Biological Sciences in Public Health

Faculty of the Committee on Higher Degrees in Public Health

Dyann F. Wirth, Professor of Immunology and Infectious Diseases (Public Health) (Chair)
Joseph D. Brain, Cecil K. and Phillip Drinker Professor of Environmental Physiology (Public Health)
John R. David, Professor of Medicine (Medical School) and Richard Pearson Strong Professor of Tropical Public Health (Public Health)
Raymond L. Erikson, American Cancer Society Professor of Cellular and Developmental Biology
Myron E. Essex, Mary Woodard Lasker Professor of Health Sciences (Public Health)
Thomas O. Fox, Associate Professor of Neuroscience (Medical School)
J. Woodland Hastings, Paul C. Mangelsdorf Professor of Natural Sciences (on leave spring term)
John B. Little, James Stevens Simmons Professor of Radiobiology (Public Health)
Bjørn R. Olsen, Hersey Professor of Cell Biology and Professor of Oral Biology (Medical School)
Armen H. Tashjian, Jr., Professor of Toxicology in the Faculty of Public Health, emeritus (Public Health) and Professor of Biological Chemsitry and Molecular Pharmacology (Medical School)
Walter C. Willett, Professor of Medicine (Medical School) and Frederick John Stare Professor of Epidemiology and Nutrition (Public Health)

Other Faculty Offering Instruction in Biological Sciences in Public Health

Robert B. Banzett, Associate Professor of Medicine and Associate Professor in the Department of Environmental Health (Medical School, Public Health)
Barry R. Bloom, Dean of the Faculty and Professor of Immunology & Infectious Diseases (Public Health)
Harriet A. Burge, Associate Professor of Environmental Microbiology (Public Health)
Barbara Burleigh, Assistant Professor of Immunology & Infectious Diseases (Public Health)
Hannia Campos, Assistant Professor of Nutrition (Public Health)
David Christiani, Professor of Medicine (Medical School)
Bruce F. Demple, Professor of Toxicology (Public Health)
Claire M. Doerschuk, Mark and Catherine Winkler Associate Professor of Physiology and Cell Biology (Public Health) and Associate Professor of Pathology (Medical School)
Timothy E. Ford, Assistant Professor of Environmental Microbiology (Public Health)
Jeffrey J. Fredberg, Professor of Bioengineering and Physiology (Public Health)
Laurie H. Glimcher, Professor of Medicine (Medical School) and Irene Heinz Given Professor of Immunology (Public Health)
Michael Grusby, Associate Professor of Molecular Immunology and Assistant Professor of Medicine (Public Health)
Donald A. Harn, Professor of Tropical Public Health (Public Health)
I-Cheng Ho, Assistant Professor of Immunology & Infectious Diseases (Public Health)
Phyllis J. Kanki, Associate Professor of Pathobiology (Public Health)
Karl Kelsey, Associate Professor of Occupational Medicine (Public Health) and Associate Professor of Medicine (Medical School)
Lester Kobzik, Associate Professor of Pathology Medical School and Associate Professor in the Department of Environmental Health (Public Health)
Igor Kramnik, Assistant Professor of Immunology (Public Health)
Arthur M.-E. Lee, Associate Professor of Molecular Biology (Public Health) and Associate Professor of Medicine (Medical School)
Catherine A. Lee, Silas Arnold Houghton Associate Professor of Microbiology and Molecular Genetics (Medical School)
Tun-Hou Lee, Associate Professor of Virology (Medical School)
Jeffrey Leiden, Professor of Molecular Pathology in Cardiovascular Diseases (Public Health) and Professor of Medicine (Medical School)
Carl G. Maki, Assistant Professor of Radiobiology (Public Health)
Karl Münger, Associate Professor of Pathology (Medical School)
Joseph D. Paulauskis, Associate Professor of Molecular Biology (Public Health)
Mark Perrella, Assistant Professor of Medicine (Medical School) and Assistant Professor in the Division of Biological Sciences (Public Health)
Willy F. Piessens, Professor of Tropical Public Health (Public Health) and Associate Professor of Medicine (Medical School)
Guy L. Reed III, Assistant Professor of Medicine (Medical School) and Assistant Professor of Immunology(Public Health)
Frank M. Sacks, Associate Professor of Medicine (Medical School) and Associate Professor in the Department of Nutrition (Public Health) (Medical School, Public Health)
Leona D. Samson, Professor of Toxicology (Public Health)
John C. Samuelson, Associate Professor of Tropical Public Health (Public Health) and Clinical Fellow in Pathology (Medical School)
Robert H. Schiestl, Associate Professor of Toxicology (Public Health)
Steven A. Shea, Assistant Professor in the Department of Environmental Health (Public Health) and Assistant Professor of Medicine (Medical School)
Stephanie A. Shore, Associate Professor of Physiology (Public Health)
Joseph G. Sodroski, Professor of Pathology Medical School and Professor of Cancer Biology (Public Health)
Ning Wang, Assistant Professor of Physiology and Cell Biology (Public Health)
Marianne Wessling-Resnick, Associate Professor of Nutrition (Public Health)
Dieter Wolf, Assistant Professor of Toxicology (Public Health)
Xiping Xu, Associate Professor of Occupational Epidemiology (Public Health) and Associate Professor of Medicine (Medical School)
Zhi-Min Yuan, Assistant Professor of Radiobiology (Public Health)

See other courses in the School of Public Health catalog.

Primarily for Graduates

BPH 201. Statistical Methods in Biology
Catalog Number: 7335 Enrollment: Limited to 20.
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Half course (spring term). M., 3:30–5:20, Th., 10:30–12:20, plus laboratory to be arranged.
Designed to familiarize students with the statistical methods used in laboratory research for design of experiments and statistical analysis of hypotheses. Topics include basic theory of probability and statistics, analysis of continuous and categorical data, ANOVA and multiple regression and nonparametric methods. Examples focus on statistical problems encountered in laboratory research.
Note: Offered jointly with the Medical School as BPH 725.0, and with the School of Public Health as DBB 207cd.

BPH 206. Advanced Respiratory Physiology
Catalog Number: 1049
James N. Butler
Half course (fall term). M., W., 9–10:20.
Covers a broad range of topics in respiratory physiology including: lung structure, volume and flow mechanics, surfactant function, gas exchange, lung and chest wall interaction. Special topics may include pulmonary circulation, lung endocrine functions, airway physiology and pharmacology. Reviews classic concepts and presents some recent advances.
Note: Offered jointly with the School of Public Health as EH 223ab. Offered jointly with the Medical School as BPH 735.0.
Prerequisite: College-level physiology and EH 205ab or equivalent or signature of instructor indicating suitable background required.

BPH 207. Advanced Topics in Physiology
Catalog Number: 2146
Jeffrey J. Fredberg (Public Health) and Joseph D. Paulauskis (Public Health)
Half course (spring term). M., 10:30–12:20, W., 3:30–5:20.
Focus on special topics in lung biology. Emphasis is on the fundamental physical basis and quantitative description of chemical, electrical, and mechanical signaling within the cell. Specific topics include passive diffusion, facilitated diffusion, solvent and solvent transport, channels, action potentials, membrane transport, and receptor ligand binding.
Note: Offered jointly with the Medical School as BPH 727.0, and with the School of Public Health as EH 225cd.

BPH 208. Human Physiology
Catalog Number: 3627
Robert B. Banzett (Medical School, Public Health) and members of the Department
Half course (fall term). M., W., 10:30–12:20.
An intensive introduction to the function of the human organism. Emphasis is placed on the concept of homeostasis and on integrative aspects of physiology. Examples of pathophysiology will be used to emphasize certain concepts. This course is mainly a lecture-based introductory course intended for students who have not had college-level physiology. Course activities: Problem sets, exams, periodic required laboratories.
Note: To encourage students with no biology background to take the course, we provide ten hours of extra lectures in basic biological concepts concurrent with the first two weeks of class. Offered jointly with the Medical School as BPH 728.0 and with the School of Public Health as EH 205ab.
Prerequisite: College level introductory biology or permission of the instructor is required.

BPH 210. Pathophysiology of Human Disease
Catalog Number: 3078
Lester Kobzik (Public Health)
Half course (spring term). M., F., 1:30–3:20.
Surveys common and important human disease problems in the major organ systems. Emphasis on understanding the pathophysiologic basis of typical disease manifestations and the pathogenesis of the disease process at a cellular and molecular level. Relevant public health perspectives on the epidemiology or control of disease are also integrated.
Note: Offered jointly with the Medical School as BPH 729.0, and with the School of Public Health as DBE 208cd.
Prerequisite: College-level physiology, EH 205ab, or equivalent.

[BPH 211. Survey of Immunobiology]
Catalog Number: 5053 Enrollment: Limited to 22.
Michael Grusby (Public Health)
Half course (fall term). Hours to be arranged.
Exmaines the anatomy and physiology of the immune system, fate of antigen, cell trafficking, cellular interactions, regulation of the immune response, and B- and T-cell recognition mechanisms.
Note: Expected to be given in 2000–01. Given in alternate years. Offered jointly with the School of Public Health as CB 204ab (five credits).

[BPH 213. Molecular and Cellular Toxicology: Seminar]
Catalog Number: 0932 Enrollment: Limited to 15
Bruce F. Demple (Public Health)
Half course (spring term). M., W., 1:30–3:20.
Examines key issues and approaches in modern toxicology, focused on emerging research at the molecular and cellular levels. Specific topics include genetic toxicology (DNA repair, aberrant recombination, genetic instability, effect of carcinogens on gene expression, etc.), pathology of the cell cycle, carcinogenesis (tumor promotion, molecular biology of tumor suppressors), molecular epidemiology, and risk analysis. This course focuses intensively on critical analysis of research papers.
Note: Expected to be given in 2000–01. Given in alternate years. Offered jointly with the Medical School as BPH 723.0 and the School of Public Health as CCB 250cd. Contact instructor at 432-3462.
Prerequisite: Courses in biochemistry, cell biology, and genetics.

BPH 215 (formerly BCMP 218). Principles of Toxicology
Catalog Number: 5366
Robert H. Schiestl (Public Health)
Half course (fall term). Tu., Th., 1:30–3:20.
Introductory course emphasizing mechanisms of injury and clinical consequences following exposures to environmental and occupational chemicals. Actions are examined at the molecular, cellular, organ, and organismal levels. Methods for detection and evaluating toxic effects of environmental and industrial chemicals are discussed.
Note: Offered jointly with the Medical School as BPH 713.0 and with the School of Public Health as CCB 204ab.
Prerequisite: Biochemistry and Physiology courses are recommended; may be taken concurrently.

[BPH 216. Immunology of Infectious Diseases]
Catalog Number: 6938
Donald A. Harn (Public Health)
Half course (spring term). Tu., 3:30–5:20.
Presents the interactions of pathogens with the host immune system, from pathogen invasion to pathogenesis.
Note: Expected to be given in 2000–01. Given in alternate years. Offered jointly with the School of Public Health as IMI 208cd (five credits).

*BPH 219. Biological Sciences Seminars
Catalog Number: 1152
Michael Grusby (Public Health) and I-Cheng Ho (Public Health)
Half course (fall term). Tu., Th., 8:30–10:30 a.m.
Faculty participating in the Biology and Public Health degree program present seminars on their current research in the biological sciences and direct a student discussion of the logic and experimental design of this research. Topics include chemical and viral carcinogenesis, DNA damage and repair, immunology, molecular biology, metabolism, cardiovascular disease, parisitology, and how these areas apply to public health issues. Students also participate in critical reading of “great papers in science” and are required to present this work to the class for discussion.
Note: Required for first-year students in the BPH program, with permission of the instructor. Offered jointly with the School of Public Health as DBS 205ab, and with the Medical School as BPH 736.0.

[BPH 220. Introduction to Cancer Biology: Radiation Biology, Gene Regulation and Therapy]
Catalog Number: 1208
John B. Little (Public Health)
Half course (fall term). M., F., 1:30–3:20.
Provides an understanding of the genotoxic and carcinogenic effects of ionizing radiation. Topics include the induction and repair of DNA damage; the processes of cell killing, mutagenesis and cell transformation; effects on chromosomes, cell cycle and proliferation; radiation carcinogenesis; leukemogenesis and aging; mammalian radiation genetics; effects on the developing embryo and fetus.
Note: Expected to be given in 2000–01. Given in alternate years. Offered jointly with the Medical School as BPH 732.0, and with the School of Public Health as CCB 207ab.
Prerequisite: College-level course in biology.

BPH 222. The Science of Human Nutrition
Catalog Number: 0216
Frank M. Sacks (Medical School, Public Health), Clifford Lo (Medical School) and members of the Faculty
Half course (spring term). Tu., Th., 1:30–3:20.
Reviews the biochemistry of carbohydrates, fats, proteins, vitamins, and minerals in the context of human disease. Particular emphasis given to current knowledge of the mechanisms that may explain the role of diet in the causation and/or prevention of ischemic heart disease, diabetes, obesity, hypertension, and cancer. Recommended dietary intakes of selected nutrients are discussed in order to understand their limitations.
Note: NUT 201ab is strongly recommended; prior familiarity with nutrition and the health sciences is expected, as is a basic knowledge of biochemistry and human physiology. Offered jointly with the Medical School as BPH 733.0, and with the School of Public Health as NUT 202cd.

Graduate Courses of Reading and Research

*BPH 300r. Laboratory Rotations
Catalog Number: 8441
Dyann F. Wirth (Public Health) 2492
Half course (fall term; repeated spring term). Hours to be arranged.
Members of the Division of Biological Sciences offer hands-on experimental methods of research in the biological sciences.
Note: Offered jointly with the School of Public Health as DBS 300ab, DBS 300cd.

*BPH 302. Molecular Regulation of Thrombosis
Catalog Number: 2731
Guy L. Reed III (Public Health, Medical School) 1615

*BPH 303. Transcriptional Regulation of Endothelial and Smooth Muscle Cell-Specific Genes
Catalog Number: 2760
Arthur M.-E. Lee (Public Health, Medical School) 1620

*BPH 304. Study of Workplace Mutagen and Carcinogen Exposure
Catalog Number: 2734
Karl Kelsey (Public Health, Medical School) 2316

*BPH 305. Molecular Mechanisms of Pulmonary Inflammation
Catalog Number: 2676
Joseph D. Paulauskis (Public Health) 1305

*BPH 306. Circadian and Sleep Physiology and Disorders
Catalog Number: 2730
Steven A. Shea (Public Health, Medical School) 1309

*BPH 307. Cellular Defenses Against Oxygen Radical Damage
Catalog Number: 2758
Bruce F. Demple (Public Health) 7853

*BPH 308. Genetic and Environmental Effects on Homologous and Illegitimate Recombination in Yeast, Human Cells, and Mice
Catalog Number: 2735
Robert H. Schiestl (Public Health) 3391

*BPH 310. The Response of Bacterial, Yeast, and Mammalian Cells to DNA Damage
Catalog Number: 2726
Leona D. Samson (Public Health) 1068

*BPH 311. Molecular Mechanisms of Control of the Biosynthesis, Secretion, and Action of Polypeptide Hormones
Catalog Number: 2757
Armen H. Tashjian, Jr. (Public Health, Medical School) 2071

*BPH 312. Regulation of the Cellular Uptake of Macromolecular Nutrients
Catalog Number: 2736
Marianne Wessling-Resnick (Public Health) 1315

*BPH 313. Mechanisms of Drug Resistance in Entamoeba histolytica
Catalog Number: 2681
John C. Samuelson (Public Health, Medical School) 1618

*BPH 315. Molecular Genetic Analysis of Gene Expression and Drug Resistance in Parasitic Protozoan, Including Leishmania and Malaria
Catalog Number: 2756
Dyann F. Wirth (Public Health) 2492

*BPH 316. Immunology and Molecular Biology of Schistosoma mansoni
Catalog Number: 2737
Donald A. Harn (Public Health) 2051

*BPH 317. Gene-Environment Interactions in Human Lipoprotein Metabolism
Catalog Number: 2541
Hannia Campos (Public Health) 2710

*BPH 318. Mechanisms Underlying the Response of Leukocytes During Inflammatory Lung Disease
Catalog Number: 7047
Claire M. Doerschuk (Public Health, Medical School) 2711

*BPH 319. Signaling Mechanisms of Peptide Hormones, Genetic and Molecular Basis of Obesity and Diabetes
Catalog Number: 8425
Gokhan S. Hotamisligil (Public Health) 2725

*BPH 321. Mechanical Mechanisms of Cytoskeleton and its Regulatory Role in Cell Growth and Migration
Catalog Number: 5552
Ning Wang (Public Health) 2737

*BPH 322. Study of Epidemiologic and Biological Characteristics of HIV Viruses in Africa
Catalog Number: 4523
Phyllis J. Kanki (Public Health) 2270

*BPH 323. Human Lipoprotein Metabolism: Biochemistry and Metabolic Modeling
Catalog Number: 5530
Frank M. Sacks (Medical School, Public Health) 2276

*BPH 324. Protein Phosphorylation and Gene Expression in Normal and Transformed Cells
Catalog Number: 5915
Raymond L. Erikson 7506

*BPH 325. Assessment of the Impact of Workplace Pollutants on Health
Catalog Number: 7448
David Christiani (Public Health, Medical School) 1514

*BPH 330. Advanced Topics in Biological Sciences in Public Health
Catalog Number: 3976
Marianne Wessling-Resnick (Public Health) 1315
A series of discussion and seminars each running for a half semester (7-8 weeks). Two seminars, which can be taken in different semesters, are required for half course credit.

*BPH 331. Perception of Afferent Information from the Respiratory System
Catalog Number: 3655
Robert B. Banzett (Medical School, Public Health) 1310

*BPH 332. Function and Structure of Pulmonary and Hepatic Macrophages
Catalog Number: 7331
Joseph D. Brain (Public Health) 2520

*BPH 333. Nature, Prevalence, Health Effects, and Control of Airborne Biological Agents
Catalog Number: 1556
Harriet A. Burge (Public Health) 2761

*BPH 334. Molecular Basis of Host Cell Invasion, Signaling and Differentiation by the Human Pathogen, Trypanosoma cruzi
Catalog Number: 2409
Barbara Burleigh (Public Health) 2763

*BPH 335. The Biology of Cytokines and the Control of Parasitic Infections
Catalog Number: 9204
John R. David (Public Health, Medical School) 3592

*BPH 336. Study of Human and Primate T-lymphotrophic Retroviruses Including Agents that Cause AIDS
Catalog Number: 3248
Myron E. Essex (Public Health) 2499

*BPH 337. Environmental Pollution, Waterborne Disease, Pathogen Survival
Catalog Number: 5110
Timothy E. Ford (Public Health) 1525

*BPH 338. Sexual Differentiation of the Brain: Hormonal and Genetic Determinants
Catalog Number: 4954
Thomas O. Fox (Medical School) 4542

*BPH 339. Mechanical Basis of Airway and Lung Parenchymal Function
Catalog Number: 6572
Jeffrey J. Fredberg (Public Health) 1303

*BPH 340. Genetic Regulation of Immune Response
Catalog Number: 3323
Laurie H. Glimcher (Public Health, Medical School) 1362

*BPH 341. Pathways of Oxidant-dependent Promotion of Cell Growth in Lung Epithelial Cells
Catalog Number: 9308
Beatriz Susana Gonzalez Flecha (Medical School) 2715

*BPH 342. In Vivo Models of Immune Deficiency by Homologous Recombination in ES Cells
Catalog Number: 2309
Michael Grusby (Public Health, Medical School) 1987

*BPH 343. Molecular Mechanism of Cellular Circadian Regulation
Catalog Number: 7740
J. Woodland Hastings 1311 (on leave spring term)

*BPH 344. Differentiation and Activation of Helper T Cells
Catalog Number: 2319
I-Cheng Ho (Public Health) 2764

*BPH 345. Lung Macrophage Differentiation and Function
Catalog Number: 1495
Lester Kobzik (Medical School, Public Health) 1313

*BPH 346. Genetic Dissection of Mechanisms of Host Susceptibility to Tuberculosis
Catalog Number: 1041
Igor Kramnik (Public Health) 2768

*BPH 347. Bacterial Pathogenesis, Virulence Gene Regulation, Salmonella Invasion
Catalog Number: 0567
Catherine A. Lee (Medical School) 3259

*BPH 348. Human and Related Primate Retroviruses
Catalog Number: 3024
Tun-Hou Lee (Medical School) 2769

*BPH 349. Transcriptional Regulation of Cardiovascular Development
Catalog Number: 4817
Jeffrey Leiden (Public Health, Medical School) 2771

*BPH 350. Radiation Mutagenesis and Cardinogenesis; Genetic Instability
Catalog Number: 9227
John B. Little (Public Health) 1427

*BPH 351. Stability and Ubiquitination of Cell Cycle Regulatory Proteins
Catalog Number: 4657
Carl G. Maki (Public Health) 2773

*BPH 352. Regulation of Acute Inflammatory Responses by Signaling Molecules
Catalog Number: 5578
Joseph P. Mizgerd (Medical School) 2787

*BPH 353. Human Papillomaviruses (HPV’s): the Cause of Hyperplastic Skin-leisions
Catalog Number: 6469
Karl Münger (Medical School) 1586

*BPH 354. Molecular Studies of Skeletal and Vascular Morphogenesis
Catalog Number: 8067
Bjørn R. Olsen (Medical School) 1164

*BPH 355. Cytokine Regulation of Vasoactive Mediators in the Pathogenesis of Septic Shock
Catalog Number: 9398
Mark Perrella (Public Health, Medical School) 2774

*BPH 356. Immunology and Molecular Biology of Filarial Nematodes
Catalog Number: 1435
Willy F. Piessens (Public Health, Medical School) 2779

*BPH 357. Physiological and Pharmacological Aspects of Bronchoconstriction.
Catalog Number: 5047
Stephanie A. Shore (Public Health) 1304

*BPH 358. Human Immunodeficiency Virus Envelope Glycoproteins and Vaccine Development
Catalog Number: 0241
Joseph G. Sodroski (Medical School, Public Health) 1712

*BPH 359. Relations of Dietary Factors to the Occurrence of Human Disease
Catalog Number: 8215
Walter C. Willett (Public Health, Medical School) 1805

*BPH 360. DNA Replication and Control of Normal and Abnormal Cell Growth
Catalog Number: 1395
Dieter Wolf (Public Health) 2781

*BPH 361. Genetic Dissection of Complex Diseases
Catalog Number: 1537
Xiping Xu (Public Health, Medical School) 2785

*BPH 362. Delineation of Biochemical and Molecular Basis of Stress Induced Responses
Catalog Number: 4140
Zhi-Min Yuan (Public Health) 9265