Chemistry and Chemical Biology

Faculty of the Department of Chemistry and Chemical Biology

James G. Anderson, Philip S. Weld Professor of Atmospheric Chemistry (Chair) (on leave fall term)
James E. Davis, Senior Lecturer on Chemistry and Chemical Biology and Molecular and Cellular Biology (Head Tutor)
David A. Evans, Abbott and James Lawrence Professor of Chemistry
Bretislav Friedrich, Lecturer on Chemistry and Chemical Biology
Cynthia M. Friend, Theodore William Richards Professor of Chemistry (on leave spring term)
Roy G. Gordon, Thomas Dudley Cabot Professor of Chemistry
Eric J. Heller, Professor of Chemistry and Physics
Dudley R. Herschbach, Frank B. Baird, Jr. Professor of Science (on leave spring term)
Richard H. Holm, Higgins Professor of Chemistry
Eric N. Jacobsen, Harvard College Professor and the Sheldon Emery Professor of Chemistry
William Klemperer, Erving Professor of Chemistry
Jeremy R. Knowles, Amory Houghton Professor of Chemistry and Biochemistry and Dean of the Faculty of Arts and Sciences
Charles M. Lieber, Mark Hyman, Jr. Professor of Chemistry
David R. Liu, Assistant Professor of Chemistry and Chemical Biology
Andrew G. Myers, Professor of Chemistry and Chemical Biology
Hongkun Park, Assistant Professor of Chemistry and Chemical Biology
Garry Procter, Lecturer on Chemistry and Chemical Biology
David R. Reichman, Assistant Professor of Chemistry and Chemical Biology, Associate of Adams House
Stuart L. Schreiber, Morris Loeb Professor of Chemistry and Chemical Biology
Matthew D. Shair, Assistant Professor of Chemistry and Chemical Biology
Eugene I. Shakhnovich, Professor of Chemistry and Chemical Biology
Richard J. Staples, Lecturer on Chemistry and Chemical Biology
Gregory L. Verdine, Professor of Chemistry, Associate of Pforzheimer House
George M. Whitesides, Mallinckrodt Professor of Chemistry and Chemical Biology
Claude Wintner, Visiting Scholar in Chemistry and Chemical Biology, Visiting Professor of Chemistry and Chemical Biology (Haverford College)
Xiaoliang Sunney Xie, Professor of Chemistry and Chemical Biology

Affiliates of the Department

Stephen C. Harrison, Higgins Professor of Biochemistry and Molecular Biology
David R. Nelson, Mallinckrodt Professor of Physics and Professor of Applied Physics (on leave 2000-01)
Don C. Wiley, John L. Loeb Professor of Biochemistry and Biophysics, Tutor in Biochemical Sciences (on leave 2000-01)

Depending on their prior preparation, students will choose one of three possible entries to studies in this Department. Students with an average or weak background in chemistry should enroll in Chemistry 5 and 7; students with a strong background in chemistry should enroll in Chemistry 10; students with outstanding chemical preparation may enroll at once in Chemistry 17 or 20. Most well prepared students who wish to pursue honors level concentration in chemistry or closely allied fields will elect the (10)+20+30+40+135 track. Others who start with 5+7+17+27 may join the other track by taking 135 and 40. Most students of life sciences, especially those preparing for medical school, will take 5+7 or 10 followed by 17 and 27. Students may not take both Chemistry 17 and 20 for credit. Since there is little or no overlap in content between Chemistry 27 and 30, students interested in a strong background in both bio-organic and theoretical organic chemistry may take both courses. The Science A Core requirement may be satisfied by taking any one of Chemistry 5, 7, 10, 17, or 20.

Certain courses in biochemistry and biophysics are listed under Molecular and Cellular Biology or Biophysics (see cross-listings at end of middle group course section.) The Division of Engineering and Applied Sciences, the Department of Physics, and the Department of Earth and Planetary Sciences also list a number of courses of interest to chemists.

Primarily for Undergraduates

Because of the sequence of prerequisites for chemistry courses, the Department strongly recommends some work in mathematics as well as chemistry in the first year. Freshmen contemplating this program are urged to consult a member of the Chemistry Department in planning their work for the first year. Advice may be obtained in the Head Tutor’s Office, Science Center 114.
Chemistry 5. Introduction to Principles of Chemistry
Catalog Number: 7171
James E. Davis
Half course (fall term). M., W., F., at 9, one hour per week of discussion, and three hours per week of laboratory. EXAM GROUP: 2
Introduction to the structure and properties of atoms, molecules, and ions, stoichiometry; thermochemistry; electronic structure of atoms; periodic properties of the elements; chemical bonding; molecular geometry and bonding theories; gases; intermolecular forces, liquids, and solids; properties of solutions.
Note: Chemistry 5–7 is the mainstream general chemistry sequence for students with typical high school chemistry backgrounds (one year) or for students with no previous study of chemistry. Calculus is not necessary for Chemistry 5, but a strong background in high school algebra is essential. Students who lack this algebra background should take Math Ar or Math Xa before attempting Chemistry 5. Students with very strong high school chemistry backgrounds may enroll instead in Chemistry 10, 17, or 20; see those course descriptions for details.

Chemistry 7. Principles of Chemistry
Catalog Number: 5118
Roy G. Gordon and Charles M. Lieber
Half course (spring term). M., W., F., at 9, one hour per week of discussion, and three hours per week of laboratory. EXAM GROUP: 2
Evolution of the elements; nuclear chemistry; rates and mechanisms of chemical reactions; chemical kinetics; chemical equilibrium; acids and bases; additional aspects of aqueous equilibria; instrumental analysis; chemistry of the environment; chemical thermodynamics; electrochemistry; modern materials; chemistry of the nonmetals; metals and metallurgy; chemistry of coordination compounds; the chemistry of life.
Prerequisite: Chemistry 5 or equivalent, in particular: chemical equilibrium, the first and second law of thermodynamics, and elements of acid-base chemistry. A few simple operations of the calculus are developed and used. Fluency in precalculus secondary school mathematics is assumed. Exposure to secondary school physics will be helpful.

Chemistry 10. Accelerated Course: Foundations of Chemistry
Catalog Number: 1376
Dudley R. Herschbach and Eugene I. Shakhnovich
Half course (fall term). Lectures M., W., F., at 9, discussion section, and laboratory work averaging four hours a week, to be arranged. EXAM GROUP: 2
Physical principles in chemistry: atomic and molecular structure, thermodynamics, and chemical kinetics. Applications to reaction equilibria and mechanisms; electrochemistry; photochemistry; environmental chemistry, life sciences and materials chemistry; selected commonplace, exotic, and poetic phenomena. Laboratory work stresses the principles and techniques of quantitative chemistry.
Note: Open to students with strong secondary school courses in chemistry, physics and mathematics, and who are currently enrolled in Mathematics 1a (or equivalent preparation). To be admitted to Chemistry 10, students must obtain a satisfactory score on the Harvard Chemistry Placement Examination, given during freshman week, or must obtain permission of the instructor. Students who do not take this examination or do not achieve a satisfactory score should take Chemistry 5 and 7. Chemistry 10 may not be counted toward a degree in addition to Chemistry 5 or 7.

Chemistry 17. Principles of Organic Chemistry
Catalog Number: 5085
Claude Wintner (Haverford College)
Half course (fall term). M., W., F., at 11, and a discussion section to be arranged. EXAM GROUP: 4
An introduction to structure, bonding, and reaction mechanisms of organic compounds; chemical transformation of the common functional groups; principles of organic synthesis.
Note: The Chemistry 17/27 sequence is intended primarily for students in the life sciences, whereas the 20/30 sequence is intended primarily for Chemistry concentrators and other students concentrating in the physical sciences. Either sequence satisfies the organic chemistry requirement for medical school. The content of Chemistry 17 is similar to that of Chemistry 20, so students may not count both courses toward the degree. On the other hand, Chemistry 27 and Chemistry 30 cover different material, so students may choose to take both courses for degree credit; students should ordinarily take the third half course only after completing either the 17/27 or 20/30 sequence.
Prerequisite: Open to freshmen with a score of 750 or higher in the College Boards or the Chemistry Placement Examination; to students who scored 4 or 5 on the Chemistry Advanced Placement Examination; and to students who achieved a grade of B or higher in either Chemistry 7, or 10. Others may enter only by permission of the instructor.

Chemistry 20. Organic Chemistry
Catalog Number: 0876
Gregory L. Verdine
Half course (spring term). Lectures, M., W., F., at 9, and a discussion section to be arranged. EXAM GROUP: 2
An introduction to structure, bonding, and mechanism of organic reactions; chemical transformation of the common functional groups in aliphatic and aromatic compounds; synthesis; determination of structure; infrared and NMR spectroscopy.
Note: The Chemistry 17/27 sequence is intended primarily for students in the life sciences, whereas the 20/30 sequence is intended primarily for Chemistry concentrators and other students concentrating in the physical sciences. Either sequence satisfies the organic chemistry requirement for medical school. The content of Chemistry 17 is similar to that of Chemistry 20, so students may not count both courses toward the degree. On the other hand, Chemistry 27 and Chemistry 30 cover different material, so students may choose to take both courses for degree credit; students should ordinarily take the third half course only after completing either the 17/27 or 20/30 sequence.
Prerequisite: Open to freshmen with a score higher than 750 in the College Boards or the Chemistry Placement Examination; to students who scored 5 on the Chemistry Advanced Placement Examination; and to students who achieved a grade of B or higher in either Chemistry 7, 9, or 10. Others may enter only by permission of the instructor.

Chemistry 27. Organic Chemistry of Life
Catalog Number: 5978
Matthew D. Shair
Half course (spring term). M., W., F., at 11, and a discussion section, and a five hour laboratory each week to be arranged. EXAM GROUP: 4
Sequel to Chemistry 17. Organic chemical principles of molecular science that govern the processes occurring in living systems are illustrated with examples drawn from biochemistry, cell biology, and medicine. The course deals with generalities of organic chemical reactivity (reaction mechanisms, structure-reactivity and structure-property relationships), with matters specifically relevant to the life sciences (chemistry of proteins, nucleic acids, natural products, cofactors, signal transduction), and with applications of chemical biology in medicine and biotechnology (drug design and mechanism, metabolism). It requires an understanding of organic reactions and their mechanisms, with considerable focus on “arrow pushing”.
Note: Chemistry 27 and 30 may both be taken for degree credit. See note for Chemistry 17.
Prerequisite: Chemistry 17; Chemistry 30; or Chemistry 20 with permission of the instructor.

Chemistry 30. Organic Chemistry
Catalog Number: 6587
Eric N. Jacobsen
Half course (fall term). Lectures M., W., F., at 9, and laboratory, four to six hours a week, to be arranged. EXAM GROUP: 2
Continuation of Chemistry 20 including reactions involving carbanions, carbonium ions, carbenes and free radicals; and an introduction to biologically important classes of compounds including carbohydrates, amino acids, peptides, nucleic acids and other heterocyclic compounds. Laboratory: an introduction to the practice of organic chemistry and the identification of unknown compounds.
Note: Chemistry 27 and 30 may both be taken for dergee credit. See note for Chemistry 17.
Prerequisite: Chemistry 20 or Chemistry 27.

Chemistry 40. Inorganic Chemistry
Catalog Number: 8201
William Klemperer and Richard H. Holm
Half course (spring term). M., W., F., at 12. EXAM GROUP: 5
An introduction to basic concepts of inorganic chemistry. Topics include synthesis, bonding, thermodynamics, stereochemistry, and reactivity of inorganic compounds of the main group and the transition elements.
Prerequisite: Chemistry 17 or 20.

Chemistry 60. Foundations of Physical Chemistry
Catalog Number: 5181
Eric J. Heller
Half course (fall term). Tu., Th., 10–11:30. EXAM GROUP: 12, 13
This course is designed to be a compact introduction to major principles of physical chemistry (chemical kinetics, thermodynamics, and statistical mechanics), concurrently providing mathematical and physical foundations for these subjects and mathematical preparation for Chemistry 160 and 161, or Chemistry 105.
Prerequisite: Chemistry 5, 7 or 10 or equivalent; completion or concurrent enrollment in Mathematics 21a or Applied Mathematics 21a; completion or concurrent enrollment in Physics 11a or equivalent.

*Chemistry 91r. Introduction to Research
Catalog Number: 4366
James E. Davis and members of the Department
Half course (fall term; repeated spring term). Hours to be arranged.
Reading and/or laboratory work related to one of the research projects under way in the department.
Note: Open to a limited number of chemistry concentrators who are accepted as research students without having taken Chemistry 98. Written permission of the sponsor must be filed at the Office of the Head Tutor in Chemistry. Any student enrolling in this course must register the name of his or her research mentor with the course head, James E. Davis, and Dr. Davis’ signature must appear on each student’s study card.

*Chemistry 98r (formerly Chemistry 98hf). Introduction to Research—Junior Year
Catalog Number: 3124
James E. Davis and members of the Department
Half course (fall term; repeated spring term). Spring: Tu., Th., 1–2:30. EXAM GROUP: Spring: 15, 16
Research under the direction of, or approved by, a member of the faculty of the Department of Chemistry.
Note: Open with approval of the instructor to junior chemistry majors who have satisfactorily completed the non-credit Introduction to Research Tutorial in the spring term of the sophomore year. In that non-credit spring term tutorial, taught Tu., Th., 1–2:30, students will attend introductory lectures and research seminars in order to acquaint themselves with departmental research programs. In the junior year, students who complete the non-credit tutorial and obtain placement in a research laboratory will undertake research as Chemistry 98r. Written permission of the research adviser must be filed at the office of the Head Tutor in Chemistry. Any student enrolling in this course must register the name of his or her research mentor with the course head, James E. Davis, and Dr. Davis’ signature must appear on each student’s study card.

*Chemistry 99r (formerly Chemistry 99). Tutorial — Senior Year
Catalog Number: 4508
James E. Davis and members of the Department
Half course (fall term; repeated spring term). Hours to be arranged.
Research under the direction of, or approved by, a member of the faculty of the Department of Chemistry.
Note: Open to seniors accredited by the Department as honors candidates. Written permission of the research adviser must be filed at the office of the Head Tutor in Chemistry. Any student enrolling in this course must register the name of his or her research mentor with the course head, James E. Davis, and Dr. Davis’ signature must appear on each student’s study card.

Cross-listed Courses

Biological Sciences 52 (formerly Biological Sciences 10). Introductory Molecular Biology
[Earth and Planetary Sciences 107. Environmental Geochemistry]
[MCB 112. Structure and Function of Proteins and Nucleic Acids]
[MCB 176. Membrane Structure and Function]

For Undergraduates and Graduates

Chemistry 105. Mechanisms of Organic Reactions
Catalog Number: 3181
George M. Whitesides
Half course (spring term). M., W., F., at 10. EXAM GROUP: 3
The study of the relation between structure of carbon compounds and their reactivity and properties. Thermodynamics, electronic structure, reaction mechanisms, reactive intermediates, catalysis, structure-reactivity relations, influence of solvents on reactivity.
Prerequisite: Chemistry 5 and 7, or 10; and Chemistry 20 and 30 with a grade of B- or better. MCB 61 highly recommended.

Chemistry 115. Advanced Organic Chemistry: Synthesis of Complex Molecules
Catalog Number: 0480
Andrew G. Myers
Half course (fall term). Tu., Th., 10–11:30. EXAM GROUP: 12, 13
An integrated course in complex synthetic problem solving that focuses on the development of principles and strategies for synthesis design with a concurrent, comprehensive review of modern synthetic transformations.
Prerequisite: Chemistry 105 or a grade of A in Chemistry 30.

Chemistry 135. Experimental Synthetic Chemistry
Catalog Number: 3406 Enrollment: Limited to 64. Preference given to concentrators in Chemistry, Biochemical Sciences, and Biology, in that order.
Garry Procter
Half course (spring term). Lectures M., at 1, and laboratory, eight to nine hours a week, Tu., 2–10 p.m., W., 1–9 p.m., or Th., 2–10 p.m. EXAM GROUP: 6
An introduction to experimental problems encountered in the synthesis, isolation, purification, characterization, and identification of inorganic and organic compounds. Each student works on a different sequence of reactions chosen to encourage the development of technical proficiency and to simulate actual research.
Note: Recommended as an efficient preparation for research in experimental inorganic and organic chemistry and related sciences such as biochemistry and pharmacology. Normally follows Chemistry 27 or 30 and is strongly recommended as preparation for Chemistry 98 and 99.

Chemistry 150. Inorganic Chemistry II. The Transition Elements
Catalog Number: 6491
Richard H. Holm
Half course (fall term). Tu., Th., at 10, and a discussion section to be arranged. EXAM GROUP: 12
An introduction to the fundamental chemistry of the transition elements. Topics include synthesis, electronic structure, stereochemistry, substitution and electron-transfer reactions, organometallic chemistry, catalysis, and bioinorganic chemistry.
Prerequisite: Chemistry 40 or permission of the instructor.

[Chemistry 151. Advanced Inorganic Chemistry: A Physical Approach]
Catalog Number: 4343
Richard H. Holm
Half course (fall term). Hours to be arranged.
A physical approach to inorganic compounds, mainly of the transition elements including bonding, stereochemistry, and electronic properties with use of symmetry and elementary group theory.
Note: Expected to be given in 2001–02.

Chemistry 153. Organotransition Metal Chemistry
Catalog Number: 1848
Eric N. Jacobsen
Half course (spring term). Tu., Th., 10–11:30. EXAM GROUP: 12, 13
An introduction to organotransition metal chemistry. Topics include organometallic reaction mechanisms and the application of transition metal complexes in organic synthesis and in homogeneous catalysis.
Note: Intended primarily for graduate students and advanced undergraduates in chemistry.
Prerequisite: Chemistry 30 or equivalent, and Chemistry 40 or equivalent. Concurrent enrollment in Chemistry 115 and/or Chemistry 206 is recommended.

[Chemistry 154. Crystal Symmetry, Diffraction, and Structure Analysis]
Catalog Number: 8873
Richard J. Staples
Half course (spring term). ; laboratory one afternoon per week.
Theory of the internal symmetry and arrangement of atoms in crystals; development and use of space groups. Geometrical and physical aspects of the diffraction process, with emphasis on comprehensive interpretation of x-ray diffraction effects from single crystals. Methods of crystal structure analysis. Laboratory includes searching and utilizing the CSD database, as well as the data collection and crystal structure solution of a new single crystal.
Note: Expected to be given in 2001–02.
Prerequisite: Familiarity with atomic structure, basic symmetry principles, linear algebra, and electromagnetic waves.

[Chemistry 157. Biologically Related Inorganic Chemistry ]
Catalog Number: 6244
Richard H. Holm
Half course (spring term). Hours to be arranged.
The chemistry of metal ions and metal clusters in metallobiomolecules, with emphasis on structure, function, and reactivity; synthetic analogue chemistry related to native metal sites. The course may be conducted largely in a seminar format with extensive student participation.
Note: Expected to be given in 2001–02.
Prerequisite: Chemistry 150 or permission of the instructor.

Chemistry 158. Materials Chemistry
Catalog Number: 7504
Charles M. Lieber
Half course (fall term). Tu., Th., 1–2:30. EXAM GROUP: 15, 16
An introduction to inorganic and organic materials. Topics include: structure of crystalline solids; electronic structure and conduction in materials; crystal chemistry; synthesis of bulk, thin film, and nanoscale materials; structure-property relationships, including superconductivity, magnetism and giant magneto resistance, nonlinear optical materials, mesoporous structures, and monostructures.
Note: Primarily intended for advanced undergraduates and graduates.
Prerequisite: Chemistry 40 or equivalent.

Chemistry 160. Physical Chemistry
Catalog Number: 3420
Cynthia M. Friend
Half course (fall term). Tu., Th., 11:30–1. EXAM GROUP: 13, 14
An introduction to modern theories of the structure of matter, including the principles of quantum mechanics, the electronic structure of atoms and molecules, chemical bonding, and atomic and molecular spectra.
Prerequisite: Applied Mathematics 21a and 21b, Mathematics 21a and 21b, or equivalent preparation in calculus and differential equations; one full course in physics (with an honor grade, if in Physics 1); Chemistry 10 or equivalent.

Chemistry 161. Statistical Thermodynamics
Catalog Number: 3575
David R. Reichman
Half course (spring term). Tu., Th., 11:30–1. EXAM GROUP: 13, 14
An introduction to statistical mechanics, thermodynamics, and chemical kinetics with applications to problems in chemistry.
Prerequisite: Chemistry 160 and Applied Mathematics 21a, or equivalent.

Chemistry 162. Molecular Spectroscopy
Catalog Number: 0924
William Klemperer and Xiaoliang Sunney Xie
Half course (spring term). M., W., F., at 11. EXAM GROUP: 4
Modern molecular spectroscopy applied to the study of the structure and dynamics in gas and condensed phase systems. Topics include electronic, vibrational, rotational and nuclear hyperfine energy levels of polyatomic molecules, their interactions with electromagnetic radiation, selection rules and relaxation processes. The fundamental principles are illustrated by spectroscopic approaches, such as absorption, fluorescence, scattering magnetic resonance, as well as nonlinear processes and photochemistry.
Prerequisite: Chemistry 160 and 161; or Physics 143 and 181; (or equivalent preparation). Concurrent registration in Chemistry 161 or Physics 181 acceptable.

[Chemistry 164r. Molecular Biophysics and Biophysical Chemistry: Simulation of Macromolecules]
Catalog Number: 5588
----------
Half course (fall term). Hours to be arranged.
Introduction to the principles and methods used for the simulation of macromolecules of biological interest. Protein conformation and dynamics are emphasized. Empirical energy and molecular dynamics calculations as well as other approaches are described. Specific problems are discussed to illustrate the methodology. Examples include the cooperative mechanisms of hemoglobin, protein folding predictions, the nature of reaction rate enhancement in enzyme catalysis, motional properties of proteins, simulations of free energy changes in mutations, molecular recognition, and the properties of binding sites. The laboratory introduces students to molecular graphics and to simulation methodology. During reading period, each student carries out an original research project that makes use of these techniques.
Note: Expected to be given in 2001–02. It is suggested that students enroll in Biophysics 164 when this course is bracketed. Cannot be taken for credit by students who have completed Biophysics 164r.
Prerequisite: Biological Sciences 11 and one of the following: Chemistry 160, Biochemistry 61, Physics 143, or permission of instructor.

Chemistry 165. Experimental Physical Chemistry
Catalog Number: 0667
Bretislav Friedrich
Half course (spring term). Lectures: F., 1–2:30; laboratories M., or Tu., 1–5. EXAM GROUP: 6, 7
The course provides an introduction to the methods and techniques used in current physical chemistry research laboratories. Seven out of the total of ten laboratory assignments are experiments that are conducted directly in the Research Groups of the Chemistry Department. These involve: molecular beams; mass spectrometry; Fourier transform infrared and nuclear magnetic resonance spectroscopies; laser ablation; laser spectroscopy; scanning tunneling and atomic force microscopy; kinetics. Computer-based methods of data acquisition and analysis will be used throughout.
Note: Recommended as an efficient preparation for research in experimental physical chemistry/chemical physics and related sciences.
Prerequisite: Chemistry 160 or Physics 143a

[Chemistry 167. Surface and Interfacial Phenomena]
Catalog Number: 7480
Cynthia M. Friend
Half course (spring term). Hours to be arranged.
General principles governing surface and interfacial phenomena are developed using treatment of surface electronic and geometric structure as a foundation. The course will treat both theoretical and experimental tools for the investigation of surface structure. Selected spectroscopic techniques will also be treated, with emphasis on surface phenomena. The latter part of the course will develop principles of adsorption, reaction, and growth phenomena illustrated through current literature topics.
Note: Expected to be given in 2001–02. Primarily for graduates and advanced undergraduates in Chemistry, Physics, and Applied Sciences.
Prerequisite: Chemistry 160 or equivalent.

Chemistry 170. Chemical Biology
Catalog Number: 7754
David R. Liu
Half course (fall term). Tu., Th., 8:30–10. EXAM GROUP: 10, 11
This course explores many of the most interesting recent advances in applying chemical approaches to problems in chemistry and biology. Topics include: protein design and engineering, molecular evolution, DNA damage and repair, novel natural proteins, metabolic engineering, drug action and resistance, rational and combinatorial approaches to drug discovery, chemical genetics, and genomics. Lectures are supplemented with problem sets, discussion sections, and additional readings from the scientific literature.
Prerequisite: A strong background in organic chemistry, including basic biochemistry.

Cross-listed Courses

[Biophysics 164r (formerly Biophysics 151r). Molecular Biophysics and Biophysical Chemistry: Simulation of Macromolecules]

Primarily for Graduates

*Chemistry 206. Advanced Organic Chemistry
Catalog Number: 1063
David A. Evans
Half course (fall term). M., W., F., at 10. EXAM GROUP: 3
An in-depth discussion of the important classes of organic reactions will be provided. The discussion will include an introduction to FMO theory, streoelectronic effects, conformational analysis, and enantioselective reaction variants. Reaction families that will be surveyed include the major classes of cycloadditions, olefin and carbonyl addition processes, and sigmatropic rearrangements. The generation, structure, and reactivity of commonly encountered reactive intermediates such as enolates, metalloenamines, carbenes, carbonim ions, and free radicals will be integrated into the lectures. Weekly problem assignments designed to improve “electron-pushing” skills will be provided. Small study groups headed by experienced graduate student mentors will emphasize the development of problem-solving skills.
Prerequisite: Chemistry 105, a prior course in mechanistic organic chemistry, or permission of instructor.

Chemistry 240. Statistical Mechanics
Catalog Number: 5215
Eugene I. Shakhnovich
Half course (spring term). Tu., Th., 11:30–1. EXAM GROUP: 13, 14
Equilibrium and nonequilibrium statistical mechanics, with a strong emphasis on interacting systems, including the thermodynamics and structure of gases, liquids, and crystals, critical phenomena, and the theory of transport processes.
Prerequisite: Chemistry 160 and 161, or permission of instructor.

[Chemistry 241. Chemical Kinetics]
Catalog Number: 6976
Dudley R. Herschbach
Half course (spring term). Hours to be arranged.
Theory of bimolecular gas phase reactions, success of those theories when applied to reactions of free radicals, unimolecular and thermomolecular rate theories, thermochemistry, energy transfer and recent advances in molecular beam and laser chemistry.
Note: Expected to be given in 2001–02. Given in alternate years.

Chemistry 242. Quantum Mechanics
Catalog Number: 2971
William Klemperer and Hongkun Park
Half course (fall term). M., W., F., at 12. EXAM GROUP: 5
Principles of quantum mechanics. Particle in potential. Identical particles. Angular momemtum. Perturbation theory. Electron motion in atoms, molecules and solids. Born-Oppenheimer theory.
Prerequisite: Chemistry 160 or Physics 143, Physics 11 or 12, and Applied Mathematics 105a and 105b, or Mathematics 21, or equivalent.

[Chemistry 243. Time-Dependent Quantum Mechanics]
Catalog Number: 0566
Eric J. Heller
Half course (spring term). Hours to be arranged.
Treatment of time-dependent interactions, for bound, quasi-stationary, and scattering states. Applications to molecular spectroscopy and collision processes.
Note: Expected to be given in 2001–02. Given in alternate years.
Prerequisite: Chemistry 242.

Chemistry 244. Quantum Chemistry
Catalog Number: 8295
Roy G. Gordon
Half course (fall term). W., 12–2. EXAM GROUP: 5, 6
Quantum mechanics applied to molecules and solids. Hartree-Fock, configuration-interaction, perturbation, coupled cluster, density functional, Monte-Carlo and semi-empirical theories. Use of computer programs for these methods.
Prerequisite: Chemistry 242.

Chemistry 245. Single-molecule Biophysics
Catalog Number: 0944
Xiaoliang Sunney Xie
Half course (fall term). W., F., at 11. EXAM GROUP: 4
The emerging single-molecule methodology of biophysics, including the principles of single-molecule studies and the experimental approaches, such as the patch clamp technique, atomic force microscopy, optical tweezers, near field microscopy, and confocal and nonlinear optical microscopy. Applications to various biological problems will be discussed.
Prerequisite: Introductory level biochemistry and physical chemistry including quantum mechanics and statistical mechanics; or permission of instructor.

[Chemistry 248. Special Topics in Physical Chemistry]
Catalog Number: 0587
William Klemperer
Half course (spring term). Hours to be arranged.
Topics of current interest, to be announced.
Note: Expected to be given in 2001–02.
Prerequisite: Chemistry 160 and 161 or equivalent.

Cross-listed Courses

Earth and Planetary Sciences 200. Atmospheric Chemistry and Physics
Earth and Planetary Sciences 202. Introduction to the Dynamics of Atmospheres and Oceans
[Engineering Sciences 264. Chemistry of Natural and Polluted Waters]

Graduate Courses of Reading and Research

A student intending to elect one of the following research courses should consult the instructor as far in advance as possible.
*Chemistry 300. Reading
Catalog Number: 6307
Members of the Department
Individual work under the supervision of members of the Department.

*Chemistry 301. Inorganic Chemistry
Catalog Number: 3748
Richard H. Holm 7015

*Chemistry 302. Organometallic Chemistry
Catalog Number: 1413
Eric N. Jacobsen 1040

*Chemistry 303. Organic Chemistry
Catalog Number: 1043
David A. Evans 7774

*Chemistry 307. Organic Chemistry
Catalog Number: 5101
Elias J. Corey 1369

*Chemistry 311. Physical Chemistry
Catalog Number: 2640
Charles M. Lieber 3102

*Chemistry 313. Organic Chemistry
Catalog Number: 0183
Yoshito Kishi 3852

*Chemistry 315. Photochemistry and Kinetics
Catalog Number: 5964
James G. Anderson 6057 (on leave fall term)

*Chemistry 318. Organic Chemistry
Catalog Number: 4295
George M. Whitesides 7447

*Chemistry 323. Organic Chemistry
Catalog Number: 2477
Stuart L. Schreiber 2166

*Chemistry 325. Physical Chemistry
Catalog Number: 8530
Cynthia M. Friend 7446 (on leave spring term)

*Chemistry 327. Theoretical Chemistry
Catalog Number: 6064
Martin Karplus 1361

*Chemistry 330. Physical Chemistry and Chemical Physics
Catalog Number: 4327
Dudley R. Herschbach 1381 (on leave spring term)

*Chemistry 331. Chemical Biology
Catalog Number: 1408
Gregory L. Verdine 1980

*Chemistry 336. Physical and Inorganic Chemistry and Materials Science
Catalog Number: 5266
Roy G. Gordon 1353

*Chemistry 350. Theoretical Physical Chemistry
Catalog Number: 8285
Eugene I. Shakhnovich 3147

*Chemistry 377. Physical Chemistry, Including Molecular Spectroscopy
Catalog Number: 5506
William Klemperer 1391

*Chemistry 387. Organic Chemistry
Catalog Number: 4674
Matthew D. Shair 2280

*Chemistry 388. Organic Chemistry
Catalog Number: 1979
Andrew G. Myers 8278

*Chemistry 389. Physical Chemistry
Catalog Number: 5111
Xiaoliang Sunney Xie 2290

*Chemistry 390. Organic Chemistry and Chemical Biology
Catalog Number: 7469
David R. Liu 2717

*Chemistry 391. Physical Chemistry
Catalog Number: 9897
Hongkun Park 2485

*Chemistry 392. Physical Chemistry
Catalog Number: 6980
David R. Reichman 2569