

*Genetics 371. Functional Genomics and Proteomics of Signal Transduction
Catalog Number: 2190
Marc Vidal

Immunology


All courses in Immunology are subject to limitation in enrollment and will not be offered unless there is sufficient demand.

Primarily for Graduates

Immunology 200. Lymphocyte Development and the Generation of Diversity
Catalog Number: 2669
Shiv S. Pillai (Medical School), Frederick W. Alt (Medical School), Laurie H. Glimcher (Public Health), and Marjorie A. Oettinger (Medical School)
Half course (spring term). F., 3–5:30.
Topics discussed will include commitment to the lymphoid lineage, cell fate decisions in B and T cell development, the transcriptional regulation of lymphocyte development, the generation of TH1 and TH2 cells, and apoptotic death in the immune system. We will also examine the processes of VDJ recombination, isotype switching, and somatic mutation in mechanistic detail. The two parts of this course may be taken together as a half course, or individually as quarter courses which will be offered sequentially, one on DNA rearrangement and the other on lymphocyte development.
Note: The quarter courses are offered under Immunology 300. Offered jointly with the Medical School as IM 700.0. Given in alternate years.
Prerequisite: Genetics or Introductory Immunology course at the undergraduate or graduate level.

*Immunology 201. Principles of Immunology
Catalog Number: 8337
Hidde Ploegh (Medical School), Frederick W. Alt (Medical School) and Diane Mathis (Medical School)
Half course (fall term). Tu., Th., at 1:30. EXAM GROUP: 15, 16
As a comprehensive core course in immunology, the topics include a broad but intensive examination of the cells and molecules of the immune system. Special attention is given to the experimental approaches that led to the general principles of immunology.
Note: Background in genetics and biochemistry is strongly recommended. Offered jointly with the Medical School as IM 702.0.
Prerequisite: This course is intended for students who have had prior exposure to immunology on the undergraduate level. In the absence of such exposure, students MUST obtain the permission of the Course Director.

Immunology 205. Principles of Clinical Immunology
Catalog Number: 7604
Roy J. Soberman (Medical School), Richard L. Stevens (Medical School) and associates
Half course (spring term). Hours to be arranged.
Focuses on the molecular mechanism of immunologic diseases. A detailed examination of the current scientific literature and experimental approaches used to elucidate the mechanisms of these diseases is the subject of a combination of discussions and brief introductory lectures.
Note: Given in alternate years. Offered jointly with the Medical School as IM 707.0.
Prerequisite: General immunology and a strong knowledge of biochemistry is suggested.

[Immunology 217. Signal Transduction and Gene Regulation in the Immune System]
Catalog Number: 8205 Enrollment: Limited to 16.
Anjana Rao (Medical School), Hamid Band (Medical School), Michael Pazin (Medical School), and Brian Seed (Medical School)
Half course (spring term). Th., 4–6:30.
An advanced discussion of the mechanisms of signal transduction and inducible gene expression in cells of the immune system, with reference to non-immune cells types and systems. The two parts of this course are offered in sequence as individual quarter courses, the first on cell signaling and the second on transcriptional regulation. They may also be taken together as semester-long half course. The topics to be discussed include: protein modules and protein-protein interactions; antigen and coreceptor stimulatory pathways; adhesion receptors and lymphocyte homing; negative signaling and tolerance; viral subversion of the immune response; calcium signaling; MAP kinase cascades; cell activation and cell death; cytokine signalling; NFkB; cooperative mechanism in gene transcription; histone acetylation and DNA methylation; chromatin; locus control; and new approaches to the study of immune system function in vivo.
Note: Expected to be given in 2001–02. Given in alternate years. Offered jointly with the Medical School as IM 727.0.
Prerequisite: General biochemistry and immunology.

*Immunology 219. Immunodeficiencies and Infectious Diseases
Catalog Number: 1873
Cox Terhorst (Medical School), Michael B. Brenner (Medical School), Raif S. Geha (Medical School), Norman Letvin (Medical School), Fred S. Rosen (Medical School), and Michael Starnbach (Medical School)
Half course (spring term). M., 4–6:30.
This course will be divided into two parts. The first quarter describes genetically determined human immunodeficiency patients, murine immunodeficiencies caused by homologous recombination or introduction of transgenes, and human and animal acquired immunodeficiencies. Examines impact of defects on lymphoid differentiation and on immune responses. Evaluates use of animal models for study and therapy of human disease states. The second quarter characterizes natural host immune responses that contain infectious agents. Interactions between HIV and cells of the immune system will be emphasized. The two parts of this course can be taken together as a half course, or individually as a quarter course under Immunology 300.
Note: Given in alternate years. Offered jointly with the Medical School as IM 729.0.
Prerequisite: Course in basic immunology.

Graduate Courses of Reading and Research

Primarily designed for work on a thesis problem, carried out under the supervision of the following faculty members whose special research interests are listed.
*Immunology 300. Advanced Topics in Immunology
Catalog Number: 4739
Hidde Ploegh (Medical School) 3143
A series of reading and discussion seminars each running for a half semester (7 weeks). Two seminars, which can be taken in different semesters, are required for credit. Topics include the role of intracellular and transmembrane protein phosphates in signal transduction.
Note: Designed primarily for first- and second-year Immunology graduate students. Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0605 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.

*Immunology 301. Immunology Seminar
Catalog Number: 4971
Hidde Ploegh (Medical School) 3143
Half course (fall term; repeated spring term). W., 3:30–6:15.
Gives students exposure to research topics in Immunology. Students prepare for the weekly seminar through readings and occasional discussion with the seminar speakers. These discussions are facilitated by members of the Committee on Immunology.
Note: Designed primarily for first- and second-year Immunology graduate students.

*Immunology 302. Molecular Basis of Humoral Immunologic Inflammation
Catalog Number: 1355
K. Frank Austen (Medical School) 1571

*Immunology 304. Immediate Hypersensitive Reactions
Catalog Number: 2259
Kurt J. Bloch (Medical School) 3589

*Immunology 305. Mechanism of Delayed Hypersensitivity
Catalog Number: 2036
John R. David 3592

*Immunology 306. Immunochemical Aspects of Immune Reactions
Catalog Number: 1536
Stuart F. Schlossman (Medical School) 3593

*Immunology 307. Immunobiology of Transplantation
Catalog Number: 1609
Charles B. Carpenter (Medical School) 2016

*Immunology 308. Gene Regulation in the Immune Response
Catalog Number: 6895
Anjana Rao (Medical School) 1854

*Immunology 309. Molecular Aspects of Lymphocyte Interactions
Catalog Number: 3778
Cox Terhorst (Medical School) 6280

*Immunology 310. Molecular and Developmental Immunology
Catalog Number: 0217
Leslie J. Berg 2573

*Immunology 311. Defects in the Immune Response
Catalog Number: 2738
Fred S. Rosen (Medical School) 3595

*Immunology 312. Mechanisms of T-cell Homing
Catalog Number: 7968
Christina M. Parker (Medical School) 3024

*Immunology 314. Immunobiology of Antigen-Antibody Complexes
Catalog Number: 8065
Peter H. Schur (Medical School) 4551

*Immunology 315. Immunoregulation
Catalog Number: 5540
Martin E. Dorf (Medical School) 4541

*Immunology 316. Molecular Basis of Immunologic Recognition and Communication
Catalog Number: 3192
Harvey Cantor (Medical School) 4460

*Immunology 317. Molecular Biology of Receptor Transduction in the Immune System
Catalog Number: 0518
Brian Seed (Medical School) 7619

*Immunology 319. Molecular Biology of Immune Cell Interactions
Catalog Number: 0293
Timothy A. Springer (Medical School) 6145

*Immunology 320. Biology of Parasitism
Catalog Number: 2870
John R. David 3592

*Immunology 321. Studies of T-Cell Activation
Catalog Number: 5008
Steven J. Burakoff (Medical School) 1348

*Immunology 323. Research in Molecular Immunology
Catalog Number: 3425
Laurie H. Glimcher (Public Health) 1362

*Immunology 325. Molecular Genetics of the Immune System
Catalog Number: 3182
Jonathan G. Seidman (Medical School) 7529

*Immunology 326. Molecular and Cellular Human Immunobiology
Catalog Number: 6719
Ellis L. Reinherz (Medical School) 1408

*Immunology 327. Chemical Cell Biology
Catalog Number: 0824
Stuart L. Schreiber 2166

*Immunology 328r (formerly Immunology 328). Introduction to Research
Catalog Number: 5531
Hidde Ploegh (Medical School) 3143

*Immunology 329. Basic and Clinical Mechanisms of Autoimmunity
Catalog Number: 0354
Howard L. Weiner (Medical School) 1335

*Immunology 330. Molecular Aspects of Mast Cells—Mediated Immune Responses
Catalog Number: 7296
Richard L. Stevens (Medical School) 2892

*Immunology 333. Immunopathogenesis of Viral Diseases
Catalog Number: 2430
Norman Letvin (Medical School) 2317

*Immunology 334. Molecular Aspects of Immunoregulation and T-Cell Activation
Catalog Number: 0492
Christopher E. Rudd (Medical School) 2310

*Immunology 335. T-Cell Receptor Interactions in Autoimmune Diseases
Catalog Number: 4027
David Hafler (Medical School) 2616

*Immunology 336. T-Lymphocyte Recognition and Adhesion
Catalog Number: 7292
Michael B. Brenner (Medical School) 2864

*Immunology 337. Development of Mucosal Immmunologic Factor
Catalog Number: 1320
W. Allan Walker (Medical School) 1175

*Immunology 338. Signal Transduction in the Immune System
Catalog Number: 5458
Hamid Band (Medical School) 2867

*Immunology 339. Function and Regulation of Cellular Adhesion Mechanisms
Catalog Number: 7841
Martin E. Hemler (Medical School) 2868

*Immunology 340. The Human Major Histocompatibility Complex, Immune Function, and Disease
Catalog Number: 6650
Chester Alper (Medical School) 2951

*Immunology 342. The Platelet Membrane Skeleton
Catalog Number: 4154
Thomas P. Stossel (Medical School) 7734

*Immunology 344. Genetic Analysis of Lymphocyte Development and Nuclear Oncogene Function
Catalog Number: 6438
Frederick W. Alt (Medical School) 3146

*Immunology 345. Assembly and Function of pre-B Cell-fate and B Lymphocyte Antigen Receptors
Catalog Number: 0866
Shiv S. Pillai (Medical School) 3393

*Immunology 346. The Role of Complement in the Immune Response
Catalog Number: 1755
Michael C. Carroll (Medical School) 2050

*Immunology 348. Cell Biology, Biochemistry, and Immunology of Leukocyte-endothelial Adhesion
Catalog Number: 0901
Francis W. Luscinskas (Medical School) 3772

*Immunology 349. Mechanisms of T Cell and NK Cell Tolerance
Catalog Number: 1241
Megan Sykes (Medical School) 1131

*Immunology 350. Regulation of Autoimmune T Cell Responses
Catalog Number: 1916
Vijay K. Kuchroo (Medical School) 2041

*Immunology 353. Topics in Reproductive Immunology
Catalog Number: 7219
Deborah J. Anderson (Medical School) 2611

*Immunology 354. Topics in Transplantation Biology
Catalog Number: 1459
David H. Sachs (Medical School) 1075

*Immunology 355. Biochemistry of MHC Class I- and MHC Class II-restricted Antigen Presentation
Catalog Number: 7338
Hidde Ploegh (Medical School) 3143

*Immunology 356. Cytotoxic T Lymphocytes
Catalog Number: 8232
Judy Lieberman (Medical School) 1542

*Immunology 357. T Cell-Epithelial Cell Interactions in Mucosal Community
Catalog Number: 2111
Richard S. Blumberg (Medical School) 2351

*Immunology 358. Mechanisms of Gene Activation
Catalog Number: 0965
Santa Jeremy Ono (Medical School) 3284

*Immunology 359. Discovery of New Pathways for Antigen Presentation of T Lymphocytes & of New Classes of Antigens that are Targeted by the Cell-mediated Immune Response
Catalog Number: 9299
Steven Anthony Porcelli (Medical School) 2886

*Immunology 360. Focus on the Hematopoietic Stem Cell in the Context of AIDS and Cancer
Catalog Number: 8952
David T. Scadden (Medical School) 2649

*Immunology 361. Induction and regulation of antigen-specific T cell responses
Catalog Number: 7578
Gilles A. Benichou (Medical School) 2652

*Immunology 362. Basic Biology and Pathobiology of the Chemokine Superfamily of Cytokines
Catalog Number: 3817
Andrew D. Luster (Medical School) 2654

*Immunology 363. Regulation of Mast Cell Activation
Catalog Number: 6813
Howard R. Katz (Medical School) 2837

*Immunology 364. T-Cell Development in Animal Models of Autoimmunity Disease
Catalog Number: 0972
Diane J. Mathis (Medical School) 3063

*Immunology 365. Mucosal T Cell Mediated Immunity and Tolerance
Catalog Number: 4204
Cathryn R. Nagler-Anderson (Medical School) 1022

*Immunology 366. Molecular Regulation of T Cell Cytokine Production and T Cell Interactions
Catalog Number: 6676
Andrew H. Lichtman (Medical School) 3523

*Immunology 367. Biology and Chemistry of Complement Problems
Catalog Number: 8080
Anne Nicholson-Weller (Medical School) 1063

*Immunology 368. Apoptosis and Autoimmunity
Catalog Number: 8986
Paul J. Anderson (Medical School) 1947

*Immunology 369. Mechanisms of Autoimmune Disease
Catalog Number: 6787
Vicki R. Kelley (Medical School) 2656

*Immunology 370. Cell Cycle Checkpoints, Gene Rearrangements, DNA Repair
Catalog Number: 1816
Gary A. Rathbun (Medical School) 3774

*Immunology 371. Cellular and Molecular Mechanisms of Eosinophil in Allergic Flammation
Catalog Number: 3716
Peter F. Weller (Medical School) 2657

*Immunology 372. Mechanisms Graft Rejection: Allo and Xeno
Catalog Number: 3207
Hugh Auchincloss (Medical School) 2661

*Immunology 373. Biology of Histocompatibility Systems; Immunology of Aging
Catalog Number: 6317
Edmund J. Yunis (Medical School) 6036

*Immunology 374. Tumor Necrosis Factor-Alpha Gene Regulation in the Immunopathogenesis of AIDS and TB
Catalog Number: 4558
Anne E. Goldfeld (Medical School) 1008

*Immunology 375. Biology and Function of Immunoreceptors
Catalog Number: 0510
Jean-Pierre Kinet (Medical School) 2663

*Immunology 376. Regulation of IgE Reponses; Molecular Basis of Immunodeficienies
Catalog Number: 3618
Raif S. Geha (Medical School) 1795

*Immunology 377. Regulation of T Helper Cell Differentiation
Catalog Number: 0458
Michael Grusby (Medical School) 1987

*Immunology 378. Basic Mechanisms of T cell Mediated Autoimmune Diseases
Catalog Number: 2916
Kai Wucherpfennig (Medical School) 2481

*Immunology 379. Induction of Immunological Tolerance by Gene Therapy
Catalog Number: 9300
John J. Iacomini (Medical School) 2643

*Immunology 380. Control of Leukocyte Trafficking and the Immune Response By Chemokines and Other Cytokines
Catalog Number: 4872
Barrett J. Rollins (Medical School) 3775

*Immunology 381. Lymphocyte Development, Signaling, Immuneregulation
Catalog Number: 0839
Harald Von Boehmer (Medical School) 3302

*Immunology 382. AIDS Immunopathogenesis and Immune Reconstitution
Catalog Number: 0468
Robert P. Johnson (Medical School) 6125

*Immunology 383. Translational Approaches In Transplantation and Tumor Immunity
Catalog Number: 4590
Lee M. Nadler (Medical School) 3773

*Immunology 399. Topics in Immunology
Catalog Number: 2377
Hidde Ploegh (Medical School) 3143

Medical Sciences

Primarily for Graduates

*Medical Sciences 215 (formerly Physiology 102). Integrated Human Physiology
Catalog Number: 6359
Bruce R. Zetter (Medical School) and members of the Faculty
Half course (fall term). M., through F., 8:30–12:00.
This course describes the physiological mechanisms underlying the functions and interactions of the major systems of the human body, including the cardiovascular, renal, gastrointestinal, respiratory, endocrine, and reproductive systems. Particular emphasis is placed on the interactions between these systems and the overall integration of physiological functions. The course is geared primarily toward small group exercises including case discussions, problem sets, hospital based demonstrations, and laboratories.
Note: Offered jointly with the Medical School as IN 712.0. Course begins on December 14 and concludes with an exam on February 7. Students taking the course for credit are expected to attend all course sessions. Permission of both the course director and the Medical School Registrar is required.

*Medical Sciences 250ab. Human Functional Anatomy
Catalog Number: 6946 Enrollment: Limited to 48. Minimum 25; maximum 48.
Farish A. Jenkins, Jr., Lee Gehrke (Medical School), and Samuel Kennedy (Medical School)
Full course (fall term). Lectures, M., W., F., 1:30–2:30; laboratory, M., W., F., 2:30–6.
Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of bioengineering are employed to promote analytical approaches to understanding the body’s design. The embryology of major organ systems presented, together with certain references to phylogenetic development, as a basis for comprehending anatomical complexity. Correlation clinics stress both normal and abnormal functions of the body; guest lectures focus on current problems in organ system research and molecular aspects of development.
Note: Open to qualified graduate students with permission of the instructors. Undergraduates are ordinarily not admitted to the course, although occasional exceptions may be made for those with a clearly defined interest in anatomy other than for pre-medical preparation. The course is not open to undergraduates planning a postgraduate career in medicine. Begins September 6, 2000. Students must register with instructors before first meeting of course (495-2499). Offered jointly with the Medical School as HT 010.

Medical Sciences 265. Human Physiology: Classical and Contemporary Approaches
Catalog Number: 4308
Edmund A. Mroz, Jr. (Medical School)
Half course (spring term). Hours to be arranged.
Explores function of the human organism, through experimental findings and underlying principles of classical physiology and of cellular and molecular biology. Covers the cardiovascular, respiratory, renal, and gastrointestinal systems, and energy metabolism. Discusses cellular and molecular basis of function while emphasizing integrated regulation via endocrine and autonomic nervous systems.
Note: Contact instructor: E-mail eam@epl.meei.harvard.edu Tel:573-4232. Offered jointly with the Medical School as MS 701.0.
Prerequisite: Cell biology or biochemistry.

Graduate Courses of Reading and Research

*Medical Sciences 300. Conduct of Science
Catalog Number: 1815
Thomas O. Fox (Medical School) 4542

*Medical Sciences 399. Topics in Medical Sciences
Catalog Number: 3197
Thomas O. Fox (Medical School) 4542
Subject selected by students and faculty member.

Microbiology and Molecular Genetics


All courses in Microbiology and Molecular Genetics are subject to limitation in enrollment and will not be offered unless there is sufficient demand.

Primarily for Graduates

*Microbiology 200. Molecular Microbiology and Pathogenesis
Catalog Number: 7773
Catherine A. Lee (Medical School), R. John Collier (Medical School), Dan G. Fraenkel (Medical School), and Roberto G. Kolter (Medical School)
Half course (spring term). M., W., F., 9–10:30. Pre-class meeting 1/30/01.
Course will be devoted primarily to bacterial structure, physiology, genetics, regulatory mechanisms and pathogenesis. Class time will consist of a combination of: 1) lecture, 2) presentations emphasizing methods, results and interpretation of classic and contemporary literature, 3) guest seminars, and 4) small group discussions of papers.
Note: Offered jointly with the Medical School as MG 726.0.

*Microbiology 205. Mechanisms of Microbial Pathogenesis
Catalog Number: 2480 Enrollment: Limited.
Clyde S. Crumpacker II (Medical School), Harvey B. Simon (Medical School) and associates
Half course (fall term). Tu., Th., 8:30–1.
The mechanisms of bacterial, mycoplasmal, fungal, and viral pathogenesis are covered. Topics are selected for intrinsic interest and cover the spectrum of pathophysiologic mechanisms of the infectious process. Emphasis on pathogenesis at the molecular level.
Note: Offered jointly with the Medical School as HT 040.

Microbiology 209. Molecular Biology of Bacterial Development and Multicellularity
Catalog Number: 2698 Enrollment: Limited to 12. Limited to 12.
Roberto G. Kolter (Medical School) and associates
Half course (spring term). Tu., 1–4.
The course provides an in depth coverage of bacterial systems displaying complex developmental processes and intercellular communication. A major aim of the course is to give students experience in researching topics and preparing formal lecture presentations. Lectures are accompanied by critical discussions of key papers. The specific topics vary from year to year and are selected based on the recent literature and student interest.
Note: Given in alternate years. A minimum of 8 interested students are required to offer the course, open to graduate and advanced undergraduate students. Contact the instructor at 432-1776. Offered jointly with the Medical School as MG 727.0.

*Microbiology 212. Bacterial Metabolism
Catalog Number: 0598
Dan G. Fraenkel (Medical School)
Half course (fall term). Th., 2–5.
Pathways and energy metabolism. A discussion course based on papers.
Note: Contact the instructor at 432-1912. Offered jointly with the Medical School as MG 728.0.

[Microbiology 213. Social Issues in Biology]
Catalog Number: 7905
Jonathan R. Beckwith (Medical School), Roberto G. Kolter (Medical School), Louis Guenin (Medical School) and Sheila S. Jasanoff (Kennedy School)
Half course (spring term). Th., 1–4.
A series of presentations and discussions on several of the following: philosophy, history, and sociology of science, science and journalism, genetics and the law, fraud in science, social and ethical issues in genetic screening, genes and human behavior, gender issues in biology, and the Human Genome Project. A set of readings is prepared for each session that includes differing viewpoints on the topic at hand.
Note: Expected to be given in 2001–02. Given in alternate years. Offered jointly with the Medical School as MG 722.0.
Prerequisite: Some background in genetics.

Microbiology 230. Analysis of the Biological Literature
Catalog Number: 3791 Enrollment: Limited to and required of all first-year BBS students.
Anindya Dutta (Medical School), Stephen C. Blacklow (Medical School), Elaine A. Elion (Medical School), Grace Gill (Medical School), Andrius Kazlauskas (Medical School), Andrea I. McClatchey (Medical School), Karl Münger (Medical School), Jeffrey D. Parvin (Medical School), David Pellman (Medical School), Piotr Sicinski (Medical School), and Sheila Thomas (Medical School)
Half course (fall term). Tu., Th., 6–9 p.m.
Critical analysis of original research articles in an intensive small group discussion format. Papers will be analyzed in terms of background, hypothesis, appropriate use of experimental methods, and objective interpretation of results. Covers a wide range of papers in biochemistry, genetics, microbiology, and cell and developmental biology.

Graduate Courses of Reading and Research

Primarily designed for work on a thesis problem, carried out under the supervision of the following faculty members, whose special research interests are listed. Courses in parasitology are listed in the catalog of the Harvard School of Public Health (see Pathology).
*Microbiology 300. Advanced Topics in Microbiology and Molecular Genetics
Catalog Number: 2304
Michael Starnbach (Medical School) 1816
A series of reading and discussion seminars, each running for a half semester (7 weeks). Two seminars, which can be taken in different semesters, are required for credit.
Note: Non-DMS students must get permission from the Division of Medical Sciences before registering for this course. Please contact us at 432-0605 or visit the DMS Office at T-MEC 435, 260 Longwood Avenue, Boston.
Prerequisite: Dependent on seminar.

*Microbiology 303. Transcription Regulation During Mammalian Embryogenesis
Catalog Number: 4112
Mary R. Loeken (Medical School) 3151

*Microbiology 305. Molecular Determinants of Intracellular Bacterial Pathogenesis
Catalog Number: 3190
Darren E. Higgins (Medical School) 2963

*Microbiology 306. Molecular Basis for Simian Virus Pathogenesis
Catalog Number: 3185
Ronald C. Desrosiers (Medical School) 1874

*Microbiology 307. Growth Factors and Signal Transduction
Catalog Number: 5726
Charles D. Stiles (Medical School) 4828

*Microbiology 308. Infectious Disease & Basic Microbiological Mechanims
Catalog Number: 4217
Dennis L. Kasper (Medical School) 4815

*Microbiology 309. Microbial Metabolism
Catalog Number: 5086
Dan G. Fraenkel (Medical School) 1169

*Microbiology 311. Bacterial Genetics
Catalog Number: 7402
Jonathan R. Beckwith (Medical School) 1173

*Microbiology 313. T-Lymphocyte Responses to Bacterial Pathogens
Catalog Number: 4959
Michael Starnbach (Medical School) 1816

*Microbiology 314. Cell Interactions in Vertebrate Development
Catalog Number: 0862
Sergei Y. Sokol (Medical School) 3530

*Microbiology 315. Biochemical Mechanisms Controlling Cell Growth and Differentiation
Catalog Number: 3273
Michael E. Greenberg (Medical School) 1400

*Microbiology 317. Molecular Mechanisms in Pathogenesis
Catalog Number: 8985
John J. Mekalanos (Medical School) 7315

*Microbiology 318. RNA Structure, RNA-protein Interactions, and Translation-level Gene Regulation in RNA Viruses
Catalog Number: 1205
Lee Gehrke (Medical School) 8036

*Microbiology 319. Regulation of Gene Expression and Evolution of Metabolic Pathways in Bacteria
Catalog Number: 1168
Edmund C. C. Lin (Medical School) 1183

*Microbiology 320. Molecular Biology of Herpes Viruses
Catalog Number: 3967
David M. Knipe (Medical School) 7089

*Microbiology 321. Molecular Biology of Bacterial Interactions
Catalog Number: 2903
Roberto G. Kolter (Medical School) 7727

*Microbiology 322. Biochemistry of Bacterial Toxins
Catalog Number: 4970
R. John Collier (Medical School) 7972

*Microbiology 323. Molecular Genetic Analysis of Virulence Factors in Gram-Negative Pathogens and Construction of Recombinant Vaccines
Catalog Number: 4931
Stephen Calderwood (Medical School) 3520

*Microbiology 324. Bacterial Pathogenesis, Vaccine Development & Host Epithelial Cell Responses to Bacterial Infection
Catalog Number: 3472
Gerald Pier (Medical School) 2853

*Microbiology 326. Protein-Protein Interactions in Eukaryotic Signal Transduction
Catalog Number: 1582
Bruce J. Mayer (Medical School) 1638

*Microbiology 328. Molecular Biology of Epstein Barr Virus Infection and Transformation of B Lymphocytes
Catalog Number: 3188
Elliott D. Kieff (Medical School) 1858

*Microbiology 332. Gene Regulation of Prokaryotes
Catalog Number: 0915
Ann Hochschild (Medical School) 2314

*Microbiology 333. Bacterial Pathogenesis
Catalog Number: 4275
Catherine A. Lee (Medical School) 3259

*Microbiology 335. Molecular Biology of Parasites
Catalog Number: 0528
Dyann F. Wirth (Medical School, Public Health) 2492

*Microbiology 336. Pathogen-host Interactions
Catalog Number: 3981
Marcia Goldberg (Medical School) 3783

*Microbiology 338. Structure-Function of Human Mannose-Binding Protein
Catalog Number: 4424
R. Alan Ezekowitz (Medical School) 1808

*Microbiology 340. Herpes Virus Transformation and Gene Transfer Vector
Catalog Number: 8544
Jae Ung Jung (Medical School) 2048

*Microbiology 341. DNA Recombination and Repair in Mammalian Cells
Catalog Number: 6153
David T. Weaver (Medical School) 2031

*Microbiology 342. Reovirus Structure, Assembly, and Particle Functions in Entry and RNA Synthesis
Catalog Number: 4181
Max Nibert

Neurobiology

Primarily for Graduates

Neurobiology 200. Introduction to Neurobiology
Catalog Number: 6062 Enrollment: Limited to 45. Limited to 45.
Richard H. Masland (Medical School), John A. Assad (Medical School), David P. Corey (Medical School), Bradley T. Hyman (Medical School), David N. Louis (Medical School), and guest lecturers
Half course (fall term). M., W., F., 9–12.
Spans modern neuroscience from molecular neurobiology to perception and cognition, including the following major topics: anatomy and development of the brain; cell biology of neurons and glia; ion channels and electrical signaling; synaptic transmission, integration, and chemical systems of the brain; sensory systems; motor systems; higher brain function (memory, language, affective disorders).
Note: Offered jointly with the Medical School as HT 130. Follows the Medical School calendar. Three hours of lecture and six hours of lecture/conference weekly.

Neurobiology 204. Neurophysiology of Central Circuits
Catalog Number: 5603
R. Clay Reid (Medical School), John A. Assad (Medical School), Stephen C. Cannon (Medical School), and Associates
Half course (spring term). M., W., 10–12.
Introduction to the physiology of circuits in the vertebrate central nervous system. Topics include the auditory, somatosensory, and visual systems, the cerebellum, and the neural control of eye movements. The behavior of these systems will be analyzed at three levels: the electrophysiological properties of single neurons, synaptic interactions between neurons in vitro, and the behavior of the circuits in vivo.
Note: Offered jointly with the Medical School as NB 721.0.
Prerequisite: Neurobiology 220.

[Neurobiology 205. Neurobiology of Developmental Disabilities]
Catalog Number: 4236 Enrollment: Minimum of 10.
Ursula C. Dräger (Medical School), Gerald Frank Cox (Medical School), and Peter McCaffery (Medical School)
Half course (spring term). Hours to be arranged.
In-depth study of the neurochemical basis of developmental disabilities, especially those leading to mental retardation. Emphasis on cell and molecular biological processes underlying abnormalities associated with brain structure and function. Topics include neuroanatomical abnormalities, molecular genetics of developmental disorders, teratology, enzymopathies, demyelinating disorders, nutritional effects on brain, neuroendocrine control mechanisms, and behavior.
Note: Expected to be given in 2001–02. Given in alternate years. Offered jointly with the Medical School as NB 717.0.
Prerequisite: Introductory neurobiology and biochemistry.

[Neurobiology 206. Neuropharmacology]
Catalog Number: 1733
Jonathan B. Cohen (Medical School), Kathleen M. Buckley (Medical School), and Morgan H. Sheng (Medical School)
Half course (spring term). Tu., Th., 9:30–11.
Introduction to the pharmacology of synaptic function, receptor recognition, and regulation. Topics include the structure and function of neurotransmitter receptors and their intracellular signalling pathways, and the mechanisms involved in the metabolism, storage, and release of neurotransmitters. Examples are chosen from monoamine, amino acid, and peptidergic systems to illustrate the molecular basis of neuropharmacology.
Note: Expected to be given in 2001–02. Given in alternate years. Offered jointly with the Medical School as NB 718.0.
Prerequisite: Knowledge of introductory biochemistry and neurobiology.

Neurobiology 207. Developmental Neurobiology
Catalog Number: 4977 Enrollment: Limited to 30. Limited to 30.
Rosalind A. Segal (Medical School), Stuart A. Tobet (Medical School), David L. Van Vactor (Medical School), and Christopher A. Walsh (Medical School)
Half course (spring term). Tu., Th., 3–5.
Development of the nervous system. Topics include delineation of neural vs. non-neural tissues; axial and segmental patterning; cell lineage; specification of neuronal identity; axonal outgrowth and guidance; synapse formation and regression; hormonal influences on nervous system development.
Note: Given in alternate years. Offered jointly with the Medical School as NB 720.0.
Prerequisite: *Neurobiology 300 or permission of instructor.

[Neurobiology 209. The Neurobiology of Disease]
Catalog Number: 5562
Edward A. Kravitz (Medical School), Robert H. Brown (Medical School), and Walter J. Koroshetz (Medical School)
Half course (spring term). Hours to be arranged.
Designed for advanced undergraduate and graduate students interested in diseases and disorders of the nervous